Rapid differentiation of a rare subset of adult human lin-CD34-CD38- cells stimulated by multiple growth factors in vitro

Blood

Volumn 94, Issue 6, 1999, Pages 1926-1932

  Fujisaki, Tomoaki ^b   Berger, Marc G ^b   Rose John, Stefan ^b   Eaves, Connie J ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; FLT3 LIGAND; GROWTH FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; STEEL FACTOR; THROMBOPOIETIN;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING CELL; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL;

EID: 0033568577     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.6.1926     Document Type: Article

References (31)

1. Eaves CJ: Myelopoiesis, in Henderson ES, Lister TA, Greaves MF (eds): Leukemia. Philadelphia, PA, Saunders, 1996, p 46
2. Krause DS, Fackler MJ, Civin CI, May WS: CD34: Structure, biology, and clinical utility. Blood 87:1, 1996
3. -SCID neonates. Nat Med 4:775, 1998
4. -SCID. Blood 84:3584, 1994
5. Conneally E, Cashman J, Petzer A, Eaves C: Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA 94:9836, 1997
6. Larochelle A, Vormoor J, Hanenberg H, Wang JCY, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE: Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nat Med 2:1329, 1996
7. + human marrow cells that express low levels of kit protein are enriched for long-term marrow-engrafting cells. Blood 87:4136, 1996
8. Osawa M, Hanada KI, Hamada H, Nakauchi H: Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242, 1996
9. + bone marrow cells. Exp Hematol 26:440, 1998
10. Jones RJ, Collector MI, Barber JP, Vala MS, Fackler MJ, May WS, Griffin CA, Hawkins AL, Zehnbauer BA, Hilton J, Colvin OM, Sharkis SJ: Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity. Blood 88:487, 1996
11. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP: Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3:1337, 1997
12. + cells. Exp Hematol 26:353, 1998
13. Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick J: A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 4:1038, 1998
14. -) human hematopoietic cells: Novel responses to flt3-ligand and thrombopoietin. J Exp Med 183:2551, 1996
15. Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ: Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci USA 94:4698, 1997
16. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
17. - bone marrow cells with multilineage potential at the single-cell level: Key role of thrombopoietin. Blood 90:2282, 1997
18. Zandstra PW, Conneally E, Piret JM, Eaves CJ: Ontogeny-associated changes in the cytokine responses of primitive human haematopoietic cells. Br J Haematol 101:770, 1998
19. + cells. J Exp Med 184:1357, 1996
20. Fischer M, Goldschmitt J, Peschel C, Brakenhoff JPG, Kallen KJ, Wollmer A, Grötzinger J, Rose-John S: A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 15:142, 1997
21. Hogge D, Fanning S, Bockhold K, Petzer A, Lambie K, Lansdorp P, Eaves A, Eaves C: Quantitation and characterization of human megakaryocyte colony-forming cells using a standardized serum-free agarose assay. Br J Haematol 96:790, 1997
22. Hogge DE, Lansdorp PM, Reid D, Gerhard B, Eaves CJ: Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulating factor. Blood 88:3765, 1996
23. Taswell C: Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J Immunol 126: 1614, 1981
24. Petzer AL, Hogge DE, Lansdorp PM, Reid DS, Eaves CJ: Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci USA 93:1470, 1996
25. 2-microglobulin-deficient NOD-scid mice. J Immunol 158:3578, 1997
26. Holyoake TL, Nicolini FE, Eaves CJ: Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood and adult marrow. Exp Hematol (in press)
27. - precursor present in human umbilical cord blood (UCB). Blood 92:367a, 1998 (abstr, suppl 1)
28. Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, Lider O, Alon R, Zipori D, Lapidot T: Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283:845, 1999
29. Muta K, Krantz SB, Bondurant MC, Dai C-H: Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation. Blood 86:572, 1995
30. Krystal G, Lam V, Dragowska W, Takahashi C, Appel J, Gontier A, Jenkins A, Lam H, Quon L, Lansdorp P: Transforming growth factor β1 is an inducer of erythroid differentiation. J Exp Med 180:851, 1994
31. Panzenbock B, Bartunek P, Mapara MY, Zenke M: Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro. Blood 92:3658, 1998