A convenient synthesis of di-(benzyloxycarbonyl)-protected guanidines

Synthetic Communications

Volumn 26, Issue 2, 1996, Pages 407-413

  Su, Weiguo ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030029844     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919608003629     Document Type: Article

References (16)

1. Guanidines: Historical, Biological, Biochemical, and Clinical Aspects of the Naturally Occurring Guanidino Compounds; Mori, A.; Cohen, B. D.; Lowenthal, A., Eds.; Plenum: New York, 1983.
2. Oilman, A. G.; Goodman, L. S. and Gilman, A., Eds., The Pharmacological Basis of Therapeutics, 6th Edition, p 180, Macmillan Co., New York, 1980.
3. (a). McKay, A. F. and Kreling, M.-E., Can. J. Chem., 35, 1438 (1957);
4. (b). Schmidtchen, F. P., Chem. Ber., 113, 2175 (1980).
5. (a). Barton, D. H. R.; Elliot, J. D. and Géro, S. D., Chem. Comm., 1136 (1981);
6. (b). Barton, D. H. R.; Elliot, J. D. and Géro, S. D., J. Chem. Soc. Perkin Trans. 1, 2085 (1982).
7. Yamamoto, Y.; Kojima, S., "The Chemistry of Amidines and Imidates", Patai, S. and Rappoport, Z., Ed., John Wiley & Sons, New York, 1991; Vol. 2, Chapter 10.
8. Atwal, K. S.; Ahmed, S. Z. and O'Reilly, B. C., Tetrahedron Letters, 30, 7313 (1989).
9. Kim, K. S. and Qian, L., Tetrahedron Letters, 34, 7677 (1993).
10. Dodd, D. S. and Kozikowski, A. P., Tetrahedron Letters, 35, 977 (1994).
11. Drake, B.; Patek, M. and Lebl, M., Synthesis, 579 (1994).
12. Iwanowicz, E. J.; Poss, M. A. and Lin, J., Synth. Comm., 23, 1443 (1993).
13. Tian, Z.; Edwards, P. and Roeske, R. W., Int. J. Peptide Protein Res., 40, 119 (1992).
14. 2O, Calc'd: C 67.80, H 7.44, N 9.12; Found: C 67.71, H 7.24, N 9.18.
15. 3): (m/z) 432 (M+1).
16. 3): (m/z) 164 (M+1).