Cytotoxic T-lymphocyte responses to a polymorphic Epstein-Barr virus epitope identify healthy carriers with coresident viral strains

Journal of Virology

Volumn 74, Issue 4, 2000, Pages 1801-1809

  Brooks, J M ^a   Croom Carter, D S G ^a   Leese, A M ^a   Tierney, R J ^a   Habeshaw, G ^a   Rickinson, A B ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA B27 ANTIGEN; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SUPERINFECTION; VIRUS CARRIER; VIRUS ISOLATION; VIRUS STRAIN;

ADULT; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; BASE SEQUENCE; CARRIER STATE; CELLS, CULTURED; DNA, VIRAL; EPITOPES, T-LYMPHOCYTE; EPSTEIN-BARR VIRUS INFECTIONS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HEALTH STATUS; HERPESVIRUS 4, HUMAN; HLA-B27 ANTIGEN; HUMANS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033944625     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.4.1801-1809.2000     Document Type: Article

References (38)

1. Abdel-Hamid, M., J. J. Chen, N. Constantine, M. Massoud, and N. Raab-Traub. 1992. EBV strain variation: geographical distribution and relation to disease state. Virology 190:168-175.
2. Aitken, C., S. K. Sengupta, C. Aedes, D. J. Moss, and T. B. Sculley. 1994. Heterogeneity within the Epstein-Barr virus nuclear antigen 2 gene in different strains of Epstein-Barr virus. J. Gen. Virol. 75:95-100.
3. Apolloni, A., D. Moss, R. Stumm, S. Burrows, A. Suhrbier, I. Misko, C. Schmidt, and T. Sculley. 1992. Sequence variation of cytotoxic T cell epitopes in different isolates of Epstein-Barr virus. Eur. J. Immunol. 22:183-189.
4. Apolloni, A., and T. B. Sculley. 1994. Detection of A-type and B-type Epstein-Barr virus in throat washings and lymphocytes. Virology 202:978-981.
5. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccardori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407-410.
6. Bhatia, K., A. Raj, M. I. Gutierrez, J.-G. Judde, G. Spangler, H. Venkatesh, and I. T. Magrath. 1996. Variation in the sequence of Epstein-Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomas. Oncogene 13:177-181.
7. Brooks, J. M., R. Murray, W. A. Thomas, M. G. Kurilla, and A. B. Rickinson. 1993. Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. J. Exp. Med. 178:879-887.
8. Brooks, J. M., R. A. Colbert, J. P. Mear, A. M. Leese, and A. B. Rickinson. 1998. HLA-B27 subtype polymorphism and CTL epitope choice: studies with EBV peptides link immunogenicity with stability of the B27:peptide complex. J. Immunol. 161:5252-5259.
9. Buisson, M., P. Morand, O. Genoulaz, M.-J. Bourgeat, M. Micoud, and J.-M. Seigneurin. 1994. Changes in the dominant Epstein-Barr virus type during human immunodeficiency virus infection. J. Gen. Virol. 75:431-437.
10. Dambaugh, T., K. Hennessy, L. Chamnankit, and E. Kieff. 1984. U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. Proc. Natl. Acad. Sci. USA 81:7632-7636.
11. de Campos-Lima, P. O., V. Levitsky, J. Brooks, S. P. Lee, L. F. Hu, A. B. Rickinson, and M. G. Masucci. 1994. T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues. J. Exp. Med. 179:1297-1305.
12. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-299.
13. Goulder, P. J. R., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. J. McMichael, and S. Rowland-Jones. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3:212-217.
14. Gratama, J. W., M. A. P. Oosterveer, W. Weimar, K. Sintnicolaas, W. Sizoo, R. L. H. Bolhuis, and I. Ernberg. 1994. Detection of multiple 'Ebnotypes' in individual Epstein-Barr virus carriers following lymphocyte transformation by virus derived from peripheral blood and oropharynx. J. Gen. Virol. 75: 85-94.
15. Habeshaw, G., Q. Y. Yao, A. I. Bell, D. Morton, and A. B. Rickinson. 1999. Epstein-Barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas. J. Virol. 73:965-975.
16. Jardetsky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self-peptides bound to purified HLA-B27. Nature 353:326-329.
17. Khanna, R., R. W. Slade, L. Poulsen, D. J. Moss, S. R. Burrows, J. Nicholls, and J. M. Burrows. 1997. Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift. J. Virol. 71:8340-8346.
18. Kyaw, M. T., L. Hurren, L. Evans, D. J. Moss, D. A. Cooper, E. Benson, E. Esmore, and T. B. Sculley. 1992. Expression of B-type Epstein-Barr virus in HIV-infected patients and cardiac transplant recipients. AIDS Res. Hum. Retrovir. 8:1869-1874.
19. Lee, S. P., R. J. Tierney, W. A. Thomas, J. M. Brooks, and A. B. Rickinson. 1997. Conserved CTL epitopes within EBV latent membrane protein 2. A potential target for CTL-based tumor therapy. J. Immunol. 158:3325-3334.
20. Lung, M. L., W. P. Lam, K. H. Chan, S. Li, J. Sham, and D. Choy. 1992. Direct detection of Epstein-Barr virus in peripheral blood and comparison of Epstein-Barr virus genotypes present in direct specimens and lymphoblastoid cell lines established from nasopharyngeal carcinoma patients and healthy carriers in Hong Kong. Int. J. Cancer 52:174-177.
21. Moss, D. J., I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, and T. B. Sculley. 1988. Cytotoxic T-cell clones discriminate between A-and B-type transformants. Nature 331:719-721.
22. Pazmany, L., S. Rowland-Jones, S. Huet, A. Hill, J. Sutton, R. Murray, J. Brooks, and A. McMichael. 1992. Genetic modulation of antigen presentation by HLA-B27 molecules. J. Exp. Med. 175:361-369.
23. Phillips, R. E., S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. M. Bangham, C. R. Rizza, and A. J. McMichael. 1991. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453-459.
24. Rickinson, A. B., L. S. Young, and M. Rowe. 1987. Influence of the Epstein-Barr virus nuclear antigen EBNA2 on the growth phenotype of virus-transformed B cells. J. Virol. 61:1310-1317.
25. Rickinson, A. B., and E. Kieff. 1996. Epstein-Barr virus. p. 2397-2446. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
26. Rickinson, A. B., and D. J. Moss. 1997. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu. Rev. Immunol. 15:405-431.
27. Sample, J., L. Young, B. Martin, T. Chatman, E. Kieff, A. Rickinson, and E. Kieff. 1990. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J. Virol, 64:4084-4092.
28. Sculley, T. B., A. Apolloni, L. Hurren, D. J. Moss, and D. A. Cooper. 1990. Co-infection with A-and B-type Epstein-Barr virus in human immunodeficiency virus-positive subjects. J. Infect. Dis. 162:643-648.
29. Sixbey, J. W., P. Shirley, P. J. Chesney, D. M. Buntin, and L. Resnick. 1989. Detection of a second widespread strain of Epstein-Barr virus. Lancet ii: 761-765.
30. Snudden, D. K., P. R. Smith, D. Lai, M. H. Ng, and B. Griffin. 1995. Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours. Oncogene 10:1545-1552.
31. Sung, N. S., R. H. Edwards, F. Seillier-Moiseiwitsch, A. G. Perkins, Y. Zeng, and N. Raab-Traub. 1998. EBV strain variation in nasopharyngeal carcinoma from the endemic and non-endemic regions of China. Int. J. Cancer 76:207-215.
32. van Baarle, D., E. Hovenkamp, M. J. Kersten, M. R. Klein, F. Miedema, and M. H. J. van Oers. 1999. Direct Epstein-Barr virus (EBV) typing on peripheral blood mononuclear cells: no association between EBV type 2 infection or superinfection and the development of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Blood 93:3949-3955.
33. Walling, D. M., S. N. Edmistan, J. W. Sixbey, M. Abdel-Hamid, L. Resnick, and N. Raab-Traub. 1992. Co-infection of multiple strains of the Epstein-Barr virus in human immunodeficiency virus-associated hairy leukoplakia. Proc. Natl. Acad. Sci. USA 89:6560-6564.
34. Wrightham, M. N,. J. P. Stewart, N. J. Janjua, S. D. V. Pepper, C. Sample, C. M. Rooney, and J. R. Arrand. 1995. Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1. Virology 208:521-530.
35. Yao, Q. Y., M. Rowe, B. Martin, L. S. Young, and A. B. Rickinson. 1991. The Epstein-Barr virus carrier state: dominance of a single growth-transforming isolate in the blood and in the oropharynx of healthy virus carriers. J. Gen. Virol. 72:1579-1590.
36. Yao, Q. Y., R. J. Tierney, D. Croom-Carter, D. Dukers, G. M. Cooper, C. J. Ellis, M. Rowe, and A. B. Rickinson. 1996. Frequency of multiple Epstein-Barr virus infections in T-cell immunocompromised individuals. J. Virol. 70:4884-4894.
37. Yao, Q. Y., D. S. G. Croom-Carter, R. J. Tierney, G. Habeshaw, J. T. Wilde, F. G. H. Hill, C. Conlon, and A. B. Rickinson. 1998. Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell immunocompromised hemophiliac cohort. J. Virol. 72:4352-4363.
38. Zimber, U., H. K. Adldinger, G. M. Lenoir, M. Vuillaume, M. V. Knebel-Doeberitz, G. Laux, C. Desgranges, P. Wittman, U. K. Freese, U. Schneider, and G. W. Bornkamm. 1986. Geographic prevalence of two Epstein-Barr virus types. Virology 154:56-66.