Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1

Biochemical Journal

Volumn 353, Issue 1, 2001, Pages 51-57

  Hirano, K ^a   Hirano, M ^a   Zeng, Y ^a   Nishimura, J ^a   Hara, K ^a   Muta, K ^a   Nawata, H ^a   Kanaide, H ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cyclin dependent kinase inhibitor; Endothelial cells; Splice isoform

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR KIP1 P27; HYBRID PROTEIN; PROTEASOME; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA LIBRARY; ENZYME DEGRADATION; ENZYME INHIBITION; GROWTH INHIBITION; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; TISSUE SPECIFICITY;

ANIMALIA; SUIDAE;

EID: 0035155752     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3530051     Document Type: Article

References (37)

1. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
2. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
3. Kip1 for restriction point control of the fibroblast cell cycle
4. Inhibitors of mammalian G1 cyclin-dependent kinases
5. Kip1 gene promoter that lacks vitamin D response elements
6. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
7. Kip1 accumulation during the cell cycle
8. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
9. Kip1, a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
10. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
11. Kip1 is haplo-insufficient for tumour suppression
12. Kip1 activates CDC2
13. [Kip1] involved in G1 growth arrest
14. Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells
15. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
16. DNA sequencing with chain-terminating inhibitors
17. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding
18. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
19. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
20. Evidence for the presence of endothelial ETA receptor in endothelial cells in situ on the aortic side of porcine aortic valve
21. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
22. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
23. Kip1 gene to 12p13 and its analysis in leukemias
24. Kip1
25. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
26. Clp1
27. Kip1
28. Kip1 by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
29. Kip1-deficient mice
30. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
31. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286
32. Kip1, a cyclin-dependent kinase inhibitor
33. Promoting apoptosis: A novel activity associated with the cyclin-dependent kinase inhibitor p27
34. Kip1
35. Apoptosis of malignant cells in Hodgkin's disease is related to expression of the cdk inhibitor p27KIP1
36. CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene