Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel

Neuron

Volumn 16, Issue 4, 1996, Pages 869-880

  Premkumar, Louis S ^a   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MANGANESE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM BINDING; CHANNEL GATING; ELECTRIC FIELD; ELECTROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; XENOPUS LAEVIS;

EID: 0030006183     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80107-5     Document Type: Article

References (41)

1. Almers, W., and McCleskey E.W. (1984). Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. J. Physiol. (Lond) 353, 585-608.
2. Ascher, P., and Nowak, L. (1988). The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. J. Physiol. (Lond) 399, 247-266.
3. Bliss, T.V.P., and Collingridge, G.L. (1993). A synaptic model for memory-long-term potentiation in the hippocampus. Nature 361, 31-39.
4. Burnashev, N., Monyer, H., Seeburg, P.H., and Sakmann, B. (1992a). Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8, 189-198.
5. Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J.P., Gunther, W., and Seeburg, P.H., and Sakmann, B. (1992b). Control by aspargine residues of calcium permeability and magnesium blockade in NMDA receptor. Science 257, 1415-1419.
6. Burnashev, N., Zhou, Z., Neher, E., and Sakmann, B. (1995). Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA, and kainate receptor subtypes. J. Physiol. (Lond.) 485, 403-418.
7. Butler, J.N. (1968). The thermodynamic activity of calcium ion in sodium chloride-calcium chloride electrolytes. Biophys. J. 8, 1426-1433.
8. Choi, D.N., and Rothman, S.M. (1990). The role of glutamate neurotoxicity in hypoxic-ischemia neuronal death. Annu. Rev. Neurosci. 13, 171-182.
9. Chung, S.H., Moore, J.B., Xia, L., Premkumar, L.S., and Gage, P.W. (1990). Characterization of single channel currents using digital signal processing techniques based on Hidden Markov Models. Phil. Trans. Roy. Soc. (Lond.) B 329, 265-285.
10. Constantine-Paton, M. (1990). NMDA receptor as a mediator of activity dependent synaptogenesis in the developing brain. Cold Spring Harbor Symp. Quant. Biol. 55, 431-443.
11. Fabiato, A. (1988). [31] computer programs for calculating total from specified free or free from specified total ionic concentrations in aquous solutions containing multiple methods and ligands. Meth. Enzymol. 157, 378-416.
12. Gibb, A.J., and Colquhoun, D. (1992). Activation of N-methyl-D-aspartate receptor by L-glutamate in cells dissociated from adult rat hippocampus. J. Physiol. (Lond) 456, 143-179.
13. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F.J. (1981). Improved patch-clamp technique for high resolution current recording from cell and cell-free membrane patches. Pflügers Arch. 391, 85-100.
14. Hess, P., and Tsien, R.W. (1984). Mechanism of ion permeation through calcium channels. Nature 309, 453-456.
15. Hille, B. (1992). Ionic Channels of Excitable Membranes (Massachusetts: Sinauer Associates).
16. Hume, R.I., Dingledine, R., and Heinemann, S.F. (1991). Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253, 1028-1031.
17. Jahr, C.E., and Stevens, C.F. (1993). Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture. Proc. Natl. Acad. Sci. USA 90, 11573-11577.
18. 2+ of N-methyl-D-aspartate-activated channels. Biophys. J. 57, 1085-1090.
19. Jonas, P., and Burnashev, N. (1995). Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptors channels. Neuron 15, 987-990.
20. + channels. Science 250, 276-279.
21. Maconochie, D.J., and Knight, D.E. (1989). A method for making solution changes in the submillisecond range at the tip of a patch pipette. Pflügers Arch. 414, 589-596.
22. Mayer, M.L., and Westbrook, G.L. (1987). Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J. Physiol. (Lond) 394, 501-527.
23. McBain, C.J., and Mayer, M.L. (1994). N-Methyl-D-Aspartic acid receptor structure and function. Physiol. Rev. 74, 723-760.
24. Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., and Mishina, M. (1992). Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357, 70-74.
25. Meldrum, B., and Garthwaite, J. (1990). Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11, 379-387.
26. Methfessel, C., Witzemann, V., Takahashi, T., Mishina, M., Numa, S., and Sakmann, B. (1986). Patch clamp measurement on Xenopus laevis oocyte, current through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Arch. 407, 577-588.
27. ++-block site of the NMDA receptor channel. Nature 358, 673-675.
28. Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., and Nakanishi, S. (1991). Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
29. Nakazawa, K., and Hess, P. (1993). Block by calcium of ATP-activated channels in pheochromacytoma cells. J. Gen. Physiol. 101, 377-392.
30. Nowak, L.M., Bregestovski, P., Ascher, P., Herbert, A., and Prochiantz, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307, 462-465.
31. 2+. Neuron 15, 1109-1120.
32. Root, M.J., and Mackinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science 265, 1852-1856.
33. Ruppersberg, J.P., Mosbacher, J., Gunther, W., Schoepfer, R., and Fakler, B. (1993). Studying block in cloned N-methyl-D-aspartate (NMDA) receptors. Biochem. Pharmacol. 46, 1877-1885.
34. 2+ and channel blockers by single aminoacid substitution in the N-methyl-D-aspartate receptor. J. Biol. Chem. 268, 410-415.
35. 2+-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions on a multi-ion channel. Biophys. J. 66, 654-666.
36. Schneggenburger, R., Zhou, Z., Konnerth, A., and Neher, E. (1993). Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron 11, 133-143.
37. Stern, P., Behe, P. Schoepfer, R., and Colquhoun, D. (1992). Single-channel conductances of NMDA receptors expressed from cloned cDNAs, comparison with native receptors. Proc. R. Soc. Lond. (Biol.) 250, 271-277.
38. Verdoorn, T.A., Burnashev, N., Monyer, H., Seeburg, P.H., and Sakmann, B. (1991). Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252, 1715-1718.
39. Villarroel, A., Burnashev, N., and Sakmann, B. (1995). Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys. J. 68, 866-875.
40. Zarei, M.M., and Dani, J.A. (1994). Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel. J. Gen. Physiol. 103, 231-248.
41. Zarei, M.M., and Dani, J.A. (1995). Structural basis for explaining open-channel blockade of the NMDA receptor. J. Neurosci. 15, 1446-1454.