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Volumn 95, Issue 10, 2000, Pages 3153-3161

Blockade of CD86 and CD40 induces alloantigen-specific immunoregulatory T cells that remain anergic even after reversal of hyporesponsiveness

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034657951     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.10.3153.010k12_3153_3161     Document Type: Article
Times cited : (57)

References (56)
  • 1
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 1998;280:243.
    • (1998) Science , vol.280 , pp. 243
    • Van Parijs, L.1    Abbas, A.K.2
  • 2
    • 0030722507 scopus 로고    scopus 로고
    • Transplantation tolerance - Putting the pieces together
    • Lechler R, Bluestone JA. Transplantation tolerance - putting the pieces together. Curr Opin Immunol. 1997;9:631.
    • (1997) Curr Opin Immunol. , vol.9 , pp. 631
    • Lechler, R.1    Bluestone, J.A.2
  • 3
    • 0025755292 scopus 로고
    • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
    • Ohashi PS, Oehen S, Buerki K, et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 1991;65:305.
    • (1991) Cell , vol.65 , pp. 305
    • Ohashi, P.S.1    Oehen, S.2    Buerki, K.3
  • 4
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996;381:434.
    • (1996) Nature , vol.381 , pp. 434
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 5
    • 0028957496 scopus 로고
    • Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
    • Rocha B, Grandien A, Freitas AA. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J Exp Med. 1995;181: 993.
    • (1995) J Exp Med. , vol.181 , pp. 993
    • Rocha, B.1    Grandien, A.2    Freitas, A.A.3
  • 6
    • 0025908321 scopus 로고
    • Peripheral selection of the T cell repertoire
    • Rocha B, von Boehmer H. Peripheral selection of the T cell repertoire. Science. 1991;251:1225.
    • (1991) Science , vol.251 , pp. 1225
    • Rocha, B.1    Von Boehmer, H.2
  • 7
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • Webb S, Morris C, Sprent J. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell. 1990;63:1249.
    • (1990) Cell , vol.63 , pp. 1249
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 8
    • 0021809642 scopus 로고
    • Anti-idiotypic T cells suppress rejection of renal allografts in rats
    • Lancaster F, Chui YL, Batchelor JR. Anti-idiotypic T cells suppress rejection of renal allografts in rats. Nature. 1985;315:336.
    • (1985) Nature , vol.315 , pp. 336
    • Lancaster, F.1    Chui, Y.L.2    Batchelor, J.R.3
  • 10
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994;265:1237.
    • (1994) Science , vol.265 , pp. 1237
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 11
    • 0031573671 scopus 로고    scopus 로고
    • Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells
    • Marelli-Berg FM, Weetman A, Frasca L. et al. Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells. J Immunol. 1997; 159:5853.
    • (1997) J Immunol. , vol.159 , pp. 5853
    • Marelli-Berg, F.M.1    Weetman, A.2    Frasca, L.3
  • 12
    • 0027479685 scopus 로고
    • "Infectious" transplantation tolerance
    • Qin S, Cobbold SP, Pope H, et al. "Infectious" transplantation tolerance. Science. 1993;259: 974.
    • (1993) Science , vol.259 , pp. 974
    • Qin, S.1    Cobbold, S.P.2    Pope, H.3
  • 13
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998;188:287.
    • (1998) J Exp Med. , vol.188 , pp. 287
    • Thornton, A.M.1    Shevach, E.M.2
  • 14
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997;389: 737.
    • (1997) Nature , vol.389 , pp. 737
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 15
    • 0032861775 scopus 로고    scopus 로고
    • What is the role of regulatory T cells in transplantation tolerance?
    • Zhai Y, Kupiec Weglinski JW. What is the role of regulatory T cells in transplantation tolerance? Curr Opin Immunol. 1999;11:497.
    • (1999) Curr Opin Immunol. , vol.11 , pp. 497
    • Zhai, Y.1    Kupiec Weglinski, J.W.2
  • 16
    • 0033032992 scopus 로고    scopus 로고
    • Anergic T cells act as suppressor cells in vitro and in vivo
    • Chai JG, Bartok I, Chandler P, et al. Anergic T cells act as suppressor cells in vitro and in vivo. Eur J Immunol. 1999;29:686.
    • (1999) Eur J Immunol. , vol.29 , pp. 686
    • Chai, J.G.1    Bartok, I.2    Chandler, P.3
  • 17
    • 0029918208 scopus 로고    scopus 로고
    • T cell suppression in transplantation tolerance through linked recognition
    • Davies JD, Leong LY, Mellor A, Cobbold SP, Waldmann H. T cell suppression in transplantation tolerance through linked recognition. J Immunol. 1996;156:3602.
    • (1996) J Immunol. , vol.156 , pp. 3602
    • Davies, J.D.1    Leong, L.Y.2    Mellor, A.3    Cobbold, S.P.4    Waldmann, H.5
  • 18
    • 0020639827 scopus 로고
    • Haplotype-specific suppressor T cells mediating linked suppression of immune responses elicited by third-party H-2 alloantigens
    • Holan V, Mitchison NA. Haplotype-specific suppressor T cells mediating linked suppression of immune responses elicited by third-party H-2 alloantigens. Eur J Immunol. 1983;13:652.
    • (1983) Eur J Immunol. , vol.13 , pp. 652
    • Holan, V.1    Mitchison, N.A.2
  • 19
    • 0030240965 scopus 로고    scopus 로고
    • Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients
    • Onodera K, Lehmann M, Akalin E, et al. Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol. 1996;157:1944.
    • (1996) J Immunol. , vol.157 , pp. 1944
    • Onodera, K.1    Lehmann, M.2    Akalin, E.3
  • 20
    • 0025339511 scopus 로고
    • A cell culture model tor T lymphocyte clonal anergy
    • Schwarte RH. A cell culture model tor T lymphocyte clonal anergy. Science. 1990;248:1349.
    • (1990) Science , vol.248 , pp. 1349
    • Schwarte, R.H.1
  • 21
    • 0023885038 scopus 로고
    • Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells
    • Jenkins MK, Ashwell JD, Schwartz RH. Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells. J Immunol. 1988;140:3324.
    • (1988) J Immunol. , vol.140 , pp. 3324
    • Jenkins, M.K.1    Ashwell, J.D.2    Schwartz, R.H.3
  • 22
    • 0026537347 scopus 로고
    • C028-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding FA, McArthur JG, Gross JA, Raulet DH. Allison JP. C028-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607.
    • (1992) Nature , vol.356 , pp. 607
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4    Allison, J.P.5
  • 24
    • 0027397169 scopus 로고
    • Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
    • Tan P, Anasetti C. Hansen JA, et al. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med. 1993;177:165.
    • (1993) J Exp Med. , vol.177 , pp. 165
    • Tan, P.1    Anasetti, C.2    Hansen, J.A.3
  • 25
    • 0026738641 scopus 로고
    • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg
    • Lenschow DJ, Zeng Y, Thistlethwaite JR, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science. 1992;257: 789.
    • (1992) Science , vol.257 , pp. 789
    • Lenschow, D.J.1    Zeng, Y.2    Thistlethwaite, J.R.3
  • 26
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995;80:707.
    • (1995) Cell , vol.80 , pp. 707
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3
  • 27
    • 0029744798 scopus 로고    scopus 로고
    • Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
    • Grewal IS, Foellmer HG, Grewal KD, et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 1996;273:1864.
    • (1996) Science , vol.273 , pp. 1864
    • Grewal, I.S.1    Foellmer, H.G.2    Grewal, K.D.3
  • 28
    • 0029780119 scopus 로고    scopus 로고
    • CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
    • Yang Y, Wilson JM. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science. 1996;273:1862.
    • (1996) Science , vol.273 , pp. 1862
    • Yang, Y.1    Wilson, J.M.2
  • 29
    • 0028826268 scopus 로고
    • Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies
    • Lenschow DJ, Zeng Y, Hathcock KS, et al. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation. 1995;60:1171.
    • (1995) Transplantation , vol.60 , pp. 1171
    • Lenschow, D.J.1    Zeng, Y.2    Hathcock, K.S.3
  • 30
    • 0031203940 scopus 로고    scopus 로고
    • The role of donor and recipient B7-1 (CD80) in allograft rejection
    • Zheng XX, Sayegh MH, Zheng XG, et al. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol. 1997;159:1169.
    • (1997) J Immunol. , vol.159 , pp. 1169
    • Zheng, X.X.1    Sayegh, M.H.2    Zheng, X.G.3
  • 31
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4lg plus donor-specific transfusion
    • Lin H, Boiling SF, Linsley PS, et al. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4lg plus donor-specific transfusion. J Exp Med. 1993;178:1801.
    • (1993) J Exp Med. , vol.178 , pp. 1801
    • Lin, H.1    Boiling, S.F.2    Linsley, P.S.3
  • 32
    • 0032103285 scopus 로고    scopus 로고
    • Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4
    • Martees TG, Phillips NE, Gordon EJ, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest. 1998;101:2446.
    • (1998) J Clin Invest. , vol.101 , pp. 2446
    • Martees, T.G.1    Phillips, N.E.2    Gordon, E.J.3
  • 33
    • 0030860995 scopus 로고    scopus 로고
    • Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand
    • Markees TG, Phillips NE, Noelle RJ, et al. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation. 1997;64:329.
    • (1997) Transplantation , vol.64 , pp. 329
    • Markees, T.G.1    Phillips, N.E.2    Noelle, R.J.3
  • 34
    • 0028882526 scopus 로고
    • Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
    • Parker DC, Greiner DL, Phillips NE, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A. 1995;92:9560.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9560
    • Parker, D.C.1    Greiner, D.L.2    Phillips, N.E.3
  • 35
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA. 1996;93:13,967.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13967
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3    Peach, R.4    Linsley, P.S.5    Turka, L.A.6
  • 36
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med. 1999;5:686.
    • (1999) Nat Med. , vol.5 , pp. 686
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 37
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D. et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation. 1996;61:4.
    • (1996) Transplantation , vol.61 , pp. 4
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 38
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-lg and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-lg and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA. 1997;94:8789.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8789
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 39
    • 0032773310 scopus 로고    scopus 로고
    • Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
    • Van Gool SW, Vermeiren J, Rafiq K, Lorr K, de Boer M, Ceuppens JL. Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production. Eur J Immunol. 1999;29:2367.
    • (1999) Eur J Immunol. , vol.29 , pp. 2367
    • Van Gool, S.W.1    Vermeiren, J.2    Rafiq, K.3    Lorr, K.4    De Boer, M.5    Ceuppens, J.L.6
  • 40
    • 0028880663 scopus 로고
    • Alloantigen-induced human lymphocytes rendered nonresponsive by a combination of anti-CD80 monoclonal antibodies and cyclosporin-A suppress mixed lymphocyte reaction in vitro
    • Comoli P, Montagna D, Moretta A, Zecca M, Locatelli F, Maccario R. Alloantigen-induced human lymphocytes rendered nonresponsive by a combination of anti-CD80 monoclonal antibodies and cyclosporin-A suppress mixed lymphocyte reaction in vitro. J Immunol. 1995;155:5506.
    • (1995) J Immunol. , vol.155 , pp. 5506
    • Comoli, P.1    Montagna, D.2    Moretta, A.3    Zecca, M.4    Locatelli, F.5    Maccario, R.6
  • 41
    • 0031570094 scopus 로고    scopus 로고
    • B7-blocking agents, alone or in combination with cyclosporin A, induce antigen-specific anergy of human memory T cells
    • Yi qun Z, Lorre K, de Boer M, Ceuppens JL. B7-blocking agents, alone or in combination with cyclosporin A, induce antigen-specific anergy of human memory T cells. J Immunol. 1997;158:4734.
    • (1997) J Immunol. , vol.158 , pp. 4734
    • Yi Qun, Z.1    Lorre, K.2    De Boer, M.3    Ceuppens, J.L.4
  • 42
    • 0031686718 scopus 로고    scopus 로고
    • Fine tuning of antigen-presenting cell-directed monoclonal antibody strategies in the induction of human allospecific T-cell tolerance in vitro
    • Koenen HJ, Joosten I. Fine tuning of antigen-presenting cell-directed monoclonal antibody strategies in the induction of human allospecific T-cell tolerance in vitro. Transplant Proc. 1998;30:2447.
    • (1998) Transplant Proc. , vol.30 , pp. 2447
    • Koenen, H.J.1    Joosten, I.2
  • 43
    • 0018174365 scopus 로고
    • T cell growth factor: Parameters of production and a quantitative microassay for activity
    • Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol. 1978;120: 2027.
    • (1978) J Immunol. , vol.120 , pp. 2027
    • Gillis, S.1    Ferm, M.M.2    Ou, W.3    Smith, K.A.4
  • 44
    • 0023914792 scopus 로고
    • Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes
    • Essery G, Feldmann M, Lamb JR. Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology. 1988;64:413.
    • (1988) Immunology , vol.64 , pp. 413
    • Essery, G.1    Feldmann, M.2    Lamb, J.R.3
  • 46
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva DR, Urdahl KB, Jenkins MK. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol. 1991;147:3261.
    • (1991) J Immunol. , vol.147 , pp. 3261
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 47
    • 0023513616 scopus 로고
    • Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways
    • Lamb JR, Zanders ED, Sewell W, Crumpton MJ, Feldmann M, Owen MJ. Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. Eur J Immunol. 1987;17:1641.
    • (1987) Eur J Immunol. , vol.17 , pp. 1641
    • Lamb, J.R.1    Zanders, E.D.2    Sewell, W.3    Crumpton, M.J.4    Feldmann, M.5    Owen, M.J.6
  • 48
    • 0032928907 scopus 로고    scopus 로고
    • Interferon-gamma-based mixed lymphocyte culture as a selection tool tor allogeneic bone marrow donors other than identical siblings
    • van der Meer A, Wissink WM, Schattenberg AV, Joosten I. Interferon-gamma-based mixed lymphocyte culture as a selection tool tor allogeneic bone marrow donors other than identical siblings. Br J Haematol. 1999;105:340.
    • (1999) Br J Haematol. , vol.105 , pp. 340
    • Van Der Meer, A.1    Wissink, W.M.2    Schattenberg, A.V.3    Joosten, I.4
  • 49
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell
    • Ridge JP, Di Rosa F, Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell. Nature. 1998; 393:474.
    • (1998) Nature , vol.393 , pp. 474
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 52
    • 0031048822 scopus 로고    scopus 로고
    • The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
    • Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997;185:219.
    • (1997) J Exp Med. , vol.185 , pp. 219
    • Madrenas, J.1    Chau, L.A.2    Smith, J.3    Bluestone, J.A.4    Germain, R.N.5
  • 53
    • 0033558119 scopus 로고    scopus 로고
    • Dose-dependent induction of distinct anergic phenotypes: Multiple levels of T cell anergy
    • Taams LS, van-Eden W, Wauben MHM. Dose-dependent induction of distinct anergic phenotypes: Multiple levels of T cell anergy. J Immunol. 1999;162:1974.
    • (1999) J Immunol. , vol.162 , pp. 1974
    • Taams, L.S.1    Van-Eden, W.2    Wauben, M.H.M.3
  • 54
    • 0031964338 scopus 로고    scopus 로고
    • Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
    • Buer J, Lanoue A, Franzke A, Garcia C, von Boehmer H, Sarukhan A. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J Exp Med. 1998;187:177.
    • (1998) J Exp Med. , vol.187 , pp. 177
    • Buer, J.1    Lanoue, A.2    Franzke, A.3    Garcia, C.4    Von Boehmer, H.5    Sarukhan, A.6
  • 55
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4 + T cells
    • Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4 + T cells. J Exp Med. 1996;184:19.
    • (1996) J Exp Med. , vol.184 , pp. 19
    • Groux, H.1    Bigler, M.2    De Vries, J.E.3    Roncarolo, M.G.4
  • 56
    • 0028130408 scopus 로고
    • T cells and suppression in vitro
    • Scott B, Kaye J, Lo D. T cells and suppression in vitro. Science. 1994;266:464.
    • (1994) Science , vol.266 , pp. 464
    • Scott, B.1    Kaye, J.2    Lo, D.3


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