Clinical trials with Pseudomonas exotoxin immunotoxins

Current Topics in Microbiology and Immunology

Volumn 234, Issue , 1998, Pages 83-96

  Pai, L H ^a   Pastan, I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; IMMUNOTOXIN; INTERLEUKIN 2 RECEPTOR ANTIBODY; LMB 1 IMMUNOTOXIN; LMB 7 IMMUNOTOXIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B 3 LYS PSEUDOMONAS EXOTOXIN 38; MONOCLONAL ANTIBODY E 23(FV) PSEUDOMONAS EXOTOXIN 38; MONOCLONAL ANTIBODY OVB 3 PSEUDOMONAS EXOTOXIN; MUTANT PROTEIN; PROTEIN P53; PSEUDOMONAS EXOTOXIN; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA PSEUDOMONAS EXOTOXIN 40; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY SPECIFICITY; BREAST CARCINOMA; CAPILLARY LEAK SYNDROME; CLINICAL ARTICLE; CLINICAL TRIAL; COLON CARCINOMA; DOSE RESPONSE; DRUG CONJUGATION; DRUG MECHANISM; EDEMA; FEMALE; FEVER; HEADACHE; HUMAN; HYPOALBUMINEMIA; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATUMORAL DRUG ADMINISTRATION; KIDNEY CARCINOMA; MALE; NEUROTOXICITY; OLIGURIA; OVARY CARCINOMA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RASH; REVIEW; TRANSITIONAL CELL CARCINOMA;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS EXOTOXIN;

EID: 0031838498     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-72153-3_6     Document Type: Review

References (10)

1. Allured VS, Collier RJ, Carroll SF, McKay DB (1986) Structure of exotoxin A of Pseudomonas aeruginosa at 3.0 Angstrom resolution. Proc Natl Acad Sci USA 83:1320-1324
2. Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR (1992) Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proc Natl Acad Sci USA 89:5867-5871
3. Brinkmann U, Pai LH, FitzGerald DJ, Pastan I (1991) B3(Fv)-PE3SKDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice. Proc Natl Acad Sci USA 88:8616-8620
4. Chaudhary VK, FitzGerald DJ, Adhya S, Pastan I (1987) Activity of a recombinant fusion protein between transforming growth factor type a and Pseudomonas toxin. Proc Natl Acad Sci USA 84:4538-4542
5. Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I (1989) A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 339:394-397
6. Chaudhary VK,_Batra JK, Gallo M, Willingham MC, Pastan I (1990) A rapid method of cloning functional variable region antibody genes in E. coli as sinele-chain immunotoxins. Proc Natl Acad Sci USA 87:1066-1070
7. Debinski W, Puri RK, Kreitman RJ, Pastan I (1993) A wide range of human cancer express IL4 receptor that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin. J Biol Chem 268:14065-14070
8. FitzGerald DJ, Morris RE, Saelinger CB (1980) Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts. Cell 21:867-873
9. FitzGerald DJ, Trowbridge IS, Pastan I, Willingham MC (1983) Enhancement of toxicity of antitrans-ferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. Proc Natl Acad Sci USA 80:4134-4138
10. FitzGerald DJ, Willingham MC, Pastan I (1986) Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer. Proc Natl Acad Sci USA 83:6627-6630