Immunodominance in the CTL response against minor histocompatibility antigens: Interference between responding T cells, rather than with presentation of epitopes

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 4499-4505

  Wolpert, Elisabeth Z ^a   Grufman, Per ^a   Sandberg, Johan K ^a   Tegnesjö, Anna ^a   Kärre, Klas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; EPITOPE; MINOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIGEN PRESENTATION; BONE MARROW CELLS; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; IMMUNIZATION; IMMUNODOMINANT EPITOPES; MICE; MICE, CONGENIC; MICE, INBRED BALB C; MICE, INBRED C57BL; MINOR HISTOCOMPATIBILITY ANTIGENS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032211137     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Adorini, L., E. Appella, G. Doria, and Z.A. Nagy. 1988. Mechanisms influencing the immunodominance of T cell determinants. J. Exp. Med. 168:2091.
2. Berzofsky, J.A. 1988. Immunodominance in T lymphocyte recognition. Immunol. Lett. 18:83.
3. Sercarz, E. E., P. V. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:729.
4. Barber, L. D., and P. Parham. 1994. The essence of epitopes. J. Exp. Med. 180:1191.
5. Fairchild, P. J., and D. C. Wraith. 1996. Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC. Immunol. Today 17:80.
6. Vijh, S., and E. G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158:3366.
7. b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen. J. Virol. 69:6665.
8. b-restricted epitopes. J. Immunol. 157:5555.
9. Oukka, M., J. C. Manuguerra, N. Livaditis, S. Tourdot, N. Riche, I. Vergnon, P. Cordopatis, and K. Kosmatopoulos. 1996. Protection against lethal viral infection by vaccination with nonimmunodominant peptides. J. Immunol. 157:3039.
10. Deng, Y., J. W. Yewdell, L. C. Eisenlohr, and J. R. Bennink. 1997. MHC affinity, peptide liberation. T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J. Immunol. 158:1507.
11. Wettstein, P. J., and D. W. Bailey. 1982. Immunodominance in the immune response to "multiple" histocompatibility antigens, Immunogenetics 16:47.
12. Korngold, R., and P. J. Wettstein. 1990. Immunodominance in the graft-vs-host disease T cell response to minor histocompatibility antigens. J. Immunol. 145: 4079.
13. Franksson, L., M. Petersson, R. Kiessling, and K. Kärre. 1993. Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells. Eur. J. Immunol. 23:2606.
14. Yin, L., G. Poirier, O. Neth, J. J. Hsuan, N. F. Totty, and H. J. Stauss. 1993. Few peptides dominate cytotoxic T lymphocyte responses to single and multiple minor histocompatibility antigens. Int. Immunol. 5:1003.
15. Wolpert, E., L. Franksson, and K. Kärre. 1995. Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides. Int. Immunol. 7:919.
16. Goulmy, E., R. Schipper, J. Pool, E. Blokland, J. H. Falkenburg, J. Vossen, A. Grathwohl, G. B. Vogelsang, H. C. van Houwelingen, and J. J. van Rood. 1996. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N. Engl. J. Med. 334:281.
17. Chen, W., S. Khilko, J. Fecondo, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by non-dominant anchor residues. J. Exp. Med. 180:1471.
18. Dick, L. R., C. Aldrich, S. C. Jameson, C. R. Moomaw, B. C. Pramanik, C. K. Doyle, G. N. DeMartino, M. J. Bevan, J. M. Forman, and C. A. Slaughter. 1994. Proteolytic processing of ovalbumin and β-galactosidase by the proteasome to a yield antigenic peptides. J. Immmol. 152:3804.
19. Niedermann, G., G. King, S. Butz, U. Birsner, R. Grimm, J. Shabanowitz, D. F. Hunt, and K. Eichmann. 1996. The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides. Proc. Natl. Acad. Sci. USA 93:8572.
20. Eggers, M., B. Boes-Fabian, T. Ruppert, P. M. Kloetzel, and U. H. Koszinowski. 1995. The cleavage preference of the proteasome governs the yield of antigenic peptides. J. Exp. Med. 182:1865.
21. Heemels, M. T., and H. Ploegh. 1995. Generation, translocation, and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 64:463.
22. Sette, A., A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. M. Kast, C. J. Melief, C. Oseroff, L. Yuan, and J. Ruppert. 1994. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J. Immunol. 153:5586.
23. van der Most, R. G., A. Sette, C. Oseroff, J. Alexander, K. Murali-Krishna, L. L. Lau, S. Southwood, J. Sidney, R. W. Chesnut, M. Matloubian, et al. 1996. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 157:5543.
24. Levitsky, V., Q. Zhang, J. Levitskaya, M. G. Kurilla, and M. G. Masucci. 1997. Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from MHC class I:peptide complexes. J. Immunol. 159:5383.
25. van der Burg, S. H., M. J. Visseren, R. M. Brandt, W. M. Kast, and C. J. Melief. 1996. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol. 156:3308.
26. Levitsky, V., Q. J. Zhang, J. Levitskaya, and M. G. Masucci. 1996. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 183: 915.
27. Matsui, K., J. J. Boniface, P. Steffner, P. A. Reay, and M. M. Davis. 1994. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91:12862.
28. Campos-Lima, P. O., V. Levitsky, M. P. Imreh, R. Gavioli, and M. G. Masucci. 1997. Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 186:83.
29. - strains. Proc. Natl. Acad. Sci. USA 91:11482.
30. Daly, K., P. Nguyen, D. L. Woodland, and M. A. Blackman. 1995. Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire. J. Virol. 69:7416.
31. + CTL response to an influenza hemagglutinin epitope reflects limited T cell availability. J. Immunol. 157:505.
32. Bailey, D. W., and L. E. Mobraaten. 1969. Estimates of the number of loci contributing to the histoincompatibility between C57BL/6 and BALB/c strains of mice. Transplantation 7:394.
33. Goulmy, E., J. W. Gratama, E. Blokland, F. E. Zwaan, and J. J. van Rood. 1983. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease. Nature 302:159.
34. Loveland, B., and E. Simpson. 1986. The non-MHC transplantation antigens: neither weak nor minor. Immunol. Today 7:223.
35. Goulmy, E. 1996. Human minor histocompatibility antigens. Curr. Opin. Immunol. 8:75.
36. Wallny, H. J., and H. G. Rammensee. 1990. Identification of classical minor histocompatibility antigen as cell-derived peptide. Nature 343:275.
37. Loveland, B., C. R. Wang, H. Yonekawa, E. Hermel, and K. F. Lindahl. 1990. Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein. Cell 60:971.
38. den Haan, J. M., N. E. Sherman, E. Blokland, E. Huczko, F. Koning, J. W. Drijfhout, J. Skipper, J. Shabanowitz, D. F. Hunt, and V. H. Engelhard. 1995. Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science 268:1476.
39. den Haan, J. M., R. E. Bontrop, J. Pool, N. Sherman, E. Blokland, V. H. Engelhard, D. F. Hunt, and E. Goulmy. 1996. Conservation of minor histocompatibility antigens between human and non-human primates. Eur. J. Immunol. 26:2680.
40. Greenfield, A., D. Scott, D. Pennisi, I. Ehrmann, P. Ellis, L. Cooper, E. Simpson, and P. Koopman. 1996. An H-Y Db epitope is encoded by a novel mouse Y chromosome gene. Nat. Genet. 14:474.
41. Morse, M. C., G. Bleau, V. M. Dabhi, F. Hetu, E. A. Drobetsky, K. F. Lindahl, and C. Perreault. 1996. The COI mitochondrial gene encodes a minor histocompatibility antigen presented by H2-M3. J. Immunol. 156:3301.
42. Perreault, C., J. Jutras, D. C. Roy, J. G. Filep, and S. Brochu. 1996. Identification of an immunodominant mouse minor histocompalibility antigen (MiHA): T cell response to a single dominant MiHA causes graft-versus-host disease. J. Clin. Invest. 98:622.
43. Meadows, L., W. Wang, J. M. den Haan, E. Blokland, C. Reinhardus, J. W. Drijfhout, J. Shabanowitz, R. Pierce, A. I. Agulnik, C. E. Bishop, et al. 1997. The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6:273.
44. Mendoza, L. M., P. Paz, A. Zuberi, G. Christianson, D. Roopenian, and N. Shastri. 1997. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 7:461.
45. van der Harst, D., E. Goulmy, J. H. Falkenburg, Y. M. Kooij-Winkelaar, S. A. van Luxemburg-Heijs, H. M. Goselink, and A. Brand. 1994. Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones. Blood 83:1060.
46. Pion, S., P. Fontaine, C. Baron, M. Gyger, and C. Perreault. 1995. Immunodominant minor histocompatibility antigens expressed by mouse leukemic cells can serve as effective targets for T cell immunotherapy. J. Clin. Invest. 95:1561.
47. Ressing, M. E., A. Sette, R. M. Brandt, J. Ruppert, P. A. Wentworth, M. Hartman, C. Oseroff, H. M. Grey, C. J. Melief, and W. M. Kast. 1995. Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides. J. Immunol. 154:5934.
48. Kärre, K., H. G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature 319:675.
49. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
50. Wettstein, P. J. 1986. Immunodominance in the T-eell response to multiple non H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens. Immunogenetics 24:24.
51. Wettstein, P. J. 1986. Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. III. Single histocompatibility antigens dominate the male antigen. J. Immunol. 137:2073.
52. Pion, S., P. Fontaine, M. Desaulniers, J. Jutras, J. G. Filep, and C. Perreault. 1997. On the mechanisms of immunodominance in cytotoxic T lymphocyte responses to minor histocompatibility antigens. Eur. J. Immunol. 27:421.
53. b-restricted epitopes and reversal by dendritic cell-mediated antigen delivery. J. Immunol. 160:3163.
54. Crispe, I. N., and T. Owens. 1985. Suppression induction in vivo by a T helper clone? Eur. J. Immunol. 15:407.
55. Eberl, G., B. Kessler, L. P. Eberl, M. J. Brunda, D. Valmori, and G. Corradin. 1996. Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12. Eur. J. Immunol. 26:2709.
56. Mitchison, N. A., and C. O'Malley. 1987. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur. J. Immunol. 17:1579.
57. Saizawa, M., A. Mabuchi, K. Yokomuro, and Y. Kimura. 1987. Antigen-specific T cell cluster formation on antigen-pulsed macrophage monolayers in mice. Microbiol. Immunol. 31:779.
58. Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587.
59. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
60. Scott, B., J. Kaye, and D. Lo. 1994. T cells and suppression in vitro. Science 266:464.
61. De Boer, R. J., and A. S. Perelson. 1994. T cell repertoires and competitive exclusion. J. Theor. Biol. 169:375.
62. + T cells. Eur. J. Immunol. 26:2640.