Analysis of association at single nucleotide polymorphisms in the APOE region

Genomics

Volumn 63, Issue 1, 2000, Pages 7-12

  Martin, Eden R ^a   Gilbert, John R ^a   Lai, Eric H ^b   Riley, John ^c   Rogala, Allison R ^a   Slotterbeck, Brandon D ^a   Sipe, Catherine A ^a   Grubber, Janet M ^a   Warren, Liling L ^a   Conneally, P Michael ^d   Saunders, Ann M ^a   Schmechel, Donald E ^a   Purvis, Ian ^c   Pericak Vance, Margaret A ^a   Roses, Allen D ^a,b   Vance, Jeffery M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; NUCLEOTIDE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0034003082     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1999.6057     Document Type: Article

References (38)

1. Blacker D., Haines J. L., Rodes L., Terwedow H., Go R. C. P., Harrell L. E., Perry R. T., Bassett S. S., Chase G., Meyers D., Albert M. S., Tanzi R. ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative. Neurology. 48:1997;139-147.
2. Bodmer W. F. Human genetics: The molecular challenge. Cold Spring Harbor Symp. Quant. Biol. 51:1986;1-13.
3. Collins F., Galas D. A new five-year plan for the U. S. Human Genome Project. Science. 262:1993;43-46.
4. Collins F. S., Brooks L. D., Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res. 8:1998;1229-1231.
5. Corder E. H., Saunders A. M., Risch N. J., Strittmatter W. J., Schmechel D. E., Gaskell P. C. Jr., Rimmler J. B., Locke P. A., Conneally P. M., Schmader K. E., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A. Protective effect of apoliprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7:1994;180-184.
6. Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
7. Curtis D. Use of siblings as controls in case-control association studies. Ann. Hum. Genet. 61:1997;319-333.
8. Ewens W. J., Spielman R. S. The transmission/disequilibrium test: History, subdivision, and admixture. Am. J. Hum. Genet. 57:1995;455-464.
9. Hauser E. R., Boehnke M. Confirmation of linkage results in affected-sib-pair linkage analysis for complex genetic traits. Am. J. Hum. Genet. 61:1997;A278.
10. Horvath S. M., Laird N. M. A discordant-sibship test for disequilibrium and linkage: No need for parental data. Am. J. Hum. Genet. 63:1998;1886-1897.
11. Jorde L. B., Watkins W. S., Viskochil D., O'Connell P., Ward K. Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: Implications for gene mapping. Am. J. Hum. Genet. 53:1993;1038-1050.
12. Kwok P. Y., Deng Q., Zakeri H., Taylor S. L. Increasing the information content of STS-based genome maps: Identifying polymorphisms in mapped STSs. Genomics. 31:1996;123-126.
13. Lai E., Riley J., Purvis I., Roses A. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics. 54:1998;31-38.
14. Lauer S. J., Walker D., Elshourbagy N. A., Reardon C. A., Levy-Wilson B., Taylor J. M. Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. J. Biol. Chem. 263:1988;7277-7286.
15. Louisiana State University Medical Center, 1994, SAGE: Statistical Analysis for Genetic Epidemiology, version 2.2, Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans. [Computer program].
16. Marshall E. Genomics: Drug firms to create public database of genetic mutations. Science. 284:1999;406-407.
17. Menzel H. J., Kladetzky R. G., Asman G. Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis. 3:1983;310-315.
18. Monks S. A., Kaplan N. L., Weir B. S. A comparative study of sibship tests of linkage and/or association. Am. J. Hum. Genet. 63:1998;1507-1516.
19. Namba Y., Tamonaga M., Kawasaki H., Otomo E., Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and cru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:1991;163-166.
20. Pennisi E. A closer look at SNPs suggests difficulties. Science. 281:1998;1787-1789.
21. Pericak-Vance M. A., Bass M. P., Yamaoka L. H., Gaskell P. C., Scott W. K., Terwedow H. A., Menold M. M., Conneally P. M., Small G. W., Vance J. M., Saunders A. M., Roses A. D., Haines J. L. Complete genomic screen in late-onset familial Alzheimer disease: Evidence for a new locus on chromosome 12. J. Am. Med. Assoc. 278:1997;1237-1241.
22. Pericak-Vance M. A., Bebout J. L., Gaskell P. C., Yamaoka L. H., Hung W. Y., Alberts M. J., Walker A. P., Bartlett R. J., Haynes C. S., Welsh K. A., Earl N. L., Heyman A., Clark C. M., Roses A. D. Linkage studies in familial Alzheimer's disease: Evidence for chromosome 19 linkage. Am. J. Hum. Genet. 48:1991;1034-1050.
23. Pericak-Vance M. A., Conneally P. M., Gaskell P. C., Small G. W., Saunders A. M., Yamaoka L. H., Robinson C., Ter-Minassian M., Locker P. A., Pritchard M., Haynes C. S., Growden J., Tanzi R. E., Gusella J. F., Roses A. D., Haines J. L. The search for additional late-onset Alzheimer disease gene: A complete genomic screen. J. Hum. Genet. 57:1995;A200.
24. Poduslo S. E., Neal M., Schwankhaus J. A closely linked gene to apolipoprotein E may serve as an additional risk factor for Alzheimer's disease. Neurosci. Lett. 201:1995;81-83.
25. Rimmler J., McDowell J. G., Slotterback B. D., Haynes C. S., Menold M. M., Rogala A., Speer M. C., Gilbert J. R., Hauser E. R., Vance J. M., Pericak-Vance M. A. Development of a data coordinating center (DCC): Data quality control for complex disease studies. Am. Soc. Hum. Genet. 63:1998;A240.
26. Risch N., Merikangas K. The future of genetic studies of complex human disorders. Science. 273:1996;1516-1517.
27. Roses A. D., Pericak-Vance M. A. Alzheimer's disease and other dementias. Rimoin D. L. Emery and Rimoin's Principles and Practice of Medical Genetics. 1997;1807-1825 Churchill, New York.
28. Saunders A. M., Strittmatter W. J., Schmechel D., St. Pericak-Vance M. A., Joo S. H., Rosi B. L., Gusella J. F., Crapper-MacLachlan D. R., Alberts M. J., Hulette C., Crain B., Goldgaber D., Roses A. D. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43:1993;1467-1472.
29. Schellenberg G. D., Deeb S. S., Boehnke M., Bryant E. M., Martin G. M., Lampe T. H., Bird T. D. Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J. Neurogenet. 4:1987;97-108.
30. Schlesselman J. J. Case-Control Studies. Design, Conduct, Analysis. 1982;Oxford Univ. Press, New York, Oxford.
31. Schmechel D. E., Saunders A. M., Strittmatter W. J. Increased amyloid β peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late onset Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 90:1993;9649-9653.
32. Spielman R. S., Ewens W. J. A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test. Am. J. Hum. Genet. 62:1998;450-458.
33. Strittmatter W. J., Saunders A. M., Pericak-Vance M. A., Salvesen G. S., English J., Roses A. D. Apolipoprotein E: High avidity binding to a βA amyloid and increased frequency of type 4 isoform in familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 90:1993a;1977-1981.
34. Strittmatter W. J., Weisgraber K. H., Huang D. Y., Dong L. M., Salvesen G. S., Pericak-Vance M., Schmechel D., Saunders A. M., Goldgaber D., Roses A. D. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993b;8098-8102.
35. Wang D. G., Fan J. B., Siao C. J., Berno A., Young P., Sapolsky R., Ghandour G., Perkins N., Winchester E., Spencer J., Kruglyak L., Stein L., Hsie L., Topaloglou T., Hubbell E., Robinson E., Mittmann M., Morris M. S., Shen N., Kilburn D., Rioux J., Nusbaum C., Rozen S., Hudson T. J., Lipshutz R., Chee M., Lander E. S. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 280:1998;1077-1081.
36. Weir, B. S. 1996, Genetic Analysis II, Sinaur Associates, Sunderland, MA.
37. Weisgraber K. H. Apolipoprotein E: Structure-function relationships. Advances in Protein Chemistry. 1994;Academic Press, New York. p. 249-302.
38. Yu C. E., Payami H., Olson J. M., Boehnke M., Wijsman E. M., Orr H. T., Kukull W. A., Goddard K. A., Nemens E., White J. A. The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am. J. Hum. Genet. 54:1994;631-642.