Induction of E-selectin expression by double-stranded RNA and TNF-α is attenuated in murine aortic endothelial cells derived from double-stranded RNA-activated kinase (PKR)-null mice

Journal of Immunology

Volumn 164, Issue 4, 2000, Pages 2077-2083

  Bandyopadhyay, Sudip K ^a   De La Motte, Carol A ^a   Williams, Bryan R G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; AORTA; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE INDUCTION; GENE TARGETING; LEUKOCYTE ADHERENCE; MOUSE; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034651653     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.4.2077     Document Type: Article

References (70)

1. Clemens, M. J., J. W. B. Hershey, A. C. Hovanessian, B. C. Jacobs, M. G. Katze, R. J. Kaufman, P. Lengyel, C. E. Samuel, G. C. Sen, and B. R. G. Williams. 1993. PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon. J. Interferon Res. 13:241.
2. Kerr, I. M., R. E. Brown, and A. G. Hovanessian. 1977. Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature 268:540.
3. Meurs, E., K. Chong, J. Galabru, N. S. B. Thomas, I. M. Kerr, B. R. G. Williams, and A. G. Hovanessian. 1990. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62:379.
4. Hovanessian, A. G. 1994. Interferon-induced dsRNA-activated protein kinase (PKR): antiproliferative, antiviral and antitumoral functions. Semin. Virol. 4:237.
5. Samuel, C. E. 1991. Antiviral actions of interferon: interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1.
6. Williams, B. R. G. 1995. The role of dsRNA-activated kinase, PKR, in signal transduction. Semin. Virol. 6:191.
7. Katze, M. G. 1992. The war against the interferon-induced dsRNA-activated protein kinase: can virus win? J. Interferon Res. 12:241.
8. Galabru, J., and A. Hovanessian. 1987. Autophosphorylation of the protein kinase dependent on double-stranded RNA. J. Biol. Chem. 262:15538.
9. Chong, K., L. Feng, K. Schappert, E. Meurs, T. F. Donahue, J. D. Friesen, A. Hovanessian, and B. R. G. Williams. 1992. Human p68 kinase exhibits growth suppression in yeast and homology to the translation regulator GCN2. EMBO J. 11:1513.
10. Dever, T. E., J. I. Chen, G. N. Barber, A. M. Cigan, L. Feng, T. F. Donahue, I. M. London, M. G. Katze, and A. G. Hinnebusch. 1993. Mammalian eukaryotic initiation factor 2 α kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc. Natl. Acad. Sci. USA 90: 4616.
11. Koromilas, A. E., S. Roy, G. Barber, M. G. Katze, and N. Sonenberg. 1992. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science 257:1685.
12. Meurs, E. F. J. Galabru, G. N. Barber, M. G. Katze, and A. G. Hovanessian. 1993. Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 90:232.
13. Zamanian-Daryoush, M., S. D. Der, and B. R. G. Williams. 1999. Cell cycle regulation of the double stranded RNA activated protein kinase, PKR. Oncogene 14:315.
14. Kumar, A., J. Haque, J. Lacoste, J. Hiscott, and B. R. G. Williams. 1994. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. USA 91:6288.
15. Maran, A., R. K. Maitra, A. Kumar, B. Dong, W. Xiao, G. Li, B. R. G. Williams, and R. H. Silverman. 1994. Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A-antisense chimeras. Science 265:789.
16. Yang, Y.-L, L. F. L. Reis, J. Pavlovic, A. Aguzzi, R. Scafter, A. Kumar, B. R. G. Williams, M. Auget, and C. Weissman. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14:6095.
17. Kumar, A., Y.-L. Yang, V. Flati, S. D. Der, S. Kadereit, A. Deb, J. Haque, L. Reis, C. Weissman, and B. R. G. Williams. 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16:406.
18. Der, S. D., Y.-L. Yang, C. Weissmann, and B. R. G. Williams. 1997. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc. Natl. Acad. Sci. USA 94:3279.
19. Takizawa, T. K., K. Ohashi, and Y. Nakanishi. 1996. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. J. Virol. 70:8128.
20. Kibler, K. V., T. Shors, K. B. Perkins, C. C. Zeman, M. P. Banaszac, J. Biesterfeldt, J. O. Langland, and B. L. Jacobs. 1997. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. J. Virol. 71:1992.
21. Lee, S. B., D. Rodriguez, J. R. Rodriguez, and M. Esteban. 1997. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases. Virology 231:81.
22. Srivastava, S. P., K. U. Kumar, and R. J. Kaufman. 1998. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J. Biol. Chem. 273:2416.
23. Yeung, M. C., J. Liu, and A. S. Lau. 1996. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells. Proc. Natl. Acad. Sci. USA 93: 12451.
24. Balachandran, S., C. N. Kim, W. Yeh, T. W. Mak, K. Bhalla, and G. N. Barber. 1998. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 17:6888.
25. Cuddihy, A. R., A. H. Wong, N. W. N. Tam, S. Li, and A. E. Koromilas. 1999. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene 18:2690.
26. Cuddihy, A. R., S. Li, N. W. N. Tam, N. H. Wong, Y. Taya, N. Abraham, J. C. Bell, and A. E. Koromilas. 1999. Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53. Mol. Cell. Biol. 19:2475.
27. Osborn, L. 1990. Leukocyte adhesion to endothelium in inflammation. Cell 62:3.
28. Springer, T. A., 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
29. Carlos, T. M., and Harlan, J. M. 1994. Leukocyte-endothelial adhesion molecules. Blood 84:2068.
30. Bevilacqua, M. P. 1993. Endothelial-leukocyte adhesion molecules. Annu. Rev. Immunol. 11:767.
31. Lasky, L. A. 1992. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 258:964.
32. Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Ross, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.
33. Offermann, M. K., J. Zimring, K. H. Mellits, M. K. Hagan, R. Shaw, R. M. Medford, M. B. Mathews, S. Goodhourn, and R. Jagus. 1995. Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (1)·poly (C) in endothelial cells. Eur. J. Biochem. 232:28.
34. Bevilacqua, M. P., S. Stengelin, M. A. Gimborne, Jr., and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160.
35. Doukas, J., Cutler, A. H., and Mordes, J. P. 1994. Polyinosinic:polycytidylic acid is a potent activator of endothelial cells. Am. J. Pathol 145:137.
36. Tiwari, R. K., J. Kusari, and G. C. Sen. 1987. Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors. EMBO J. 6:3373.
37. Bandyopadhyay, S. K., G. T. Leonard Jr., T. Bandyopadhyay, G R. Stark, and G. C. Sen. 1995. Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3. J. Biol. Chem. 270:19624.
38. Daly, C., and N. C. Reich. 1993. Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element. Mol. Cell. Biol. 13:3756.
39. Wathelet, M. G., P. M. Berr, and G. A. Huez. 1992. Regulation of gene expression by cytokines and virus in human cells lacking the type-I interferon locus. Eur. J. Biochem. 206:901.
40. Sen, G. C., and R. M. Ransohoff. 1993. Interferon-induced antiviral actions and their regulation. Adv. Virus Res. 42:57.
41. Ghersa, P., R. Hooft van Huijsduijnen, J. Whelan, and J. F. DeLamarter. 1992. Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. J. Biol. Chem. 267:19226.
42. Montgomery, K. F., L. Osborn, C. Hession, R. Tizard, D. Goff, C. Vassallo, P. I. Tarr, K. Bomsztyk, R. Lobb, J. M. Harlan, and T. H. Pohlman. 1991. Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proc. Natl. Acad Sci. USA 88:6523.
43. Whelan, J., P. Ghersa, R. Hooft van Huijsduijnen, J. Gray, G. Chandra, F. Talabot, and J. F. DeLamater. 1991. An NFκB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids Res. 19:2645.
44. Schindler, U., and Baichwal, V. 1994. Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor α-induced expression. Mol. Cell. Biol. 14:5820.
45. Kaszubska, W., R. Hooft van Huijsduijnen, P. Ghersa, A. M. Schenk, B. P. C. Chen, T. Hai, J. F. DeLamater, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selectin promoter in response to cytokines. Mol. Cell. Biol. 13:7180.
46. Hooft van Huijsduijnen, R., J. Whelan, R. Pescini, A. Becker-Andre, A. M. Schenk, and J. F. DeLamater. 1992. A T-cell enhancer cooperates with NF-κB to yield cytokine induction of E-selectin gene transcription in endothelial cells. J. Biol. Chem. 267:22385.
47. Becker-Andre, M., R. Hooft van Huijsduijnen, C. Losberger, J. Whelan, and J. F. DeLamater. 1992. Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein. Eur. J. Biochem. 206:401.
48. Shankar, R., C. de La Motte, and P. DiCorleto. 1992. 3-Deazaadenosine inhibits thrombin-stimulated platelet-derived growth factor production and endothelial-leukocyte adhesion molecule-1-mediated monocytic cell adhesion in human aortic endothelial cells. J. Biol. Chem. 267:9376.
49. Faruqi, T. R., and P. E. DiCorleto. 1997. IFN-γ inhibits double-stranded RNA-induced E-selectin expression in human endothelial cells. J. Immunol. 159:3989.
50. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. Transfection by electroporation. Current Protocols in Molecular Biology, Vol. 1.
51. Haque, S. J., and B. R. G. Williams. 1994. Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-α. J. Biol. Chem. 269:19523.
52. Shuai, K., C. Schindler, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808.
53. Yang, J., Y. Xu, C. Zhu, M. Hagan, T. Lawley, and M. K. Offermann. 1994. Regulation of adhesion molecule expression in Kaposi's sarcoma cells. J. Immunol. 152:361.
54. De Luca, L. G., D. R. Johnson, M. Z. Whitley, T. Collins, and J. S. Pober. 1994. cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter J. Biol. Chem. 269:19193.
55. Collins, T., M. A. Read, A. S. Neish, M. Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9:899.
56. Whitley, M. Z., D. Thanos, M. A. Read, T. Maniatis, and T. Collins. 1994. A striking similarity in the organization of the E-selectin and β interferon gene promoters. Mol. Cell. Biol. 14:6464.
57. Lewis, H., W. Kaszubska, J. Delarmeter, and J. Whelan. 1994. Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol. Cell. Biol. 9:5701.
58. Thanos, D., and T Maniatis. 1992. The high mobility group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene. Cell 71:777.
59. Thanos, D., and T Maniatis. 1995. Virus induction of human IFN β gene expression requires the assembly of an enhanceosome. Cell 83:1091.
60. Falvo, J. V., D. Thanos, and T Maniatis. 1995. Reversal of intrinsic DNA bends in the IFN β gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell 83:1101.
61. DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548.
62. Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373.
63. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
64. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goddet. 1997. IGKB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
65. Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
66. May, M. J., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19:80.
67. Suyang, H., R. Phillips, I. Douglas, and S. Ghosh. 1996. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol. Cell. Biol. 16:5444.
68. Cheshire, J. L., B. R. G. Williams, and A. S. Baldwin, Jr. 1999. Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-κB by tumor necrosis factor-α and γ-interferon in preneuronal cells. J. Biol. Chem. 274:4801.
69. Gonostajski, R. M. 1986. Analysis of nuclear factor I binding to DNA using degenerate oligonucleotides. Nucleic Acids Res. 14:9117.
70. Daryoush, M. Z., T. H. Mogensen, J. A. DiDonator, and B. R. G. Williams. 2000. NF-κB activation by the dsRNA-activated protein kinase (PKR) is mediated through NF-κB-inducing kinase and IκB kinase. Mol. Cell. Biol. In press.