The anti-proliferative and differentiation-inducing effects of vitamin d analogs are not determined by the binding affinity for the vitamin D receptor alone

Journal of Investigative Dermatology Symposium Proceedings

Volumn 1, Issue 1, 1996, Pages 44-48

  Hansen, Christina Mørk ^a   Mathiascn, Ida S ^a   Binderup, Lise ^a  

^a Leo Pharmaceutical Products ^*  (Denmark)

Author keywords

Keratinocyteslvitamin d receptor trait scription

Indexed keywords

CALCIPOTRIOL; CALCITRIOL; CALCITRIOL RECEPTOR; DRUG DERIVATIVE; EB 1213;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DRUG EFFECT; HUMAN; KERATINOCYTE; METABOLISM; TRANSACTIVATION;

BINDING SITES; CALCITRIOL; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; HUMANS; KERATINOCYTES; RECEPTORS, CALCITRIOL; TRANS-ACTIVATION (GENETICS);

EID: 0030112250     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Achtstaetter T, Hatzfeld M, Quinlan RA, Parmelee DC, Franke W\V: Separation of cytokeratin polypeptides by gel electrophoretic and Chromatographie techniques and their identification by immunoblotting. Cancer Res 46:355-371, 1986
2. Bartek J, Taylor-Papadimitriou J, Miller N, Millis R: Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours. IntJ Cancer 36:299-306, 1985
3. Berger U, McClelland RA, Wilson P, Greene GL, Haussler MR, Pike JW, Colston KW, Easton D, Coombes RC: Immunocytochemical determination of estrogen receptor, progesterone receptor, and 1,25-dihydroxyvitamin D3 receptor in breast cancer and relationship to prognosis. Cancer Res 51:239-244, 1991
4. Berth-Jones J, Fletcher A, Hutchinson PE: Epidermal cytokeratin and immunocyte response during treatment of psoriasis with calcipotriol and betaniethasone valerate. BrJ Dennatol 126:356-361. 1992
5. Binderup L: Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Phannacol Toxicol 72:240-244, 1993
6. Binderup L, Carlberg C, Kissmeyer A, Latini S, Mathiasen IS, Mork Hansen C: The need for new vitamin D analogues: mechanisms of action and clinical applica-tions. In: Bouillon R, Norman AW, Thomasset M (eds.). Vitamin D: A Plimpotenl Steroid Hormone: Proceedings of the 9th Workshop on Vitamin D, OrJando, PL, 1994. Walter de Gruyter & Co., Berlin, 1994, pp 55-63
7. Bourke JF, Berth-Jones J, Iqbal SJ, Hutchinson PE: High-dose topical calcipotriol in the treatment of extensive psoriasis vulgaris. BrJ Dennatol 129:74-76, 1993
8. Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker W: Two nuclear signalling pathways for vitamin D. Kalme 361:657-660, 1993
9. dejong EMGJ, van Vlijmen IMMJ, van Erp PEJ, Ramaekers PCS, Troyanovski SM, van de Kerkhof PCM: Keratin 17: a useful marker in anti-psoriasic therapies. Arch Dennatol Res 283:480-482, 1991
10. de Jong EMGJ, van de Kerkhof PCM: Simultaneous assessment of inflammation and epidermal proliferation in psoriatic plaques during long-term treatment with the vitamin Dj analogue MC 903: modulations and interrelations. BrJ Dennatol 124:221-229, 1991
11. De Mare S, dejong EMGJ, van de Kerkhof PCM: DNA content and K.8.12 binding of the psoriatic lesion during treatment with the vitamin D5 analogue MC 903 and betamethasone. BrJ Dermatol 123:291-295, 1990
12. Gardner MJ, Altman DG: Statistics with confidence. Br MeiJ Loud, 1989, p. 37
13. Gown AM, Vogel AM: Monoclonal antibodies to intermediate filament proteins of human cells: unique and cross-reacting antibodies. J Cell Biol 95:414-424, 1982
14. Holland DB, Wood EJ, Roberts SG, West MR, CunliSe WJ: Epidermal keratin levels during oral 1-alpha-hydroxyvitamin D3 treatment for psoriasis. Skin Phannacol 2:68-76, 1989
15. Kragballe K, Gjertsen BT, de Hoop D, Karlsmark T, van de Kerkhof PCM, Larko O, Nieboer C, Roed-Petersen J, Strand A, Tikjob G: Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 337:3-6, 1991
16. Kragballe K, Wildfang IL: Calcipotriol (MC 903), a novel vitamin D3 analogue stimulates terminal differentiation and inhibits proliferation of cultured human keratinocytes. Arch Dennatol Res 282:164-167, 1990
17. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
18. Lane EB, Dartek J, Purkis PE, Leigh IM: Keratin antigens in differentiating skin. Ann N Y Acad Sei 455:241-258, 1985
19. Liao J, Ozono K, McDonnell DP, Pike JW: Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proc Natl Acad SciUSA 87:9751-9755, 1990
20. MacDonald PN, Dowd DR, Haussler MR: New insight into the structure and functions of the vitamin D receptor. Semin Nephrol 14:101-118, 1994
21. Milde P, Hauser U, Simon T, Mall G, Ernst V, Haussler MR, Frosch P, Rauterberg EW: Expression of 1,25-dihydroxyvitamin D3 receptors in normal and psoriatic skin. J Invest Dennatol 97:230-239, 1991
22. Minghetti PP. Norman AW: l,25(OH)2-Vitamin D3 receptors: gene regulation and genetic circuitry. FASEBJ 2:3043-3053, 1988
23. Moll R, Franke WW, Schiller DL: The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24, 1982
24. Morrison NA, Shine J, Fragonas JC, Verkest V, McMenemy ML, Eisman JA: 1,25-dihydroxyvitamül D-responsive element and glycocorticoid repression in the osteocalcin gene. Science 246:1158-1161, 1989
25. Murdoch D, Clissold SP: Calcipotriol. A review of its pharmacological properties and therapeutic use in psoriasis vulgaris. Drug Evaluation 43:415-429, 1992
26. Mork Hansen C, Frandsen TL, Brünner N, Binderup L: lot,25-dihydroxyvitamin D3 inhibits the invasive potential of human breast cancer cells in vitro. Clin Exp Metastasis 12:195-202, 1994
27. Nagle RB: A review of intermediate filament biology and their use in pathologic diagnosis. AW Biol Rep 19:3-21, 1994
28. Ozono K, Liao J, Kerner SA, Scott RA, Pike JW: The vitamin D-responsive element in the human osteocalcin gene. J Dial Cliem 265:21881-21888, 1990
29. Peehl DM, Showronski RJ, Leung GK, Wong ST, Stamey TA, Feldman D: Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic Cells. Cancer Res 54:805-810, 1994
30. Pike JW: Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr 11:189-216, 1991
31. Pothier F, Quellet M, Julien J, Guérin SL: An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells. D\'A Cell Dial 11:83-90, 1992
32. Régnier M, Darmon M: 1,25-dihydroxyvitamin D3 stimulates specifically the last steps of epidermal differentiation of cultured human keratinocytes. Di/erentiation 47:173-188, 1991
33. Reichrath J, Hügel U. Klaus G, Fusenig NE, Rauterberg EW: Modulation of 1,25-dihydroxyvitamin D3 receptor (VDR) expression in Hacat keratinocytes. In: Bouillon R, Norman AW, Thomasset M (eds.). Vitamin D: Gene Regulation, Strttctitre-Fiinction Analysis and Clinical Application. Walter de Gruyter &: Co, Berlin. 1991, pp 445-446
34. Ryle CM, Breitkreutz D, Stark H, Leigh IM, Steinen P, Roop D, Fusenig NE: Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in rJ5-transfected tumorigenic clones. Differentiation 40:42-54, 1989
35. SAS Institute Inc.: SAS/Stat User's Guide, version 6. 4th ed., v. 2. Cary, NC, 1989, pp. 86
36. Schräder M, Müller KM, Carlberg C: Specificity and flexibility of vitamin D signalling. J Biol Chem 269:5501-5504, 1994
37. Towbin H, Staehlin T, Gordon J: Electroforetic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl AcaJ Sei USA 76:4350-4354, 1979