NMR study directly determining drug delivery sites in phospholipid bilayer membranes

Journal of Physical Chemistry B

Volumn 103, Issue 17, 1999, Pages 3505-3509

  Okamura, Emiko ^a   Nakahara, Masaru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000174475     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp984621e     Document Type: Article

References (13)

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4. Okamura, E.; Kakitsubo, R.; Nakahara, M. To be published.
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12. In parts b-e of Figure 2, there is a small but broad peak around 7.24-7.3 ppm, which is a high field compared to the strong sharp peak. The chemical shift of this peak is also changed by LIS. It could be assigned to the ring proton of BzOH trapped in the outer layer of some smaller vesicles.
13. Here, we show the results of the BzOH/EPC system. A remarkable change is successfully detected, since a high drug/lipid ratio can be attained by the high solubility of BzOH in water.