Messenger ribonucleoprotein complexes containing human ELAV proteins: Interactions with cytoskeleton and translational apparatus

Journal of Cell Science

Volumn 111, Issue 2, 1998, Pages 183-197

  Antic, Oragana ^a   Keene, Jack D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cytoskeleton; ELAV; Hel N1; Hu; mRNP; RNA binding protein; RRM; Translation

Indexed keywords

COLCHICINE; CYTOCHALASIN; EDETIC ACID; MESSENGER RNA; PUROMYCIN; RIBONUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CYTOSKELETON; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROFILAMENT; MICROTUBULE; NERVE CELL; NONHUMAN; POLYSOME; PRIORITY JOURNAL; RAT; TUMOR CELL;

ANIMALIA; MAMMALIA;

EID: 0344351825     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.111.2.183     Document Type: Article

References (46)

1. Ainger, K., Avossa, D., Morgan, F., Hill, S.J., Barry, C., Barbarese, E. and Carson, J.H. (1993). Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes. J. Cell Biol. 123, 431-441.
2. Anant, S., Giannoni, F., Antic, D., DeMaria, C.T., Keene, J.D., Brewer, G. and Davidson, N.O. (1997). AU-rich RNA binding proteins Hel-N1 and AUF1 bind apolipoproteinB mRNA and inhibit posttranscriptional C to U editing. Nucleic Acids Symposium Series 34 (in press).
3. Andreu, J.M. and Timasheff, S.N. (1986). Tubulm-colchicme interactions and polymerization of the complex. Ann. NY Acad. Sci. 466, 676-689.
4. Antic, D. and Keene, J.D. (1997). ELAV RNA-binding proteins involved in growth, differentiation and post-transcriptional gene expression. Am. J. Hum. Gen. 61, 273-278.
5. Barbarese, E., Kuppel, D.E., Deutscher, M.P., Smith, C.L., Ainger, K., Morgan, F. and Carson, J.H. (1995). Protein translation components are colocalized in granules in oligodendrocytes. J. Cell Sci. 108, 2781-2790.
6. Bashaw, G.J., and Baker, B.S. (1997). The regulation of the Drosophila msl-2 gene reveals a function for sex-lethal in translational control. Cell 89, 789-798.
7. + mRNA with microtubules in cultured neurons. Neurons 12, 571-582.
8. Bier, E., Ackerman, L., Barbel, S., Jan, L. and Jan, Y. N. (1988.) Identification and characterization of a neuron-specific nuclear antigen in Dorosphila. Science 240, 913-916.
9. Burd, C.G. and Dreyfuss, G. (1994). Conserved structures and diversity of functions of RNA-binding proteins Science 265, 615-621.
10. Campos, A.R., Grossman, D. and White, K. (1985). Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system detects. A developmental-genetic analysis. J. Neurogenet. 2, 197-218.
11. Colombo, B., Felcetti, L. and Baglioni, C. (1965). Inhibition of protein synthesis by cycloheximide in rabbit reticulocytes. Biochem. Biophys. Res. Commun. 18, 389-395.
12. Cooper, J.A. (1987). Effects of cytochalasin and phalloidm on actin. J. Cell Biol. 105, 1473-1478.
13. Dreyfuss, G., Matunis, M.J., Pinol-Roma, S. and Burd, C.G. (1993) hnRNP proteins and the biogenesis of mRNA. Annu. Rev. Biochem. 62, 289-321.
14. Gao, F.-B., Carson, C., Levine, T. and Keene, J. (1994). Selection of a subset of mRNAs from combinatorial 3′ untranslated region libraries using neuronal RNA-binding protein Hel-N1. Proc. Nat. Acad. Sci. USA 91, 11207-11211.
15. + mRNA in granular RNP structures and are implicated in neuronal differentiation. J. Cell Sci. 109, 579-589.
16. Good, P.J. (1995). A conserved family of elav-like genes in vertebrates. Proc. Nat. Acad. Sci. USA 92, 4557-4561.
17. Gorlach, M., Burd, C.G. and Dreyfuss, G. (1994) The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. Exp. Cell Res. 211, 400-407.
18. Grollman, A.P. (1968). Inhibitors of protein biosynthesis. J. Biol. Chem. 243, 4089-4094.
19. Jacobson, A. and Peltz, S.W. (1996). Interrelationships of the pathways of mRNP decay and translation in eukaryotic cells. Anna. Rev. Biochem. 65, 693-740.
20. Jain, R.G., Andrews, L.G., McGowan, K.M., Pekala, P.H. and Keene, J.D. (1997). Ectopic expression of Hel-N1. an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytcs. Mol. Cell. Biol. 17, 954-962.
21. Kelley, R.L., Wang, J., Bell, L. and Kuroda, M.I. (1997) Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism. Nature 387, 195-199.
22. Kenan, D.J., Query, C.C. and Keene, J.D. (1991). RNA recognition: towards identifying determinants of specificity. Trends Biochem. Sci. 16, 214-220.
23. King, P.H., Levine, T.D., Fremeau, R.T., Jr. and Keene, J.D. (1994). Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3′ UTR of mRNA encoding the Id transcriptional repressor. J. Neurosci. 14, 1943-1952.
24. Kislauskis, E.H., Li, Z., Singer, R.H. and Taneja, K.L. (1993). Isoformspecific 3′-untranslated sequences sort α-cardiac and β-cytoplasmic actin messenger RNAs to different cytoplasmic compartments. J. Cell Biol. 123, 165-172.
25. Koushika, S.P., Lisbin, M.J. and White, K. (1996) ELAV. a Drosophila neuron-spccihc protein, mediates the generation of an alternatively spliced neural protein isoform. Curr. Biol. 6, 1634-1641.
26. Kramer, A. (1996). The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem. 65, 367-409.
27. Lenk, R., Ransom, L., Kaufmann, Y. and Penman, S. A. (1977). Cytoskeletal structure with associated polyribosomes obtained from HeLa cells. Cell 10, 67-78.
28. Levine, T.D., Gao, F.B., King, P.H., Andrews, L.G. and Keene, J.D. (1993). He1-N1: an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell. Biol. 13, 3494-3504.
29. Litman, P., Barg, J. and Ginzburg, I. (1994). Microtubules involved in the localization of tau mRNA in primary neuronal cell cultures. Neuron 13, 1463-1474.
30. Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J. and Furneaux, H. (1995). Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA. Neurology 45, 544-550.
31. Mattaj, I.W. (1993). RNA recognition: a family matter. Cell 73, 837-840.
32. Mayford, M., Baranes, D., Podsypanina, K. and Kandel, E.R. (1996). The 3′-untranslated region of CaMKIIa is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc. Nat. Acad. Sci. USA 93, 13250-13255.
33. Michael, W.M., Choi, M. and Dreyfuss, G. (1995). A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83, 415-422.
34. Myer, V.E., Fan, X. C. and Steitz, J.A. (1997). Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J. 16, 2130-2139.
35. Ornelles, D.A., Fey, E.G. and Penman, S. (1986) Cytochalasin releases mRNA from the cytoskeletal framework and inhibits, protein synthesis. Mol. Cell. Biol. 6, 1650-1662.
36. Pinol-Roma, S. and Dreyfuss. G. (1993). hnRNP proteins: localization and transport between the nucleus and the cytoplasm. Trends Cell Biol. 3, 151-155.
37. Rickwood, D., Ford, T. and Graham, J. (1982). Nycodenz: a new nonionic iodinated gradient medium. Anal. Biochem. 123, 23-31.
38. Robinow, S. and White, K. (1991). Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22, 443-461.
39. Spector, D.L., (1996). Nuclear organization and gene expression. Exp. Cell Res. 229, 189-197.
40. Steward, O. (1994). Dendrites as compartments for macromolecular synthesis. Proc. Acad. Sci. USA. 91, 10766-10768.
41. St Johnston, D. (1995). The intracellular localization of messenger RNAS. Cell 81, 161-170.
42. Sundell, C.L. and Singer, R.H. (1991). Requirement of microtilaments in sorting of actin messenger RNA. Science 53, 1275-1277.
43. Szabo, A., Dalmau, J., Manle. G., Rosenfeld, M., Wong, E., Henson, J., Posner, J.B. and Furneaux, H.M. (1991). HuD. a paraneoplastic encephalomyelitis antigen. contains RNA-binding doains and is homologous to Elav and Sex-lethal. Cell 67, 325-333.
44. Toczyski, D.P., Matera, A.G., Ward, D.C. and Steitz, J.A. (1994). The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proc. Nat. Acad, Sci. USA 91, 3463-3467.
45. Vallee, R.B. and Collins. C.A. (1986). Purification of microtubules and microtubule-associated proteins from sea urchin eggs and cultured mammalian cells using taxol. and use of exogenous taxol-stabilized brain microtubules for purifying microtubule-associated proteins. Methods Enzymol. 134, 116-127.
46. Yisraeli, J. K., Sokol, S. and Melton, D. A. (1990). A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and ancormg of Vg1 mRNA. Development 108, 289-298.