Temperature-sensitive mutants of p53 homologs

Biochemical and Biophysical Research Communications

Volumn 279, Issue 3, 2000, Pages 1001-1010

  Pochampally, Radhika ^a   Li, Changgong ^a   Lu, Wenge ^a   Chen, Lihong ^a   Luftig, Ronald ^b   Lin, Jiayuh ^c   Chen, Jiandong ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

MDM2; Mutant; p51; p53; p63; p73; Temperaturesensitive

Indexed keywords

ALANINE; AMINO ACID; DNA; LEUCINE; PROTEIN P53; PROTEIN P63; PROTEIN P73;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TEMPERATURE SENSITIVE MUTANT; TUMOR SUPPRESSOR GENE;

MURINAE;

EID: 0034731309     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4056     Document Type: Article

References (42)

1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
2. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
3. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
4. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
5. p73 is a human p53-related protein that can induce apoptosis
6. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
7. Mdm2 promotes the rapid degradation of p53
8. Regulation of p53 stability by mdm2
9. MDM2 suppresses p73 function without promoting p73 degradation
10. Mdm2 binds p73 alpha without targeting degradation
11. Promoter specificity and stability control of the p53-related protein p73
12. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
13. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death [In Process Citation]
14. p63 is a p53 homologue required for limb and epidermal morphogenesis
15. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
16. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
17. The p53 gene family
18. The expression of p73 is increased in lung cancer, independent of p53 gene alteration
19. Elevated and biallelic expression of p73 is associated with progression of human bladder cancer
20. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
21. Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas
22. Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma
23. Role for the p53 homologue p73 in E2F-1F-induced apoptosis
24. A common E2F-1F and p73 pathway mediates cell death induced by TCR activation
25. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
26. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
27. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
28. Wild-type p53 negatively regulates the expression of a microtubule-associated protein
29. Mapping of the p53 and mdm-2 interaction domains
30. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
31. p53 activates a MDM2-selective caspase in the absence of apoptosis
32. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
33. A temperature-sensitive mutant of human p53
34. Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
35. Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line
36. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent
37. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell
38. Regulation of mutant p53 temperature-sensitive DNA binding
39. Induction of neuronal differentiation by p73 in a neuroblastoma cell line
40. Comparative analysis of p73 and p53 regulation and effector functions
41. Cell cycle inhibitors (p27Kip1 and p21CIP1) cause hypertrophy in LLCPK1 cells
42. Induction of the growth inhibitor IGF-binding protein 3 by p53