Hunting the emesis and efficacy targets of PDE4 inhibitors: Identification of the photoaffinity probe 8-(3-azidophenyl)-6-[(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ) [2]

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3820-3823

  Macdonald, D ^a   Perrier, H ^a   Liu, S ^a   Laliberte, F ^a   Rasori, R ^a   Robichaud, A ^a   Masson, P ^a   Huang, Z ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 (3 AZIDOPHENYL) 6 [(4 IODO 1H 1 IMIDAZOLYL)METHYL]QUINOLINE; KF 18280; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; QUINOLINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FERRET; LETTER; NONHUMAN; PHOTOAFFINITY LABELING; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTI-ASTHMATIC AGENTS; AZIDES; BRONCHOCONSTRICTION; CELL LINE; ENZYME INHIBITORS; FERRETS; GUINEA PIGS; HUMANS; PHOTOAFFINITY LABELS; QUINOLINES; RECOMBINANT FUSION PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VOMITING;

EID: 0034687225     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000065c     Document Type: Letter

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