Transplantable hematopoietic stem cells in human fetal liver have a CD34+ side population (SP) phenotype

Journal of Clinical Investigation

Volumn 108, Issue 7, 2001, Pages 1071-1077

  Uchida, Naoyuki ^a   Fujisaki, Tomoaki ^a   Eaves, Allen C ^a   Eaves, Connie J ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ADOLESCENT; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL ISOLATION; CELL SUBPOPULATION; FETUS; FETUS LIVER; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONTOGENY; PHENOTYPE; PRIORITY JOURNAL; SCID MOUSE;

EID: 0034784510     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13297     Document Type: Article

References (48)

1. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
2. Dystrophin expression in the mdx mouse restored by stem cell transplantation
3. Bone marrow cells regenerate infarcted myocardium
4. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells
5. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
6. +enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice
7. + peripheral blood stem cells in patients with advanced hematologic malignancy
8. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation
9. + hematopoietic stem cells in patients with metastratic breast cancer
10. + hematopoietic stem cells (HSCs) in multiple myeloma: Impact of HSC dose on engraftment, safety, and immune reconstitution
11. - progenitor cells
12. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers
13. A newly discovered class of human hematopoietic cells with SCID-repopulating activity
14. + cells
15. - cells stimulated by multiple growth factors in vitro
16. +Lin hematopoietic stem cells using cell surface markers AC133 and CD7
17. + hematopoietic cells
18. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
19. Developmental changes of CD34 expression by murine hematopoietic stem cells
20. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
21. Reversible expression of CD34 by murine hematopoietic stem cells
22. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
23. Reversal mechanism of multidrug resistance by verapamil: Direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells
24. Mouse hematopoietic stem cells
25. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
26. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
27. + lymphoid progenitor in human unbilical cord blood
28. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
29. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
30. Expression of CD34 on human B cell precursors
31. Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulating factor
32. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
33. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
34. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haematopoietic cells in NOD/SCID mice transplanted with human cord blood
35. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow
36. Unique differentiation programs of human fetal liver stem cells revealed both in vitro and in vivo in NOD/SCID mice
37. Hematopoietic potential of stem cells isolated from murine skeletal muscle
38. Expression of the breast cancer resistance protein (BCRP) in side population (SP) stem cells, natural killer (NK) lymphocytes, and erythroid progenitor cells
39. The transporter ABCG2 effluxes hoechst and its expression is restricted to the most primitive human hematopoietic cells
40. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
41. A multidrug resistance transporter from human MCF-7 breast cancer cells
42. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
43. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines
44. The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane
45. Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population
46. Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
47. -) hematopoietic cells show altered expression of a subset of genes associated with early cytokine and differentiation responses of their adult counterparts
48. The total marrow mass of the mouse: A simplified method of measurement