G protein-coupled receptor signalling in in vivo cardiac overload

Acta Physiologica Scandinavica

Volumn 173, Issue 1, 2001, Pages 51-57

  Rapacciuolo, A ^a   Esposito, G ^a   Naga Prasad, S V ^a   Rockman, H A ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Catecholamines; G protein coupled receptors; Heart failure; Hypertrophy; Phosphoinositide 3 kinase

Indexed keywords

CATECHOLAMINE; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

CATECHOLAMINE BLOOD LEVEL; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HUMAN; IN VIVO STUDY; MECHANICAL STRESS; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOMEGALY; GTP-BINDING PROTEINS; HEART FAILURE, CONGESTIVE; SIGNAL TRANSDUCTION;

EID: 0034786780     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2001.00884.x     Document Type: Review

References (42)

1. Targeting the receptor-G(q) interface to inhibit in vivo pressure overload myocardial hypertrophy
2. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts
3. Enhanced contractility and decreased β-adrenergic receptor kinase 1 in mice lacking endogenous norepinephrine and epinephrine
4. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase
5. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases
6. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts
7. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
8. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
9. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
10. Transgenic Galphaq overexpression induces cardiac contractile failure in mice
11. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload
12. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)
13. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
14. Phosphatidyl-inositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
15. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy
16. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor
17. Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats
18. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation
19. G-protein-coupled receptor kinases
20. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
21. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation
22. Adrenergic effects on the biology of the adult mammalian cardiocyte
23. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
24. Gβγ dependent phosphoinositide-3-kinase activation in hearts with in vivo pressure overload hypertrophy
25. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by {b}-adrenergic receptor kinase 1: A role in receptor sequestration
26. The role of phosphoinositide 3-kinase lipid products in cell function
27. Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure overload cardiac hypertrophy
28. Mitogen-activated protein kinase pathways
29. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy
30. Expression of a β-adrenergic receptor kinase1 inhibitor prevents the development of heart failure in gene-targeted mice
31. Control of myocardial contractile function by the level of β-adrenergic receptor kinase1 in gene-targeted mice
32. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT 1 receptor subtype
33. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response
34. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
35. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
36. Intracellular signalling through protein kinases in the heart
37. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline
38. Noradrenaline is essential for mouse fetal development
39. Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase
40. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart
41. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart
42. Phosphoinositide 3-kinases: A conserved family of signal transducers