Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase

Inflammation Research

Volumn 48, Issue 10, 1999, Pages 533-538

  Wang, S W ^a   Pawlowski, J ^a   Wathen, S T ^a   Kinney, S D ^a   Lichenstein, H S ^a   Manthey, C L ^b  

^a AMGEN INC   (United States)

^b 3 Dimensional Pharmaceuticals   (United States)

Author keywords

IL 6; Inflammation; MIP 1 ; Monocytes; mRNA stability; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; HUMAN CELL; MONOCYTE;

CELLS, CULTURED; CYTOKINES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; INTERLEUKIN-6; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGE INFLAMMATORY PROTEIN-1; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RNA STABILITY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032750228     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050499     Document Type: Article

References (22)

1. Lee CL, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-42.
2. Jackson JR, Bolognesc B, Hillegass L, Kassis S, Adams J, Griswold DE, et al. Pharmacological effects of SB220025, a selective inhibitor of p38-mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J Pharmacol Exp Ther 1998; 284: 687-92.
3. Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE. Pharmacologic profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther 1996; 279: 1453-61.
4. Young P, McDonnell P, Dunnington D, Hand A, Laydon J, Lee J. Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions 1993; 39: C67-9.
5. Pritchett W, Hand A, Shields J, Dunnington D. Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. J Inflam 1995; 45: 97-105.
6. Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BMJ, Brennan FM. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 1998; 160: 920-8.
7. Chin J, Kostura MJ. Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products. J Immunol 1993; 151: 5574-85.
8. Bayaert R, Cuenda A, Berghe WV, Plaisance S, Lee JC, Haegeman G, et al. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 1996; 15: 1914-23.
9. Manthey CL, Wang SW, Kinney SD, Yao Z. p38 mitogen-activated protein kinase plays a major role in LPS-induced mRNA expression in monocytes. J Leuk Biol 1998; 64: 409-16.
10. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 1997; 386: 296-9.
11. Wang X, Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 1996; 272: 1347-9.
12. Witmarsh AJ, Yang SH, Su MSS, Sharrocks AD, Davis RJ. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol Cell Biol 1997; 17: 2360-71.
13. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995; 270: 7420-6.
14. Ridley SH, Sarsfield SJ, Lee JC, Bigg HF, Cawston TE, Taylor DJ, et al. Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol 1997; 158: 3165-73.
15. Pouliot M, Baillargeon J, Lee JC, Cleland LG, James MJ. Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase. J Immunol 1997; 158: 4930-7.
16. Price MA, Cruzalegui RH, Treisman R. The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J 1996; 15: 6552-63.
17. Xu N, Chen CYA, Shyu AB. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol Cell Biol 1997; 17: 4611-21.
18. Kastelic T, Schnyder J, Leutwiler A, Traber R, Streit B, Niggli H, et al. Induction of rapid IL-1 beta mRNA degradation in THP-1 cells mediated through the AU-rich region in the 3′UTR by a radicicol analogue. Cytokine 1996; 8: 751-61.
19. Blum S, Forsdyke RE, Forsdyke DR. Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. DNA Cell Biol 1990; 9: 589-602.
20. Blomstom DC, Fahey D, Kutny R, Korant BD, Knight E Jr. Molecular characterization of the interferon-induced 15 kDa protein: Molecular cloning and nucleotide and amino acid sequence. J Biol Chem 1986; 261: 8811-6.
21. Hanauer A, Mandel JL. The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse. EMBO J 1984; 3: 2627-33.
22. Lieberman AP, Pitha PM, Shin ML. Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay. J Biol Chem 1991; 267: 2123-6.