Alpha-phenyl-N-tert-butylnitrone attenuates excitotoxicity in rat striatum by preventing hydroxyl radical accumulation

Free Radical Biology and Medicine

Volumn 23, Issue 7, 1997, Pages 1031-1034

  Lancelot, Eric ^a   Revaud, Marie Louise ^a   Boulu, Roger G ^a   Plotkine, Michel ^a   Callebert, Jacques ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Phenyl N tert butylnitrone; Excitotoxicity; Free radicals; Hydroxyl radicals; Microdialysis; Rat; Striatum

Indexed keywords

EXCITOTOXIN; GLUTAMIC ACID; HYDROXYL RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; MALE; MICRODIALYSIS; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STROKE; TOXICITY;

ANIMALS; CORPUS STRIATUM; EXCITATORY AMINO ACIDS; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; MALE; MICRODIALYSIS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; OXIDATIVE STRESS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SPIN LABELS;

EID: 0030868417     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00128-7     Document Type: Article

References (25)

1. Beal M. F. Mechanisms of excitotoxicity in neurologic diseases. FASEB J. 6:1992;3338-3344.
2. Choi D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
3. Coyle J. T., Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-695.
4. Bondy S. C., LeBel C. P. The relationship between excitotoxicity and oxidative stress in the central nervous system. Free Radic. Biol. Med. 14:1993;633-642.
5. Cao X., Phillis J. W. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644:1994;267-272.
6. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
7. Nakao N., Grasbon-Frodl E. M., Widner H., Brundin P. Antioxidant treatment protects striatal neurons against excitotoxic insults. Neuroscience. 73:1996;185-200.
8. Schulz J. B., Henshaw D. R., Siwek D., Jenkins B. G., Ferrante R. J., Cipolloni P. B., Kowall N. W., Rosen B. R., Beal M. F. Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64:1995;2239-2247.
9. Boisvert D. P. In vivo generation of hydroxyl radicals during glutamate exposure. Globus M., Dietrich W. D. The role of neurotransmitters in brain injury. 1992;361-366 Plenum Press, New York.
10. Lancelot E., Callebert J., Plotkine M., Boulu R. G. Striatal dopamine participates in glutamate-induced hydroxyl radical generation. Neuroreport. 6:1995;1033-1036.
11. Yang C. S., Tsai P. J., Lin N. N., Liu L., Kuo J. S. Elevated extracellular glutamate levels increased the formation of hydroxyl radical in the striatum of anesthetized rat. Free Radic. Biol. Med. 19:1995;453-459.
12. Fujisawa H., Dawson D., Browne S. E., MacKay K. B., Bullock R., McCulloch J. Pharmacological modification of glutamate neurotoxicity in vivo. Brain Res. 629:1993;73-78.
13. +. J. Neural Transm. (Gen. Sect.). 89:1992;139-145.
14. Halliwell B., Harparkash K., Ingelman-Sundberg M. Hydroxylation of salicylate as an assay for hydroxyl radicals: a cautionary note. Free Radic. Biol. Med. 10:1991;439-441.
15. Dykens J. A., Stern A., Trenkner E. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury. J. Neurochem. 498:1987;1222-1228.
16. Favit A., Nicoletti F., Scapagnini U., Canonico P. L. Ubiquinone protects cultured neurons against spontaneous and excitotoxin-induced degeneration. J. Cereb. Blood Flow Metab. 12:1992;638-645.
17. Majewska M. D., Bell J. A. Ascorbic acid protects neurons from injury induced by glutamate and NMDA. Neuroreport. 1:1990;194-196.
18. Monyer M., Hartley D. M., Choi D. W. 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures. Neuron. 5:1990;121-126.
19. Lafon-Cazal M., Culcasi M., Gaven F., Pietri S., Bockaert J. Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells. Neuropharmacology. 32:1993;1259-1266.
20. Lancelot E., Callebert J., Revaud M. L., Boulu R. G., Plotkine M. Hydroxyl radicals are not implicated in the necrosis induced by an intrastriatal perfusion of glutamate. J. Cereb. Blood Flow Metab. 15:(Suppl. 1):1995;S86.
21. Anderson D. E., Yuan X. J., Tseng C. M., Rubin L. J., Rosen G. M., Tod M. L. Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals. Biochem. Biophys. Res. Commun. 193:1993;878-885.
22. Folbergrova J., Zhao Q., Katsura K., Siesjo B. K. α-Phenyl-N-tert-butyl nitrone improves recovery of energy metabolism following 2 hrs of middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 15:(Suppl. 1):1995;S93.
23. Inanami O., Kuwabara M. α-Phenyl N-tert-butyl nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats. Free Radic. Res. 23:1995;33-39.
24. Schulz J. B., Matthews R. T., Jenkins B. G., Brar P., Beal M. F. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. J. Cereb. Blood Flow Metab. 15:1995;948-952.
25. Landlot H., Lutz T. W., Langemann H., Stauble D., Mendelowitsch A., Gratzl O., Honegger C. G. Extracellular antioxidants and amino acids in the cortex of the rat: Monitoring by microdialysis of early ischemic changes. J. Cereb. Blood Flow Metab. 12:1992;96-102.