A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development

Current Biology

Volumn 10, Issue 22, 2000, Pages 1427-1437

  Wilkins, Andrew ^a   Chubb, Jonathan R ^a,c   Insall, Robert H ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CELL FUNCTION; CELL GROWTH; DISCOIDIN; FRUITING BODY; GENE DISRUPTION; GENE IDENTIFICATION; GENETIC REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HOMOLOGY; PINOCYTOSIS; RAS PROTEIN; SOS PROTEIN;

DICTYOSTELIUM; EUKARYOTA; SACCHAROMYCES;

EID: 0034676278     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00797-1     Document Type: Article

References (51)

1. The ras superfamily
2. Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
3. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
4. Ras pathways in Caenorhabditis elegans
5. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
6. A role for the Ras signalling pathway in synaptic transmission and long-term memory
7. Ras versus cyclin-dependent kinase inhibitors
8. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins
9. Dictyostelium RasG is required for normal motility and cytokinesis, but not growth
10. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
11. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe
12. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
13. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
14. Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
15. Identification of murine homologues of the Drosophila son of sevenless gene: Potential activators of ras
16. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
17. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
18. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
19. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP
20. Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum
21. Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily
22. A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes
23. Growing and developing Dictyostelium cells express different ras genes
24. Dictyostelium RasD is required for normal phototaxis, but not differentiation
25. The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement
26. The Dictyostelium developmental cDNA project: Generation and analysis of expressed sequence tags from the first-finger stage of development
27. Fluid-phase uptake by macropinocytosis in Dictyostelium
28. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G-protein β-subunits
29. Changes on the cell surface and of the digestive apparatus of Dictyostelium discoideum during the starvation period triggering aggregation
30. Microbiological assay for cyclic 3′,5′-AMP
31. Regulation of the discoidinlγ-gene in Dictyostelium discoideum - Identification of individual promoter elements mediating induction of transcription and repression by cyclic AMP
32. Complete sequence and transcript regulation of a cell adhesion protein from aggregating Dictyostelium cells
33. Phagocytosis and exocytosis by differentiating Dictyostelium discoideum cells
34. The developmental regulation of single-cell motility in Dictyostelium discoideum
35. PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium
36. The catalytic domain of the mouse sos1 gene product activates Ras proteins in vivo and in vitro
37. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator
38. Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
39. Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras
40. Proteins regulating Ras and its relatives
41. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
42. 32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution end impairs pinocytosis
43. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
44. Coronin involved in phagocytosis: Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag
45. The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase
46. Identification of darlin, a Dictyostelium protein with armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells
47. Discoidin proteins of Dictyostelium are necessary for normal cytoskeletal organization and cellular morphology during aggregationl
48. A transformation vector for Dictyostelium discoideum with a new selectable marker Bsr
49. Cloning vectors for the production of proteins in Dictyostelium discoideum
50. Redundancy in the microfilament system - Abnormal development of Dictyostelium cells lacking two F-actin cross-linking proteins
51. Transformation of S. cerevisiae by the lithium acetate/single stranded carrier DNA/PEG (LiAc/ss-DNA/PEG) protocol