Orientations and locations of local anesthetics benzocaine and butamben in phospholipid membranes as studied by 2H NMR spectroscopy

Journal of Membrane Biology

Volumn 177, Issue 2, 2000, Pages 117-128

  Kuroda, Y ^a   Nasu, H ^a   Fujiwara, Y ^b   Nakagawa, T ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2H NMR; Benzocaine; Butamben; Local anesthetics; Phospholipid membranes; Sodium channels

Indexed keywords

AROMATIC COMPOUND; BENZOCAINE; BUTYLCAINE; CARBON; CHOLESTEROL; DEUTERIUM; GLYCEROL; LOCAL ANESTHETIC AGENT; PALMITIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SODIUM;

ARTICLE; CALCULATION; CONTROLLED STUDY; DEUTERON NUCLEAR MAGNETIC RESONANCE; DRUG DISTRIBUTION; DRUG STRUCTURE; ISOTOPE LABELING; PHOSPHOLIPID MEMBRANE; SODIUM CHANNEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANESTHETICS, LOCAL; BENZOCAINE; CHOLESTEROL; COMPARATIVE STUDY; DEUTERIUM; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; PALMITIC ACID; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034665590     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320001105     Document Type: Article

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