Comparison of the novel drug Ensaculin with MK-801 on the reduction of hydroxyl radical production in rat striatum after local application of glutamate

Brain Research

Volumn 857, Issue 1-2, 2000, Pages 165-171

  Teismann, Peter ^a   Ferger, Boris ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Ensaculin; Excitotoxicity; Glutamate; Hydroxyl radical; Microdialysis; Neuroprotection

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; ANSECULIN; DIZOCILPINE; GLUTAMIC ACID; HYDROXYL RADICAL; SALICYLIC ACID; SODIUM CHLORIDE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZOPYRANS; CORPUS STRIATUM; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GENTISATES; GLUTAMIC ACID; HYDROXYBENZOIC ACIDS; HYDROXYL RADICAL; MALE; MICRODIALYSIS; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033954851     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02395-1     Document Type: Article

References (48)

1. Boireau A., Dubödat P., Bordier F., Peny C., Miquet J.-M., Durand G., Meunier M., Doble A. Riluzole and experimental parkinsonism: antagonism of MPTP-induced decrease in central dopamine levels in mice. NeuroReport. 5:1994;2657-2660.
2. Brouillet E., Beal M.F. NMDA antagonists partially protect against MPTP induced neurotoxicity in mice. NeuroReport. 4:1993;387-390.
3. Camins A., Sureda F.X., Gabriel C., Pallas M., Escubedo E., Camarasa J. Effect of 1-methyl-4-pyridinium (MPP+) on mitochondrial membrane potential in cerebellar neurons: interaction with the NMDA receptor. J. Neural Transm. 104:1997;569-577.
4. Chan P., Di Monte D.A., Langston J.W., Janson A.M. (+)MK-801 does not prevent MPTP-induced loss of nigral neurons in mice. J. Pharmacol. Exp. Ther. 280:1997;439-446.
5. +. Free Radical Biol. Med. 13:1992;581-583.
6. Choi D. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
7. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 262:1993;689-695.
8. Dexter D.T., Wells F.R., Lees A.J., Agid F., Agid Y., Jenner P., Marsden C.D. Increased nigral iron content and alterations in other metal irons occurring in brain in Parkinson's disease. J. Neurochem. 52:1989;1830-1836.
9. L.L. Dugan, D.W. Choi, Hypoxic-ischemic brain injury and oxidative stress. in: G.J. Siegel, B.W. Agranoff, R.W. Albers, S.K. Fisher, M.D. Uhler (Eds.), Basic Neurochemistry, Raven Press, New York, 1999, pp. 711-729.
10. +: implications for neurodegeneration. J. Neurochem. 63:1994;584-591.
11. Ehmann W.D., Markesbery W.R., Alauddin M., Hossain T.I.M., Brubaker E.H. Brain trace elements in Alzheimer's disease. Neurotoxicology. 7:1986;197-206.
12. Ferger B., van Amsterdam C., Seyfried C., Kuschinsky K. Effects of α-phenyl-tert-butylnitrone and selegiline on hydroxyl free radicals in rat striatum produced by local application of glutamate. J. Neurochem. 70:1998;276-280.
13. Floyd R.A., Watson J.J., Wong P.K. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate products. J. Biochem. Biophys. Methods. 10:1984;221-235.
14. Gunasekar P.G., Kanthasamy A.G., Borowitz J.L., Isom G.E. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death. J. Neurochem. 65:1995;2016-2021.
15. Halliwell B., Kaur H., Ingelmann-Sundberg M. Hydroxylation of salicylate as an assay for hydroxyl radicals: a cautionary note. Free Radical Biol. Med. 10:1991;439-441.
16. Hammer B., Parker W.D. Jr., Bennett J.P. Jr. NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C. NeuroReport. 5:1993;72-74.
17. Hilgert M., Nöldner M., Chatterjee S.S., Klein J. KA-672 inhibits rat brain acetylcholine esterase in vitro but not in vivo. Neurosci. Lett. 263:1999;193-196.
18. Ingelman-Sundberg M., Kaur H., Terelius Y., Persson J.O., Halliwell B. Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted. Biochem. J. 276:1991;753-757.
19. Kupsch A., Löschmann P.-A., Sauer H., Arnold G., Renner P., Pufal D., Burg M., Wachtel H., ten Bruggencate G., Oertel W.H. Do NMDA receptor antagonists protect against MPTP toxicity? Biochemical and immunocytochemical analyses in black mice. Brain Res. 592:1992;74-83.
20. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
21. Lan J., Jiang D.H. Desferroxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104:1997;469-481.
22. Lan J., Jiang D.H. Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease. J. Neural Transm. 104:1997;649-660.
23. Lancelot E., Revaud M.-L., Roger G.B., Plotkine M., Callebert J. Alpha-phenyl-N-tert-butylnitrone attenuates excitotoxicity in rat striatum by preventing hydroxyl radical accumulation. Free Radical Biol. Med. 23:1997;1031-1034.
24. Lancelot E., Revaud M.-L., Roger G.B., Plotkine M., Callebert J. A microdialysis study investigating the mechanisms of hydroxyl radical formation in rat striatum exposed to glutamate. Brain Res. 809:1998;294-296.
25. Lishko P.V., Maximyuk O.P., Chatterjee S.S., Nöldner M., Krishtal O.A. The putative cognitive enhancer KA-672.HCl is an uncompetitive voltage dependent NMDA receptor antagonist. NeuroReport. 9:1998;4193-4197.
26. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radical Biol. Med. 23:1997;134-147.
27. Murphy T.H., Miyamoto M., Sastre A., Schnaar R.L., Coyle J.T. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2:1989;1547-1558.
28. Nappi A.J., Vass E., Prota G., Memoli S. The effects of hydroxyl radical attack on dopa, dopamine, 6-hydroxydopa, and 6-hydroxydopamine. Pigm. Cell Res. 8:1995;283-293.
29. Nöldner M., Hauer H., Chatterjee S.S. Anseculin hydrochloride. Drugs Future. 21:1996;779-781.
30. Obata T., Chiueh C.C. In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+. J. Neural Transm.: Gen. Sect. 89:1992;139-145.
31. Okazaki S., Nishida Y., Kawai H., Saito S. Acute neurotoxicity of L-glutamate induced by impairment of the glutamate uptake system. Neurochem. Res. 21:1996;1201-1207.
32. Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 16:1993;439-444.
33. Olney J.W. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science. 164:1969;719-721.
34. J.W. Olney, Excitotoxicity and ischemic brain damage in infancy and adulthood, in: J. Krieglstein, H. Oberpichler (Eds.), Pharmacology of Cerebral Ischemia, Wiss. Verlagsgesellschaft, Stuttgart, 1990, pp. 153-167.
35. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1982.
36. Pelligrini-Giampietro D.E., Cherici G., Alesiani M., Carlà V., Moroni F. Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation. J. Neurochem. 51:1988;1960-1963.
37. Praprotnik D., Smith M.A., Richey P.L., Vinters H.V., Perry G. Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease an index of oxidative stress. Acta Neuropathol. 91:1996;1-5.
38. Riederer P., Sofic E., Rausch W.D., Schmidt B., Reynolds G.P., Jellinger K., Youdim M.H.B. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem. 52:1989;515-520.
39. Samudralwar D.L., DiPrete C.C., Ni B.F., Ehmann W.D., Markesbery W.R. Elemental imbalances in the olfactory pathway in Alzheimer's disease. J. Neurol. Sci. 130:1995;139-145.
40. + neurotoxicity by N-methyl-D-aspartate antagonists. Brain Res. 586:1992;203-207.
41. Schulz J.B., Henshaw D.R., Siwek D., Jenkins B.G., Ferrante R.J., Cipollini P.B., Kowall N.W., Rosen B.R., Beal M.F. Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64:1995;2239-2247.
42. Sengstock G.J., Olanow C.W., Menzies R.A., Dunn A.J., Arendesh G.W. Infusion of iron into rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers. J. Neurosci. Res. 35:1993;67-82.
43. P. Teismann, B. Ferger, In vivo effects of the putative cognitive enhancer KA-672.HCl in comparison with 8-hydroxy-2-(di-N-propylamino)tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions, Prog. Neuro-Psychopharmacol. Biol. Psychiat., in press.
44. Thompson C.M., Markesbery W.R., Ehmann W.D., Mao Y.-X., Vance D.E. Regional brain-trace element studies in Alzheimer's disease. Neurotoxicology. 9:1988;1-8.
45. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature. 349:1991;414-418.
46. White R.J., Reynolds I.J. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16:1996;5688-5697.
47. Yang C.-S., Tsai P.-J., Liu L., Kuo J.-S. Elevated extracellular glutamate levels increased the formation of hydroxyl radical in the striatum of anesthetized rat. Free Radical Biol. Med. 19:1995;453-459.
48. Zuddas A., Oberto G., Vaglini F., Fascetti F., Fornai F., Corsini G.U. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates. J. Neurochem. 59:1992;733-739.