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Volumn 10, Issue 5, 1998, Pages 513-517

Strategies for tolerance induction in nonhuman primates

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GLYCOPROTEIN GP 39; IMMUNOSUPPRESSIVE AGENT; IMMUNOTOXIN; MONOCLONAL ANTIBODY CD3; OKT 4; T LYMPHOCYTE RECEPTOR;

EID: 0031756735     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80216-1     Document Type: Article
Times cited : (27)

References (26)
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    • of special interest. This study examined the potential for donor bone marrow (BM) transplantation to induce tolerance in utero. T-cell-depleted paternal BM was injected in utero into the peritoneal cavity of two female fetal rhesus monkeys at day 61 of gestation. Chimerism was detected as early as six weeks after birth and until two years of age. In contrast to controls, chimeric monkeys had prolonged graft survival and no clinical evidence of graft failure for at least seven weeks; however, biopsies performed one - four weeks post-transplant showed signs of moderate/acute rejection. Consistent with these in vivo findings, in vitro mixed lymphocyte reactions to the donor cells were reduced compared with responses to third-party cells.
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    • Mychaliska, G.B.1    Rice, H.E.2    Tarantal, A.F.3    Stock, P.G.4    Capper, J.5    Garovoy, M.R.6    Olson, J.L.7    Cowan, M.J.8    Harrison, M.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.