The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord

Anesthesiology

Volumn 91, Issue 5, 1999, Pages 1401-1407

  Zhang, Chousheng ^b   Davies, M Frances ^b   Guo, Tian Zhi ^b   Maze, Mervyn ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b NONE

Author keywords

Analgesia; Descending; Inhibition; Naltrexone; Nitrous oxide; Norepinephrine

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; ALPHA 2 ADRENERGIC RECEPTOR; NALTREXONE; NITROUS OXIDE; OPIATE RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL TISSUE; ARTICLE; NONHUMAN; NORADRENALIN RELEASE; NORADRENERGIC SYSTEM; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SPINAL CORD DORSAL HORN; SPINAL CORD TRANSSECTION; TAIL FLICK TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; BENZYLAMINES; CHROMATOGRAPHY, ION EXCHANGE; CORDOTOMY; INJECTIONS, SPINAL; MALE; MICRODIALYSIS; NALTREXONE; NARCOTIC ANTAGONISTS; NEUROTRANSMITTER UPTAKE INHIBITORS; NITROUS OXIDE; NOREPINEPHRINE; PAIN MEASUREMENT; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, OPIOID; SPINAL CORD;

EID: 0032746625     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199911000-00033     Document Type: Article

References (42)

1. Guo TZ, Poree L, Golden W, Stein J, Fujinaga M, Maze M: Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat. ANESTHESIOLOGY 1996; 85:846-52
2. Quock RM, Kouchich FJ, Tseng LF: Does nitrous oxide induce release of brain opioid peptides? Pharmacology 1985; 30:95-9
3. Zuniga JR, Joseph SA, Knigge KM: The effects of nitrous oxide on the central endogenous pro-opiomelanocortin system in the rat. Brain Res 1987; 420:57-65
4. Zuniga JR, Joseph SA, Knigge KM: The effects of nitrous oxide on the secretory activity of pro-opiomelanocortin peptides from basal hypothalamic cells attached to cytodex beads in a superfusion in vitro system Brain Res 1987; 420:66-72
5. 7 into canine third ventricular cerebrospinal fluid. Anesth Analg 1995; 80:664-70
6. Yeung JC Yaksh TL, Rudy TA: Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat. Pain 1977; 4:23-40
7. Fang F, Guo TZ, Davies MF, Maze M: Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats. Eur J Pharmacol 1997; 336:137-41
8. Hodges BL, Gagnon MJ, Gillespie TR, Breneisen JR, O'Leary DF, Hara S, Quock RM: Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific mu and epsilon opioid receptor blockade. J Pharmacol Exp Ther 1994; 269:596-600
9. Skilling SR, Smullin DH, Beitz AJ, Larson AA: Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation. J Neurochem 1988; 51:127-32
10. Liu DX, Valadez V, Sorkin LS, McAdoo DJ: Norepinephrine and serotonin release upon impact injury to rat spinal cord. J Neurotrauma 1990; 7:219-27
11. Peng YB, Lin Q, Willis WD: Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats. J Pharmacol Exp Ther 1996; 278:125-35
12. Guo TZ, Jiang JY, Buttermann AE, Maze M: Dexmedetomidine injection into the locus ceruleus produces antinociception. ANESTHESIOLOGY 1996; 84:873-81
13. Berkowitz BA, Finck AD, Ngai SH: Nitrous oxide analgesia: Reversal by naloxone and development of tolerance. J Pharmacol Exp Ther 1977; 203:539-47
14. Theron CN, de Villiers AS, Taljaard JJ: Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration. Neurochem Res 1993; 18:1321-7
15. Karuri AR, Kugel G, Engelking LR, Kumar MS: Alterations in catecholamine turnover in specific regions of the rat brain following acute exposure to nitrous oxide. Brain Res Bull 1998; 45:557-61
16. Murakawa M, Sningu K, Mori K: Effects of nitrous oxide on the brain catecholamines in rats. Ann Acad Med Singapore 1994; 23:452-5
17. Nagasaka H, Taguchi M, Tsuchiya M, Mizumoto Y, Hori K, Hayashi K, Matsumoto I, Hori T, Sato I: Effect of nitrous oxide on spinal dorsal horn WDR neuronal activity in cats [in Japanese]. Masui 1997; 46:1190-6
18. Loughlin SE, Leslie FM, Fallon JH: Endogenous opioid systems, The Rat Nervous System, 2nd edition. Edited by Paxinos G. San Diego, Academic Press, 1995, pp 975-1001
19. Hara S, Gagnon MJ, Quock RM, Shibuya T: Effect of opioid peptide antisera on nitrous oxide antinociception in rats. Pharmacol Biochem Behav 1994; 48:699-702
20. Quock RM, Kouchich FJ, Tseng LF: Influence of nitrous oxide upon regional brain levels of methionine-enkephalin-like immunoreactiviry in rats. Brain Res Bull 1986; 16:321-3
21. Fallon JH, Leslie FM: Distribution of dynorphin and enkephalin peptides in the rat brain. J Comp Neurol 1986; 249:293-336
22. Terenzi MG, Guimaraes FS, Prado WA: Antinociception induced by stimulation of the habenular complex of the rat. Brain Res 1990; 524:213-8
23. Terenzi MG, Prado WA: Antinociception elicited by electrical or chemical stimulation of the rat habenular complex and its sensitivity to systemic antagonists. Brain Res 1990; 535:18-24
24. Wang Q, Mao LM, Han JS: Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats. Exp Brain Res 1990; 80:201-4
25. Oliveira MA, Prado WA: Antinociception induced by stimulating amygdaloid nuclei in rats: Changes produced by systemically administered antagonists. Braz J Med Biol Res 1998; 31:681-90
26. Aimone LD, Jones SL, Gebhart GF: Stimulation-produced descending inhibition from the periaqueductal gray and nucleus raphe magnus in the rat: Mediation by spinal monoamines but not opioids Pain 1987; 31:123-36
27. Jensen TS, Yaksh TL: Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res 1984; 321:287-97
28. Camarata PJ, Yaksh TL: Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Res 1985; 336:133-42
29. Pang IH, Vasko MR: Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception. Brain Res 1986; 371: 171-6
30. Budai D, Harasawa I, Fields HL: Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors. J Neurophysiol 1998; 80:2244-54
31. Westlund KN, Bowker RM, Ziegler MG, Coulter JD: Origins and terminations of descending noradrenergic projections to the spinal cord of monkey. Brain Res 1984; 292:1-16
32. Clark FM, Proudfit HK: The projections of noradrenergic neurons in the A5 catecholamine cell group to the spinal cord in the rat: Anatomical evidence that A5 neurons modulate nociception. Brain Res 1993; 616:200-21
33. Rohde DS, Basbaum AI: Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat. J Neurosci 1998; 18:4393-402
34. Cameron AA, Khan IA, Westlund KN, Willis WD: The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris-leucoagglutinin study: II. Descending projections. J Comp Neurol 1995; 351:585-601
35. Byrum CE, Guyenet PG: Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol 1987; 261: 529-42
36. Ennis M, Behbehani M, Shipley MT, Van Bockstaele EJ, Aston-Jones G: Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: Anatomic and physiologic studies. J Comp Neurol 1991; 306:480-94
37. Bajic D, Proudfit HK: Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J Comp Neurol 1999; 405:359-79
38. Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL: Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett 1996; 209:73-6
39. Ramsay DS, Brown AC, Woods SC: Acute tolerance to nitrous oxide in humans. Pain 1992; 51:367-73
40. Avramov MN, Shingu K, Mori K: Progressive changes in electroencephalographic responses to nitrous oxide in humans: A possible acute drug tolerance. Anesth Analg 1990; 70:369-74
41. Rupreht J, Dworacek B, Bonke B, Dzoljic MR, van Eijndhoven JH, de Vlieger M: Tolerance to nitrous oxide in volunteers. Acta Anaesthesiol Scand 1985; 29:635-8
42. Ngai SH, Finck AD: Prolonged exposure to nitrous oxide decreased opiate receptor density in rat brainstem. ANESTHESIOLOGY 1982; 57:26-30