The novel non-competitive N-methyl-D-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A microdialysis study in rats

Neuroscience Letters

Volumn 289, Issue 1, 2000, Pages 49-52

  Laplanche, L ^a   Kamenka, J M ^a   Barbanel, G ^a  

^a INSTITUT CHARLES GERHARDT   (France)

Author keywords

Alcohol; Dizocilpine; Glutamate; Hydroxyl radicals; N methyl D aspartate receptors, Non N methyl D aspartate receptors; Oxidative stress

Indexed keywords

ALCOHOL; DIZOCILPINE; GACYCLIDINE; GLUTAMIC ACID; HYDROXYL RADICAL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BINDING, COMPETITIVE; CORPUS STRIATUM; CYCLOHEXANES; CYCLOHEXENES; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATES; HYDROXYL RADICAL; MALE; MICRODIALYSIS; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034726120     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01259-3     Document Type: Article

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