FcγRIIA exogenously expressed in HeLa cells activates the mitogen-activated protein kinase cascade by a mechanism dependent on the endogenous expression of the protein tyrosine kinase Syk

European Journal of Immunology

Volumn 31, Issue 5, 2001, Pages 1361-1369

  Renedo, Marta A ^a   Fernández, Nieves ^a   Sánchez Crespo, Mariano ^a,b  

^a Universidad de Valladolid and Consejo Superior de Investigaciones Científicas   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Cellular activation; Fc receptor; Inflammation; Protein kinase; Signal transduction

Indexed keywords

ARACHIDONIC ACID; CHEMOKINE; FC RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; OVALBUMIN; PHOSPHOTRANSFERASE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CROSS LINKING REAGENT; DNA BINDING PROTEIN; ENZYME PRECURSOR; FC GAMMA RECEPTOR IIA; I KAPPA B; LEUKOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PHOSPHOLIPASE A; SIGNAL PEPTIDE;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DNA SEQUENCE; EPITHELIUM CELL; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MIGRATION; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; ANIMAL; BIOSYNTHESIS; CAPPING PHENOMENON; ENZYME ACTIVATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; SWINE;

ANIMALS; ANTIGENS, CD; ARACHIDONIC ACID; CHEMOKINE CCL2; CROSS-LINKING REAGENTS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME PRECURSORS; HELA CELLS; HUMANS; I-KAPPA B PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOLIPASES A; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR AGGREGATION; RECEPTORS, IGG; SWINE; TRANSFECTION;

EID: 0034743949     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200105)31:5<1361::AID-IMMU1361>3.0.CO;2-7     Document Type: Article

References (43)

1. Clynes, R., Dumitru, C. and Ravetch, J. V., Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998. 279: 1052-1054.
2. Ravetch, J. V., Fc receptors: rubor redux. Cell 1994. 78: 553-560.
3. Sylvestre, D. L. and Ravetch, J. V., Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 1994. 265: 1095-1098.
4. Hazenbos, W. L., Gessner, J. E., Hofhuis, F. M., Kuipers, H., Meyer, D., Heijnen, I. A., Schmidt, R. E., Sandor, M., Capel, P. J., Daeron, M., van de Winkel, J. G. and Verbeek, J. S., Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice. Immunity 1996. 5: 181-188.
5. Ravetch, J. V. Fc receptors. Curr Opin. Immunol. 1997. 9: 121-125.
6. Daeron, M. Structural bases of FcγR functions. Int. Rev. Immunol. 1997. 16: 1-27.
7. Ravetch, J. V. and Clynes, R. A. Divergent roles for Fc receptors and complement in vivo. Annu. Rev. Immunol. 1998. 16: 421-432.
8. Brooks, D. G., Qiu, W. Q., Luster, A.D. and J. V. Ravetch, J. V., Structure and expression of human IgG FcγRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J. Exp. Med. 1989. 170: 1369-1385.
9. Van den Herik-Oudijk, I. E., Ter Bekke, M. W. H., Tempelman, M. J., Capel, P. J. A. and van de Winkel, J. G. J., Functional differences between two Fc receptor ITAM signaling motifs. Blood 1995. 86: 3302-3307.
10. Chacko, G. W., Duchemin, A. M., Coggeshall, K. M., Osborne, J. M., Brandt, J. T. and Anderson, C. L., Clustering of the platelet Fcγ receptor induces noncovalent association with the tyrosine kinase p72syk. J. Biol. Chem. 1994. 269: 32435-3240.
11. Agarwal, A., Salem, P. and Robbins, K. C., Involvement of p72syk, a protein-tyrosine kinase, in Fcγ receptor signaling. J. Biol. Chem. 1993. 268: 15900-15905.
12. Crowley, M. T., Costello, P. S., Fitzer-Attas, C. J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V. L. and DeFranco, A. L., A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 1997. 186: 1027-1039.
13. Turner, M., Schweighoffer, E., Colucci, F., Di Santo, J. P. and Tybulewicz, V. L., Tyrosine kinase SYK: essential functions for immunoreceptor signaling. Immunol. Today 2000. 21: 148-154.
14. Tsuchida, S., Yanagi, S., Inatome, R., Ding, J., Hermann, P., Tsujimura, T., Matsui, N. and Yamamura, Y., Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: Involvement of Syk in signaling events of hepatocytes. J. Biochem. (Tokyo) 2000. 127: 321-327.
15. Wang, H-y. and Malbon, C. C., Gsα repression of adipogenesis via Syk. J. Biol. Chem. 1999. 274: 32159-32166.
16. Yamada, T., Fujieda, S., Yanagi, S., Yamamura, H., Inatome, R., Sunaga, H., and Saito, H., Protein-tyrosine kinase syk expressed in human nasal fibroblasts and its effect on RANTES production. J. Immunol. 2001. 166: 538-543.
17. Coopman, P. J ., Do M. T., Barth, M., Bowden E. T., Hayes A. J., Basyuk, E., Blancato J. K., Vezza P. R., McLeskey S. W., Mangeat P. H. and Mueller S. C., The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000. 406: 742-747.
18. Alonso, A., Bayón, Y. and Sánchez Crespo, M., The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fcγ receptor activation: study of the signaling mechanism. Eur. J. Immunol. 1996. 26: 2165-2171.
19. Bayon, Y., Alonso, A. and Sánchez Crespo, M., Stimulation of Fcγ receptors in rat peritoneal macrophages induces the expression of nitric oxide synthase and chemokines by mechanisms showing different sensitivities to antioxidants and nitric oxide donors. J. Immunol 1997. 159: 887-894.
20. Alonso, A., Bayón, Y., Renedo, M. and Sánchez Crespo, M., Stimulation of FcγR receptors induces monocyte chemoattractant protein-1 (MCP-1 ) in the human monocytic cell line THP-1 by a mechanism involving IκB-α degradation and formation of p50/ p65 NF-κB/Rel complexes. Int. Immunol. 2000. 12: 547-554.
21. Fleit, H. B. and Kobasiuk, C. D., The human monocyte-like cell line THP-1 expresses FcγRI and FcγRII. J. Leukoc. Biol. 1991. 49: 556-565.
22. Bredius, R. G., Derkx, B. H., Fijen, C. A., de Wit, T, P., de Haas, M., Weening, R.S., van de Winkel, J. G. and Out, T. A. Fc gamma receptor IIa (CD32) polymorphism in fulminant meningococcal septic shock in children. J. Infect. Dis. 1994. 170: 848-853.
23. Worgall, S., Bezdicek, P., Kim, M.K., Park, J.S., Singh, R., Christofidou-Solomidou, M., Prince, A., Kovesdi, I., Schreiber, A. D. and Crystal, R. G., Augmentation of pulmonary host defense against pseudomonas by FcγRIIA cDNA transfer to the respiratory epithelium. J. Clin. Invest. 1999. 104: 409-418.
24. Bezdicek, P., Worgall, S., Kovesdi, I., Kim, M.K., Park, J. G., Vincent, T., Leopold, P. L, Schreiber, A. D. and Crystal, R. G., Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcγRIIA cDNA to the liver. Blood 1999. 94: 3448-3855.
25. Yin, M-J., Yamamoto, Y. and Gaynor, R. B., The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 1998. 396: 77-80.
26. Ueda, A., Ishigatsubo, Y., Okubo, T. and Yoshimura, T., Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-κB sites and NF-κB/Rel subunit specificity. J. Biol. Chem. 1997. 272: 31092-31099.
27. Denney, C. F., Eckmann, L. and Reed, S. L., Chemokine secretion of human cells in response to Toxoplasma gondii infection. Infect. Immun. 1999. 67: 1547-1552.
28. 2 activity. J. Biol. Chem. 1999. 274:17202-17208.
29. Rose, D. M., Winston, B. W., Chan, E. D., Riches, D. W. H., Gerwins, P., Johnson, G. L. and Henson, P. M., FcγR cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42-MAP kinase in FcγR-stimulated TNF-α synthesis. J. Immunol. 1997. 158: 3433-3438.
30. Ierino, F. L., Hulett, M. D., McKenzie, I. F. and Hogarth, P. M., Mapping epitopes of human FcγRII (CDw32) with monoclonal antibodies and recombinant receptors. J. Immunol. 1993. 150: 1794-1803.
31. Williams, S., Couture, C., Gilman, J., Jascur, T., Deckert, M., Altman, A, and Mustelin, T., Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JcaM1 cells by Syk. Eur. J. Biochem. 1997. 245: 84-90.
32. Taniguchi, T., Kobayashi, T., Kondo, J., Takahashi, K., Nakamura, M., Suzuki, J., Nagai, K., Yamada, T., Nakamura, S. and Yamamura, H., Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J. Biol. Chem. 1991. 266: 15790-15796.
33. Indik, Z. K., Park, J. G., Hunter, S. and Schreiber, A. D., The molecular dissection of Fcγ receptor mediated phagocytosis. Blood 1995. 86: 4389-4399.
34. Hunter, S., Kamoun, M. and Schreiber, A. D., Transfection of a Fcγ receptor cDNA induces T cells to become phagocytic. Proc. Natl. Acad. Sci. USA 1994. 91: 10232-10236.
35. Peters, J. D., Furlong, M. T., Asai, D. J., Harrison, M. L., and Geahlen, R. L., Syk, activated by cross-linking the B cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates α-tubulin on tyrosine. J. Biol. Chem. 1996. 271: 4755-4762.
36. 2 is phosphorylated and activated by MAP kinase. Cell 1993. 72: 269-278.
37. 2 pathway by FcεRI is not shared by a G-protein-coupled receptor. J. Biol. Chem. 1995. 270: 10960-10967.
38. 2. J. Biol. Chem. 1996. 271: 27723-27729.
39. 2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1. Biochem. J. 1997. 328: 263-269.
40. Stenton, G. R., Kim, M. K., Nohara, O., Chen, C. F., Hirji, N., Wills, F. L., Gilchrist, M., Hwang, P. H., Park, J. G., Finlay, W., Jones, R. L., Befus, A. D. and Schreiber, A. D., Aerosolized syk antisense suppresses syk expression, mediator release from macrophages, and pulmonary inflammation. J. Immunol. 2000. 164: 3790-3797.
41. Bayón, Y., Alonso, A. and Sánchez Crespo, M., 4-Trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation. Br. J. Pharmacol. 1999. 126: 1359-1366.
42. Couture, C., Baier, G., Oetken, C., Williams, S., Telford, D., Marie-Cardine, A., Baier-Bitterlich, G., Fischer, S., Burn, P., Altman, A. and Mustelin, T., Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol. Cell. Biol. 1994. 14: 5249-5258.
43. Law, C.-L., Sidorenko, S. P., Chandran, K. A., Draves, K. E., Chan, A. C., Weiss, A., Edelhoff, S., Disteche, C. M. and Clark, E., Molecular cloning of human Syk: A B cell protein tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J. Biol. Chem. 1994. 269: 12310-12319.