Synthesis and Biological Evaluation of Integrin Antagonists Containing trans- and cis-2,5-Disubstituted THF Rings

Chemistry - A European Journal

Volumn 6, Issue 4, 2000, Pages 666-683

  Osterkamp, Frank ^a   Ziemer, Burkhard ^a   Koert, Ulrich ^a   Wiesner, Matthias ^b   Raddatz, Peter ^b   Goodman, Simon L ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Integrin antagonists; Peptidomimetics; Synthesis design; turn

Indexed keywords

ANTINEOPLASTIC AGENT; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; FIBRINOGEN RECEPTOR; FRADAFIBAN; FURAN DERIVATIVE; GANTOFIBAN; INTEGRIN; INTEGRIN RECEPTOR; INTEGRIN RECEPTOR ANTAGONIST; OLIGOPEPTIDE; RECEPTOR BLOCKING AGENT; SB 223245; SIBRAFIBAN; TETRAHYDROFURAN; TIROFIBAN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; XEMILOFIBAN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HUMAN; IC 50; METABOLISM; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; RECEPTOR BLOCKING; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; EVALUATION STUDIES; FURANS; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RECEPTORS, VITRONECTIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034681464     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3765(20000218)6:4<666::AID-CHEM666>3.0.CO;2-Z     Document Type: Article

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