Supra-agonist peptides enhance the reactivation of memory CTL responses

Journal of Immunology

Volumn 165, Issue 8, 2000, Pages 4264-4271

  Micheletti, F ^a   Canella, A ^a   Vertuani, S ^a   Marastoni, M ^a   Tosi, L ^a   Volinia, S ^a   Traniello, S ^a   Gavioli, R ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; PEPTIDE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL FUNCTION; CELL STIMULATION; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; IMMUNOREACTIVITY; KIDNEY CELL; LYMPHOCYTE PROLIFERATION; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0034667772     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.8.4264     Document Type: Article

References (47)

1. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
2. b
3. The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2
4. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2
5. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complexes using different TCR amino acids
6. Structural basis of plasticity in T cell recognition of a self peptide-MHC antigen
7. TCR binding to peptide-MHC stabilizes a flexible recognition interface
8. Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
9. T cell receptor antagonists and partial agonists
10. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
11. A single specific amino acid residue in peptide antigens is sufficient to activate memory cytotoxic T lymphocytes: Potential role of cross-reactive peptides in memory T cell maintenance
12. A very high level of crossreactivity is an essential feature of the T-cell receptor
13. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
14. Selective activation of the calcium signaling pathway by altered peptide ligands
15. + T cells in response to antagonist ligands
16. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor
17. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
18. High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
19. Selective amino acid substitutions of a subdominant Epstein-Barr virus LMP2-derived epitope increase HLA/peptide complex stability and immunogenicity: Implications for immunotherapy of Epstein-Barr virus-associated malignancies
20. HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2
21. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene
22. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: Role of T cell actin cytoskeleton
23. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
24. 2+ signals and immunosuppression
25. Antigen analog-major histocompatibility complexes act as antagonist of the T cell receptor
26. Impaired assembly and transport of HLA-A and -B antigens in a mutant TXB cell hybrid
27. Multiple HLA A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4
28. Effect of anchor residue modifications on the stability of HLA-A11/peptide complexes
29. High structural side chain specificity required at the second position of immunogenic peptides to obtain stable MHC/peptide complexes
30. Activation of epitope-specific memory cytotoxic T lymphocyte responses by synthetic peptides
31. Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA A11 restricted cytotoxic T lymphocytes: Implications for the down-regulation of HLA A11 in Burkitt's lymphoma
32. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules
33. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
34. Detailed motifs for peptide binding to HLA-A0201 derived from large random sets of peptides using a cellular binding assay
35. The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions
36. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues
37. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability
38. The lifespan of MHC class I/complexes determines the efficiency of cytotoxic T lymphocyte responses
39. The minimum peptide epitope from the influenza virus matrix protein: Extra and intracellular loading of HLA-A2
40. Antagonist HIV-1Gag peptides induce structural changes in HLA B8
41. Protection against lethal viral infection by vaccination with nonimmunodominant peptides
42. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4
43. Chimeric peptides: A new approach to enhancing the immunogenicity of peptides with low MHC class I affinity: Application in antiviral vaccination
44. The duration of antigenic stimulation determines the fate of naive and effector T cells
45. Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides
46. Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism
47. T-cell development: A role for self-peptides in positive selection