Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in β1 integrin-mediated signaling in lymphocytes

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1365-1375

  Minegishi, Masayoshi ^a   Tachibana, Kouichi ^a   Sato, Toshiya ^a   Iwata, Satoshi ^a   Nojima, Yoshihisa ^b   Morimoto, Chikao ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING AFFINITY; CELL ADHESION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD29; BASE SEQUENCE; CELL ADHESION MOLECULES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-CRK; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 0029904694     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1365     Document Type: Article

References (39)

1. Hynes, R.O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:11-25.
2. Shimizu, Y., and S. Shaw. 1991. Lymphocyte interactions with extracellular matrix. FASEB J. 5:2292-2299.
3. Shuttle, S.J., M.J. Ginsberg, and J.S. Brugge. 1994. Adhesive signaling in platelets. Curr. Opin. Cell Biol. 3:695-704.
4. Matsuyama, T., A. Yamada, J. Kay, K.M. Yamada, S.K. Akiyama, S.F. Schlossman, and C. Morimoto. 1989. Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J. Exp. Med. 170:1133-1148.
5. Matsuyama, J.I., J.S. Berman, W.W. Cruikshank, C. Morimoto, and D.M. Center. 1992. Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J. Immunol. 148:1367-1374.
6. + T cell activation via the CS1 alternatively spliced domain of fibronectin. J. Exp. Med. 172:1185-1192.
7. Yamada, A., Y. Nojima, K. Sugita, N.H. Dang, S.F. Schlossman, and C. Morimoto. 1991. Cross-linking of VLA/CD29 molecule has a comitogenic effect with anti-CD3 on CD4 cell activation in serum-free culture system. Eur. J. Immunol. 21:319-325.
8. Yamada, A., T. Nikaido, Y. Nojima, S.F. Schlossman, and C. Morimoto. 1991. Activation of human CD4 T lymphocytes: interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor. J. Immunol. 146:53-56.
9. Ennis, E., R.R. Isberg, and Y. Shimizu. 1993. Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial β1 integrin ligand invasin. J. Exp. Med. 177:207-212.
10. Sato, T., K. Tachibana, Y. Nojima, N. D'Avirro, and C. Morimoto. 1995. Role of the VLA-4 molecule in T cell costimulation: identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4. J. Immunol. 155: 2938-2947.
11. Nojima, Y., D.M. Rothstein, K. Sugita, S.F. Schlossman, and C. Morimoto. 1992. Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein. J. Exp. Med. 175:1045-1053.
12. FAK) is tyrosine-phosphorylated after engagement of α4β1 and α5β1 integrins on human T-lymphoblastic cells. Cell. Immunol. 161:8-13.
13. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO (Eur. Mol. Biol. Organ.) J. 13:3748-3756.
14. Feller, S.M., B. Knudsen, and H. Hanafusa. 1995. Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk, indicate Crk-specific signaling pathways. Oncogene. 10:1465-1473.
15. Tanaka, S., T. Morishita, Y. Hashimoto, S. Hattori, S. Nakamura, and M. Matsuda. 1994. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of Crk and GRB2/ASH proteins. Proc. Natl. Acad. Sci. USA 91:3443-3447.
16. Simon, M.A., G.S. Dodson, and G.M. Rubin. 1993. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell. 73:169-177.
17. Gotoh, T., S. Hattori, S. Nakamura, H. Kitayama, M. Noda, Y. Takai, K. Kaibuchi, H. Matsui, O. Hatase, H. Takahashi et al. 1995. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 15:6746-6753.
18. Nojima, Y., N. Moritsugu, T. Mimura, K. Hamasaki, H. Furuya, R. Sakai, T. Sato, K. Tachibana, C. Morimoto, Y. Yazaki, and H. Hirai. 1995. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a src homology 3-contaning molecule having multiple src homology 2-binding motifs. J. Biol. Chem. 270:15398-15402.
19. Polte, T.R., and S.K. Hanks. 1995. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc. Natl. Acad. Sci. USA. 92:10678-10682.
20. Tachibana, K., T. Sato, N. D'Avirro, and C. Morimoto. 1995. Direct interaction of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J. Exp. Med. 182:1089-1099.
21. Songyang, Z., S.E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W.G. Haser, F. King, T. Roberts, S. Ratnofsky, R.J. Lechleider, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell. 72:767-778.
22. Tanaka, M., R. Gupta, and B.J. Mayer. 1995. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adaptor proteins. Mol. Cell. Biol. 15:6829-6837.
23. von Bonin, A., J. Wienands, U. Manning, J.F. Zuber, and G. Baumann. 1994. The βD-sheet residues of Lck-derived SH2 domain determine specificity of the interaction with tyrosine-phosphorylated ligands in Ramos B cells. J. Biol. Chem. 269: 33035-33041.
24. Manser, E., T. Leung, H. Salihuddin, Z. Zhao, and E. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (Lond.). 367:40-46.
25. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Smith. 1994. Current Protocols in Molecular Biology. John Wiley & Sons, Inc., New York, 6.7.1-8, 7.4.1-28, 9.2.1-6.
26. Tachibana, K., N. Takayama, K. Matsuo, S. Kato, K. Yamamoto, K. Ohyama, A. Umezawa, and T. Takano. 1993. Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc. Gene. 124:231-237.
27. Takebe, Y., M. Seiki., J. Fujisawa., P. Hoy, K. Yokota, K. Arai, M. Yoshida, and N. Arai. 1988. SRα promoter; an efficient and versatile mammalian cDNA expression system composed of the Simian Virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466-472.
28. Ishino, M., T. Ohba, H. Sasaki, and T. Sasaki. 1995. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene. 11:2331-2338.
29. Src. Mol. Cell. Biol. 14:1680-1688.
30. FAK. Mol. Cell. Biol. 14:147-155.
31. crk-2. J. Biol. Chem. 270:269-273.
32. Chen, Q., M.S. Kinch, T.H. Lin, K. Burridge, and R.L. Juliano. 1994. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269:26602-26605.
33. Egan, S.E., B.W. Giddings, M.W. Brooks, L. Buday, A.M. Sizeland, and R.A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (Lond.). 363: 45-51.
34. Kitayama, H., Y. Sugino, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A Ras-related gene with transformation suppressor activity. Cell. 56:77-84.
35. Chou, M.M., J.E. Fajardo, and H. Hanafusa. 1992. The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol. Cell. Biol. 12:5834-5842.
36. Feng, G.S., C.C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science (Wash. DC). 259:1607-1611.
37. Yamauchi, K., K.L. Milarski, A.R. Saltiel, and J.E. Pessin. 1995. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc. Natl. Acad. Sci. USA. 92:664-668.
38. Ren, R., Z.-S. Ye, and D. Baltimore. 1994. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8:783-795.
39. Mayer, B.J., H. Hirai, and R. Sakai. 1995. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr. Biol. 5:296-305.