Dictyostelium RasD is required for normal phototaxis, but not differentiation

Genes and Development

Volumn 14, Issue 11, 2000, Pages 1407-1413

  Wilkins, Andrew ^a   Khosla, Meenal ^b   Fraser, Derek J ^c   Spiegelman, George B ^b   Fisher, Paul R ^c   Weeks, Gerald ^b   Insall, Robert H ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c LA TROBE UNIVERSITY   (Australia)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Dictyostelium; Oncogenes; Phototaxis; Ras; Small GTPases

Indexed keywords

PROTOZOAL PROTEIN; RAS PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL MOTION; CONTROLLED STUDY; DICTYOSTELIUM; GENE DISRUPTION; NONHUMAN; PHOTOTAXIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN ISOLATION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL DIVISION; DICTYOSTELIUM; LIGHT; MOVEMENT; MUTAGENESIS; PHOTOSYNTHESIS; RAS PROTEINS; SIGNAL TRANSDUCTION; TEMPERATURE; TRANSFECTION;

EID: 0034214181     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Berks, M. and R.R. Kay. 1990. Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum. Development 110: 977-984.
2. Bourne, H.R., D.A. Sanders, and F. McCormick. 1990. The GT-Pase superfamily: A conserved switch for diverse cell functions. Nature 348: 125-132.
3. Chubb, J.R., A. Wilkins, G. Thomas, and R.H. Insall. 2000. The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement. J. Cell Sci. 113: 709-719.
4. Daniel, J., G.B. Spiegelman, and G. Weeks. 1993. Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum. Oncogene 8: 1041-1047.
5. Daniel, J., J. Bush, J. Cardelli, G.B. Spiegelman, and G. Weeks. 1994. Isolation of two novel ras genes in Dictyostelium discoideum - evidence for a complex, developmentally regulated ras gene subfamily. Oncogene 9: 501-508.
6. Darcy, P.K., Z. Wilczynska, and P.R. Fisher. 1994. Genetic analysis of Dictyostelium slug phototaxis mutants. Genetics 137: 977-985.
7. Dingermann, T., N. Reindl, H. Werner, M. Hildebrandt, W. Nellen, A. Harwood, J. Williams, and K. Nerke. 1989. Optimization and in situ detection of Escherichia coli β-galactosidase gene expression in Dictyostelium discoideum. Gene 85: 353-362.
8. Early, A.E., M.J. Gaskell, D. Traynor, and J.G. Williams. 1993. Two distinct populations of prestalk cells within the tip of the migratory Dictyostelium slug with differing fates at culmination. Development 118: 353-362.
9. Esch, R.K. and R.A. Firtel. 1991. cAMP and cell sotting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium. Genes & Dev. 5: 9-21.
10. Esch, R.K., P.K. Howard, and R.A. Firtel. 1992. Regulation of the Dictyostelium cAMP-induced, prestalk-specific DdrasD gene: Identification of cis-acting elements. Nucleic Acids Res. 20: 1325-1332.
11. Fisher, F.R., E. Smith, and K.L. Williams. 1981. An extracellular chemical signal controlling phototactic behavior by D. discoideum slugs. Cell 23: 799-807.
12. Fisher, P.R. 1997. Genetics of phototaxis in a model eukaryote, Dictyostelium discoideum. BioEssays 19: 397-407.
13. Fisher, P.R. and K.L. Williams. 1981. Bidirectional phototaxis by Dictyostelium discoideum slugs. FEMS Microbiol Lett. 12: 87-89.
14. Fisher, P.R., A.A. Noegel, M. Fechheimer, F. Rivero, J. Prassler, and G. Gerisch. 1997. Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the F-actin cross-linking gelation factor (ABP-120). Can. Biol. 7: 889-892.
15. Fortini, M., M. Simon, and G. Rubin. 1992. Signaling by the sevenless protein tyrosine kinase is mimicked by ras1 activation. Nature 355: 559-561.
16. Franke, J. and R. Kessin. 1977. A defined minimal medium for axenic strains of Dictyostelium discoideum. Proc. Natl. Acad. Sci. 74: 2157-2161.
17. Han, M. and P. Sternberg. 1990. Let-60, a gene which specifies cell fates during vulval induction, encodes a ras protein. Cell 63: 921-931.
18. Harwood, A.J., N.A. Hopper, M.N. Simon, S. Bouzid, M. Veron, and J.G. Williams. 1992. Multiple roles for cAMP-dependent protein kinase during Dictyostelium development. Dev. Biol. 149: 90-99.
19. Howard, P.K., K.G. Ahern, and R.A. Firtel. 1988. Establishment of a transient expression system for Dictyostelium discoideum. Nucleic Acids Res. 16: 2613-2623.
20. Insall, R.H., J. Borleis, and P.N. Devreotes. 1996. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr. Biol. 6: 719-729.
21. Jermyn, K.A., M. Berks, R.R. Kay, and J.G. Williams. 1987. Two distinct classes of prestalk-enriched mRNA sequences in Dictyostelium discoideum. Development 100: 745-755.
22. Khosla, M., S.M. Robbins, G.B. Spiegelman, and G. Weeks. 1990. Regulation of DdrasG gene expression during Dictyostelium development. Mol. Cell. Biol. 10: 918-922.
23. Khosla, M., G.B. Spiegelman, G. Weeks, T.W. Sands, K.J. Virdy, and D.A. Cotter. 1994. RasG protein accumulation occurs just prior to amoebae emergence during spore germination in Dictyostelium discoideum. FEMS Microbiol. Lett. 117: 293-298.
24. Khosla, M., G.B. Spiegelman, and G. Weeks. 1996. Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development. Mol. Cell. Biol. 16: 4156-4162.
25. Louis, S.A., G.B. Spiegelman, and G. Weeks. 1997. Expression of an activated rasD gene changes cell fate decisions during Dictyostelium development. Mol. Biol. Cell 8: 303-312.
26. Mulcahy, L.S., M.R. Smith, and D.W. Stacey. 1985. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 313: 241-243.
27. Reymond, C.D., R.H. Gomer, M.C. Mehdy, and R.A. Firtel. 1984. Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian Ras protein. Cell 39: 141-148.
28. Reymond, C.D., R.H. Gomer, W. Nellen, A. Theibert, P. Devreotes, and R. Firtel. 1986. Phenotypic changes induced by a mutated Ras gene during the development of Dictyostelium transformants. Nature 323: 340-343.
29. Robbins, S.M., J.G. Williams, K.A. Jermyn, G.B. Spiegelman, and G. Weeks. 1989. Growing and developing Dictyostelium cells express different ras genes. Proc. Natl. Acad. Sci. 86: 938-942.
30. Shih, T., M. Weeks, H. Young, and E. Scolnick. 1979. Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus. Virology 96: 64-79.
31. Smith, E., P.R. Fisher, W.N. Grant, and K.L. Williams. 1982. Sensory behaviour in Dictyostelium discoideum slugs: Phototaxis and thermotaxis are not mediated by a change in slug speed. J. Cell Sci. 54: 329-339.
32. Sorcher, S., A. Schonthal, A. Alberts, J. Meinkoth, and J. Feramisco. 1993. The ras superfamily of GTPases. In The ras superfamily of GTPases (ed. J. Lacal and F. McCormick), pp. 85-101. CRC Press, Boca Raton, FL.
33. Sun, T.J., P.J.M. Van Haastert, and P.N. Devreotes. 1990. Surface cAMP receptors mediate multiple responses during development in Dictyostelium - evidenced by antisense mutagenesis. J. Cell Biol. 110: 1549-1554.
34. Sussman, R. and M. Sussman. 1967. Cultivation of Dictyostelium discoideum in axenic culture. Biochem. Biophys. Res. Commun. 29: 53-55.
35. Sutoh, K. 1993. A transformation vector for Dictyostelium discoideum with a new selectable marker Bsr. Plasmid 30: 150-154.
36. Toda, T., I. Uno, T. Ishikawa, S. Powers, T. Kataoka, D. Broek, S. Cameron, J. Broach, K. Matsumoto, and M. Wigler. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40: 27-36.
37. Tuxworth, R.I., J.L. Cheetham, L.M. Machesky, G.B. Spiegelmann, G. Weeks, and R.H. Insall. 1997. Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. J. Cell Biol. 138: 605-614.
38. Valencia, A. and C. Sander. 1995. The ras superfamily. In Guidebook to the small GTPases (ed. M. Zerial and L. Huber), pp. 12-19. Oxford University Press, Oxford, UK.
39. Van Haastert, P.J.M., F. Kesbeke, C.D. Reymond, R. Firtel, E. Luderus, and R. Van Driel. 1987. Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene. Proc. Natl. Acad. Sci. 84: 4905-4909.