Decreased serotonin transporter binding in unaffected relatives of manic depressive patients

Biological Psychiatry

Volumn 46, Issue 12, 1999, Pages 1703-1706

  Leboyer, Marion ^a,c   Quintin, Philippe ^a,b   Manivet, Philippe ^d   Varoquaux, Odile ^e   Allilaire, Jean François ^b   Launay, Jean Marie ^d  

^a CNRS UMR 7593 Vulnerabilite Adaptation et Psychopathologie   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c HENRI MONDOR HOSPITAL   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e CENTRE HOSPITALIER DE VERSAILLES   (France)

Author keywords

Endophenotype; Manic depressive illness; Serotonin; Serotonin transporter gene

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; IMIPRAMINE; SEROTONIN; SEROTONIN TRANSPORTER;

ARTICLE; BINDING AFFINITY; DRUG BINDING; MANIC DEPRESSIVE PSYCHOSIS; PHENOTYPE; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; THROMBOCYTE;

ADRENERGIC UPTAKE INHIBITORS; ADULT; BIOLOGICAL MARKERS; BIPOLAR DISORDER; BLOOD PLATELETS; CARRIER PROTEINS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROXYINDOLEACETIC ACID; IMIPRAMINE; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PHENOTYPE; PILOT PROJECTS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0033405868     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00178-X     Document Type: Article

References (25)

1. Bellivier F, Henry C, Szoke A, Schurhoff F, Nosten-Bertrand M, Feingold J, Launay JM, Leboyer M, Laplanche JL (1998): Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 255:143-146.
2. Collier DA, Arrantz MJ, Sham P, Battersby S, Gill P, Aitchison KJ et al (1996): A VNTR in the serotonin transporter gene is a potential susceptibility factor for bipolar affective disorder. NeuroReport 7:1675-1679.
3. Ellis PM, Salmond C (1994): Is platelet imipramine binding reduced in depression? A Meta-analysis. Biol Psychiat 36: 292-299.
4. Hamilton M (1960): A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62.
5. 3H] imipramine binding to previously frozen platelets membranes from depressed patients, before and after treatment. Br J Psychiatry 157:208-215.
6. Heils A, Teufel A, Petri S, Stöber G, Reiderer P, Bengel D, Balling U, Riederer P, Lesch KP (1996): Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
7. Greenberg BD, McMahon FJ, Murphy DL (1998): Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls. Mol Psychiatry 3:186-189.
8. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T, Hirose T, Nanko S (1997): Serotonin transporter gene polymorphisms: ethnic differences and possible association with bipolar affective disorder. Mol Psychiatry 2:457-462.
9. Launay JM, Geoffroy C, Mutel V, Buckle M, Cesura A, Alouf JE, Da Prada M (1992): One-step purification of the serotonin transporter located at the human plasma membrane. J Biol Chem 267:11344-11351.
10. Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J (1998): Psychiatry genetics: Search for phenotypes. Trends Neurosci 21:102-105.
11. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer, DH, Murphy DL (1996): Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
12. Lesch KP, Franzek E, Gross J, Wolozin BL, Riederer P, Murphy DL (1995): Primary structure of the serotonin transporter in unipolar and bipolar disorder. Biol Psychiatry 37:215-233.
13. Lesch KP, Mössner R (1998): Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44:179-192.
14. Malison RT, Price L, Berman R, Van Dyck CH, Pelton G, Carpenter L, Sanacora G, Owens M, Nemeroff C, Rajeevan N, Baldwin R, Seibyl J, Innis R, Charney D (1998): Reduced brain serotonin transporter availability in major depression as measured by (123 I)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane and single photon emission computed tomography Biol Psychiatry 44:1090-1098.
15. Marazitti D, Lenzi A, Galli L, San Martino S, Cassano GB (1991): Decreased platelet serotonin uptake in bipolar I patients. Int Clin Psychopharmacol 6:25-30.
16. Matuchansky C, Launay JM (1995): Serotonin, catecholamines, and spontaneous midgut carcinoid flush. Studies in plasma and whole blood from flushing and nonflushing sites. Gastroenterology 108:743-751.
17. Meltzer HY, Arora RC (1988): Genetic control of serotonin uptake in blood platelets: A twin study. Psychiatry Res 24:263-269.
18. Nemeroff C, Knight D, Franks J, Craighead WE, Krishnana R (1994): Further studies on platelet serotonin transporter binding in depression. Am J Psychiatry 151:1623-1625.
19. Nurnberger JI, Blehar MC, Kaufman CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T (1994): Diagnostic interview for genetic studies. Rationale, unique features and training. Arch Gen Psychiatry 5:849-864.
20. Ott J (1995): Linkage analysis with biological markers. Hum Hered 45:169-174.
21. Owens MJ, Nemeroff CB (1994): Role of serotonin in pathophysiology of depression: Focus on the serotonin transporter. Clin Chem 40:288-295.
22. 2+ response, and 5-HT content in winter seasonal affective disorder. Biol Psychiatry 36:458-466.
23. Ravindran AV, Chudzik J, Bialik RJ, Lapierre YD, Hrdina PD (1994): Platelet serotonin measures in primary dysthymia. Am J Psychiatry 151:1369-71.
24. Tuomisto J, Tukiainen E (1976): Decreased uptake of 5-hydoxytryptamine in blood platelets from depressed patients. Nature 262:596-598.
25. Walker RF, Friedman DW, Jimenez A (1983): A modified enzymatic-isotopic microassay for serotonin (5-HT) using 5-HT-acetyl-transferase partially purified from Drosophilia. Life Sci 33:1915-1924.