Structural variants of the vitamin d analogue EB1089 reduce its ligand sensitivity and promoter selectivity

Journal of Cellular Biochemistry

Volumn 71, Issue 3, 1998, Pages 340-350

  Quack, Marcus ^a   Clarin, Andreas ^a   Binderup, Ernst ^b   Björkling, Fredrik ^b   Mørk Hansen, Christina ^b   Carlberg, Carsten ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LEO Pharmaceutical Products ^*  (Denmark)

Author keywords

Gene regulation; Ligand binding; Ligand dependent gel shift assay; Limited protease digestion; Vitamin D analogues; Vitamin D receptor

Indexed keywords

CALCIUM; VITAMIN D RECEPTOR;

ARTICLE; CONFORMATIONAL TRANSITION; GENE EXPRESSION REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN DNA BINDING; RECEPTOR AFFINITY;

CALCITRIOL; CELL DIVISION; DIMERIZATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TRYPSIN; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 0032401684     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19981201)71:3<340::AID-JCB3>3.0.CO;2-C     Document Type: Article

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