Dynamic changes in p27kip1 variant expression in activated lymphocytes

Journal of Cellular Biochemistry

Volumn 83, Issue 3, 2001, Pages 380-389

  Yaroslavskiy, B ^a   Watkins, S C ^a   Alber, Sean ^a   Steinman, Richard A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Lymphocyte; p27kip1; Proteasome inhibitor; Variant

Indexed keywords

CYCLIN D3; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GAG PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 2; PROTEASOME; SUPERANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL GROWTH; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOCYTE ACTIVATION; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM;

BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; DOWN-REGULATION; FETAL BLOOD; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; MULTIENZYME COMPLEXES; MUSCLE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN ISOFORMS; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS; UMBILICAL CORD;

EID: 0034759183     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.1243     Document Type: Article

References (47)

1. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
2. Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells
3. The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A
4. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
5. p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells
6. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
7. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
8. Biological activity of p27kip1 and its amino- and carboxy-terminal domains in G2/M transition of Xenopus oocytes
9. Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma
10. Translational control of p27Kip1 accumulation during the cell cycle
11. Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1
12. Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)
13. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
14. Promoting apoptosis: A novel activity associated with the cyclin- dependent kinase inhibitor p27
15. The regulation of p27Kip1 expression following the polyclonal activation of murine G0 T cells
16. New functional activities for the p21 family of CDK inhibitors
17. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
18. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
19. Evidence for a p23 caspase-cleaved form of p27[KIP1] involved in G1 growth arrest
20. Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions
21. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
22. 73-kDa heat shock cognate protein interacts directly with P27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition
23. Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
24. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
25. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
26. Mitotic clonal expansion during preadipocyte differentiation: Calpain-mediated turnover of p27
27. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
28. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
29. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
30. Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1
31. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
32. Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells
33. Deregulated expression of p27(Kip1) in human breast cancers
34. Downregulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
35. Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex
36. Formation of p27-CDK complexes during the human mitotic cell cycle
37. Suppression of G-CSF-mediated Stat signalling by IL-3
38. p21WAF1 prevents down-modulation of the apoptotic inhibitor protein c-IAP1 and inhibits leukemic apoptosis
39. Regulation of p21(WAF1) expression during normal myeloid differentiation
40. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
41. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
42. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
43. Carboxyl-terminal domain of p27Kip1 activates CDC2
44. Role of proteasomes in T cell activation and proliferation
45. Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator- induced apoptosis and differentation in human myelomonocytic leukemia cells
46. Subcellular and cell-cycle expression profiles of CDK-inhibitors in normal differentiating myeloid cells
47. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein