Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo

Human Gene Therapy

Volumn 11, Issue 2, 2000, Pages 305-321

  Kim, Jong J ^a,b   Yang, Joo Sung ^a   Lee, Daniel J ^a   Wilson, Darren M ^a   Nottingham, Liesl K ^a   Morrison, Lake ^a   Tsai, Anthony ^a   Oh, Jim ^a   Dang, Kesen ^a   Dentchev, Tzvete ^a   Agadjanyan, Michael G ^a   Sin, Jeong I ^a   Chalian, Ara A ^a   Weiner, David B ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COLONY STIMULATING FACTOR 1; GLYCOPROTEIN P 15095; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; GENE CASSETTE; GENE TARGETING; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; T LYMPHOCYTE ACTIVATION; VACCINATION;

ANIMALS; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CC; CYTOMEGALOVIRUS; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; GENETIC VECTORS; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HIV-1; HUMANS; INTERLEUKIN-12; INTERLEUKIN-4; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED BALB C; MUSCLES; PLASMIDS; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0034688270     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340050016049     Document Type: Article

References (43)

1. AGADJANYAN, M.G., TRIVEDI, N.N., KUDCHODKAR, S., BENNETT, M., LEVINE, W., LIN, A., BOYER, J., LEVY, D., UGEN, K., KIM, J.J., and WEINER, D.B. (1997). An HIV-2 DNA vaccine induces cross reactive immune responses against HIV-2 and SIV. AIDS Hum. Retroviruses 13, 1561-1572.
2. AGADJANYAN, M.G., KIM, J.J., TRIVEDI, N., WILSON, D.M., MONZAVI-KARBASSI, B., MORRISON, L.D., NOTTINGHAM, L.K., DENTCHEV, T., TSAI, A., DANG, K., CHALIAN, A.A., MALDONADO, M.A., WILLIAMS, W.V., and WEINER, D.B. (1999). CD86 (B7-2) can function to drive MHC-restricted antigen-specific cytotoxic T lymphocyte responses in vivo. J. Immunol. 162, 3417-3427.
3. ALKHATIB, G., COMBADIERE, C., BODER, C.C., FENG, Y., KENNEDY, P.E., MURPHY, P.M., and BERGER E.A. (1996). CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958.
4. BOYER, J.D., UGEN, K.E., WANG, B., AGADJANYAN, M.G., GILBERT, L., BAGARAZZI, M., CHATTERGOON, M., FROST, P., JAVADIAN, A., WILLIAMS, W.V., REFAELI, Y., CICCARELLI, R.B., MCCALLUS, D., CONEY, L., and WEINER, D.B. (1997). Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature Med. 3, 526-532.
5. CARR, M.W., ROTH, S.J., LUTHER, E., ROSE, S.S., and SPRINGER, T.A. (1994). Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. U.S.A. 91, 3652-3656.
6. CASARES, S., INABA, K., BRUMEANU, T.D., STEINMAN, R.M., and BONA, C.A. (1997). Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J. Exp. Med. 186, 1481-1486.
7. CHATTERGOON, M.A., ROBINSON, T.A., BOYER, J.D., and WEINER, D.B. (1998). Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages. J. Immunol. 160, 5707-5718.
8. CHOE, H., FARZAN, M., SUN, Y., SULLIVAN, N., ROLLINS, B., PONATH, P.D., WU, L., MACKAY, C.R., LAROSA, G., NEWMAN, W., GERARD, N., GERARD, C., and SODROSKI, J. (1996). The β-chemokine receptor CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148.
9. CHOW, Y.-H., HUANG, W.-L., CHI, W.-K., CHU, Y.-D., and TAO, M.-H. (1997). Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J. Virol. 71, 169-178.
10. + T cells. Science 270, 1811-1815.
11. COFFMAN, R.L., SEYMOUR, B.W.P., LEBMAN, D.A., HIRAKI, D.D., CHRISTIANSEN, J.A., SHRADER, B., CHERWINSKI, H.M., SAVELKOUL, H.F.J., FINKELMAN, F.D., BOND, M.W., and MOSMANN, T.R. (1988). The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102, 5-28.
12. CONRY, R.M., WIDERA, G., LOBUGLIO, A.F., FULLER, J.T., MOORE, S.E., BARLOW, D.L., TURNER, J., YANG, N.-S., and CURIEL, D.T. (1996). Selected strategies to augment polynucleotide immunization. Gene Ther. 3, 67-74.
13. DAVIS, H.L., MICHEL, M.L., and WHALEN, R.G. (1993). DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol Genet. 2, 1847-1851.
14. DENG, H.K., LIU, R., ELLEMEIER, W., CHOE, S., UNUTMAZ, D., BURKHART, M., DI MARZIO, P., MARMON, S., SUTTON, R.E., HILL, C.M., DAVIS, C.B., PEIPER, S.C., SCHALL, T.J., LITTMAN, D.R., and LANDAU, N.R. (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature (London) 381, 661-666.
15. DORANZ, B.J., RUCKER, J., YI, Y., SMYTH, R.J., SAMSON, M., PEIPER, S.C., PARMENTIER, M., COLLMAN, R.G., and DOMS, R.W. (1996). A dual-tropic primary HIV-1 isolate that uses fusin and the b-chemokine receptros CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85, 1149-1158.
16. DRAGIC, T., LITVIN, V., ALLAWAY, G.P., MARTIN, S.R., HUANG, Y.X., NAGASHIMA, K.A., CAYANAN, C., MADDON, P.J., KOUP, R.A., MOORE, J.P., and PAXTON, W.A. (1996). HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature (London) 381, 667-673.
17. FINKELMAN, F.D., HOLMES, J., KATONA, I.M., URBAN, J.F., BECKMANN, M.P., PARK, L.S., SCHOOLEY, K.A., COFFMAN, R.L., MOSMANN, T.R., and PAUL, W.E. (1990). Lymphokine control of in vivo immunoplobulin isotype selection. Annu. Rev. Immunol. 8, 303-333.
18. IWASAKI, A., STIERNHOLM, B.J., CHAN, A.K., BERSTEIN, N.L., and BARBER, B.H. (1997). Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J. Immunol. 158, 4591-4601.
19. KIM, J.J., and WEINER, D.B. (1997). DNA/genetic vaccination for HIV. Springer Semin. Immunopathol. 19, 174-195.
20. KIM, J.J., BAGARAZZI, M.L., TRIVEDI, N., HU, Y., CHATTERGOON, M.A., DANG, K., MAHALINGAM, S., AGADJANYAN, M.G., BOYER, J.D., WANG, B., and WEINER, D.B. (1997a). Engineering of in vivo immune responses to DNA immunization via co-delivery of costimulatory molecule genes. Nature Biotechnol. 15, 641-645.
21. KIM, J.J., AYYVOO, V., BAGARAZZI, M.L., CHATTERGOON, M.A., DANG, K., WANG, B., BOYER, J.D., and WEINER, D.B. (1997b). In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158, 816-826.
22. KIM, J.J., NOTTINGHAM, L.K., SIN, J.I., TSAI, A., MORRISON, L., OH, J., DANG, K., HU, Y., KAZAHAYA, K., BENNETT, M., DENTCHEV, T., WILSON, D.M., CHALIAN, A.A., BOYER, J.D., AGADJANYAN, M.G., and WEINER, D.B. (1998a). CD8 positive T cells controls antigen-specific immune responses through the expression of chemokines. J. Clin. Invest. 102, 1112-1124.
23. KIM, J.J., TRIVEDI, N.N., NOTTINGHAM, L., MORRISON, L., TSAI, A., HU, Y., MAHALINGAM, S., DANG, K., AHN, L., DOYLE, N.K., WILSON, D.M., CHATTERGOON, M.A., CHALIAN, A.A., BOYER, J.D., AGADJANYAN, M.G., and WEINER, D.B. (1998b). Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur. J. Immunol. 28, 1089-1103.
24. KIM, J.J., TRIVEDI, N.N., WILSON, D.M., MAHALINGAM, S., MORRISON, L., TSAI, A., CHATTERGOON, M.A., DANG, K., PATEL, M., AHN, L., CHALIAN, A.A., BOYER, J.D., KIEBEREMMONS, T., AGADJANYAN, M.G., and WEINER, D.B. (1998c). Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine. Oncogene 17, 3125-3135.
25. LEVY, J.A. (1994). HIV and the Pathogenesis of AIDS. (ASM Press, Washington, D.C.).
26. MACGREGOR, R.R., BOYER, J.D., UGEN, K.E., LACY, K., GLUCKMAN, S., BAGARAZZI, M.L., CHATTERGOON, M., BAINE, Y., HIGGINS, T.J., CICCARELLI, R.B., CONEY, L.R., GINSBERG, R.S., and WEINER, D.B. (1998). First human trial of a facilitated DNA plasmid vaccine for HIV-1 : Safety and host response. J. Infect. Dis. 178, 92-100.
27. MOGENSEN, S.C., and VIRELIZIER, J.L. (1987). The interferon-macrophage alliance. Interferon 8, 55-84. [Review]
28. MOORE, M.A.S. (1991). The clinical use of colony stimulating factors. Annu. Rev. Immunol. 9, 159.
29. PALIARD, X., DE WAAL MALEFIJT, R., YSSEL, H., BLANCHARD, D., CHRETIEN, I., ABRAMS, J., DE VRIES, J., and SPITS, H. (1988). Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J. Immunol. 141, 849-855.
30. RIESER, C., RAMONER, R., BOCK, G., DEO, Y.M., HOLTL, L., BARTSCH, G., and THURNHER, M. (1998). Human monocyte-derived dendritic cells produce macrophage colony-stimulating factor: Enhancement of c-fms expression by interleukin-10. Eur. J. Immunol. 28, 2283-2288.
31. SEDER, R.A., and PAUL, W.E. (1994). Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12, 635-673.
32. SHERR, C. (1990). Colony-stimulating factor-1 receptor. Blood 75, 1-12.
33. SHIRAI, M., PENDLETON, C.D., and BERZOFSKY, J.A. (1992). Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules. J. Immunol. 148, 1657-1667.
34. SIN, J.I., KIM, J.J., UGEN, K.E., CICCARELLI, R.B., HIGGINS, T.J., and WEINER, D.B. (1998). Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte macrophage-colony stimulating factor expression cassettes. Eur. J. Immunol. 28, 3530-3540.
35. TAKAHASHI, H., NAKAGAWA, Y., PENDLETON, C.D., HOUGHTEN, R.A., YOKOMURO, K., GERMAIN, R.N., and BERZOFSKY, J.A. (1992). Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science 255, 333-336.
36. TANG, D., DEVIT, M., and JOHNSTON, S. (1992). Genetic immunization is a simple method for eliciting an immune response. Nature (London) 356, 152-154.
37. TASCON, R.E., COLSTON, M.J., RAGNO, S., STAVROPOULOS, E., GREGORY, D., and LOWRIE, D.B. (1996). Vaccination against tuberculosis by DNA injection. Nature Med. 2, 888-892.
38. TSUJI, T., HAMAJIMA, K., ISHII, N., AOKI, I., FUKUSHIMA, J., XIN, K.Q., KAWAMOTO, S., SASAKI, S., MATSUNAGA, K., ISHIGATSUBO, Y., TANI, K., OKUBO, T., and OKUDA, K. (1997). Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen. Eur. J. Immunol. 27, 782-787.
39. ULMER, J.B., DONNELLY, J., PARKER, S.E., RHODES, G.H., FELGNER, P.L., DWARKI, V.L., GROMKOWSKI, S.H., DECK, R., DEVITT, C.M., FRIEDMAN, A., HAWE, L.A., LEANDER, K.R., MARINEZ, D., PERRY, H., SHIVER, J.W., MONTGOMERY, D., and LIU, M.A. (1993). Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1749.
40. WANG, B., UGEN, K.E., SRIKANTAN, V., AGADJANYAN, M.G., DANG, K., REFAELI, Y., SATO, A., BOYER, J., WILLIAMS, W.V., and WEINER, D.B. (1993). Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U.S.A. 90, 4156-4160.
41. WANG, R., DOOLAN, D.L., LE, T.P., HEDSTROM, R.C., COONAN, K.M., CHAROENVIT, Y., JONES, T.R., HOBART, P., MARGALITH, M., NG, J., WEISS, W.R., SEDEGAH, M., DE TAISNE, C., NORMAN, J.A., and HOFFMAN, S.L. (1998). Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282, 476-480.
42. WOLFF, J.A., MALONE, R.W., WILLIAMS, P., CHONG, W., ACSADI, G., JANI, A., and FELGNER, P.L. (1990). Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468.
43. XIANG, Z., and ERTL, H.C. (1995). Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2, 129-135.