Telomerase and mammalian ageing: A critical appraisal

Mechanisms of Ageing and Development

Volumn 114, Issue 2, 2000, Pages 69-77

  Goyns, Malcolm H ^a   Lavery, W Lindsay ^a  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Ageing; Cancer; Telomerase; Telomere

Indexed keywords

TELOMERASE;

AGING; CELL CULTURE; CELL TRANSFORMATION; CELL TYPE; ENZYME ACTIVITY; FIBROBLAST; HUMAN; IN VITRO STUDY; KNOCKOUT MOUSE; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENESCENCE; TELOMERE; TUMOR CELL;

AGING; ANIMALS; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MAMMALS; MICE; TELOMERASE;

ANIMALIA; MAMMALIA;

EID: 0034643116     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00095-6     Document Type: Review

References (62)

1. Allsop R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA. 89:1992;10114-10118.
2. Ashcroft G.S., Horan M.A., Ferguson M.W.J. The effects of ageing in cutaneous wound healing in mammals. J. Anat. 187:1995;1-26.
3. Bierman E.L. The effect of donor age on the in vitro lifespan of cultured human arterial smooth muscle cells. In Vitro. 14:1978;951-955.
4. Blackburn E.H. Structure and function of telomeres. Nature. 350:1991;569-573.
5. Blackburn E.H. Telomerases. Ann. Rev. Biochem. 61:1992;113-129.
6. Blackburn E.H., Szostak J.W. The molecular structure of centromeres and telomeres. Ann. Rev. Biochem. 53:1984;163-194.
7. Blasco M.A., Lee H.E., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., Greider C.W. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:1997;25-34.
8. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright E.W. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:1998;349-352.
9. Broccoli D., Young J.W., de Lang T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA. 93:1995;9082-9085.
10. Buchkovich K.J., Greider M.A. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Cell. Biol. 7:1996;1443-1454.
11. Campisi J. The biology of replicative senescence. Eur. J. Cancer. 33:1997;703-709.
12. Charlton A.M., Merry B.J., Goyns M.H. Differential display analysis reveals patterns of gene expression in immortalised hepatoma cells which are characteristic of young adult but not old adult liver. Cancer Lett. 143:1999;45-50.
13. Chiu C.P., Dragowska W., Kim N.W., Vaziri H., Yui J., Thomas T.E., Harley C.B., Lansdorp P.M. Telomerase expression in human cells and tissues. Aging Clin. Exp. Res. 7:1995;460-461.
14. Chiu C.P., Dragowska W., Kim N.W. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells. 14:1996;239-248.
15. Counter C.M., Avilion A.A., LeFeuvre C.E., Stewart N.G., Geider C.W., Harley C.B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
16. Counter C.M., Bothelo F.M., Wang P., Harley C.B., Bacchetti S. Stabilisation of short telomeres and telomerase activity accompany immortalisation of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68:1994;3410-3414.
17. Counter C.M., Hirte H.W., Bacchetti S., Harley C.B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA. 91:1994b;2900-2903.
18. Counter C.M., Gupta J., Harley C.B., Leber B., Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood. 85:1995;2315-2320.
19. De Lange T., Shiue L., Myers R.M., Cox D.R., Naylor S.L., Killery A.M., Varmus H.E. Structure and variability of human chromosome ends. Mol. Cell. Biol. 10:1990;518-527.
20. Dice J.F. Cellular and molecular mechanism of aging. Physiol. Rev. 73:1993;149-159.
21. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., Peacocke M., Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA. 92:1995;9363-9367.
22. Goyns M.H., Charlton M.A., Dunford J.E., Lavery W.L., Merry B.J., Salehi M., Simoes D.C.M. Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes. Mech. Ageing Dev. 101:1998;73-90.
23. Greaves M. Is telomerase activity in cancer due to selection of stem cells and differentiation arrest? Trends Genet. 12:1996;127-128.
24. Greider C.W. Telomeres, telomerase and senescence. Bioessays. 12:1990;363-369.
25. Greider C.W. Telomere length regulation. Ann. Rev. Biochem. 65:1996;337-365.
26. Greider C., Blackburn E.H. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell. 43:1985;405-413.
27. Greider C., Blackburn E.H. A telomeric sequence in the RNA of tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:1989;331-337.
28. Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature. 400:1999;464-468.
29. Harle-Bacher C., Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. USA. 93:1996;6476-6481.
30. Harley C.B., Villeponteau B. Telomeres and telomerase in aging and cancer. Curr. Opin. Genet. Dev. 5:1995;249-255.
31. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
32. Hastie N.D., Dempster M., Dunlop M.G., Thompson A.M., Green D.K., Allshire R.C. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:1990;868-886.
33. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
34. Hayflick L. Theories of biological aging. Exp. Gerontol. 20:1985;145-159.
35. Hiyama K., Hirai Y., Kyiozumi S., Akiyama M., Hiyama E., Piatyszek M.A., Shay J.W., Ishioka S., Yamakido M. Telomerase activity in human peripheral blood and bone marrow cells. J. Immunol. 155:1995;3711-3715.
36. Hook E.B. Rates of chromosomal abnormalities at different maternal ages. Obstet. Gynecol. 58:1981;282-285.
37. Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L., Coviello G.M., Wright W.E., Weinrich S.L., Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science. 226:1994;2011-2015.
38. Kipling D. Telomere structure and telomerase expression during mouse development and tumorigenesis. Eur. J. Cancer. 33:1997;792-800.
39. Kipling D., Cooke H.J. Hypervariable ultra-long telomeres in mice. Nature. 347:1990;400-402.
40. Kipling D., Faragher R.G.A. Ageing hard or hardly ageing? Nature. 398:1999;191-193.
41. Krishna D.R., Sperker B., Fritz P., Klotz U. Does pH 6 beta-galactosidase activity indicate cell senescence? Mech. Ageing Dev. 109:1999;113-123.
42. Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W., Greider C.W., DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574.
43. Levy M.Z., Allsopp R.C., Futcher A.B., Greider C.W., Harley C.B. Telomere end-replication problem and cell aging. J. Mol. Biol. 225:1992;951-960.
44. Linskens M.H.K., Feng J., Andrews W.H., Enloe B.E., Saati S.M., Tonkin L.A., Funk W.D., Villepontoau B. Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Res. 23:1995;3244-3251.
45. Marcand S., Buck S.W., Moretti P., Gilson E., Shore D. Silencing of genes at non-telomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes Dev. 10:1996;1297-1309.
46. Meyne J., Ratliff R., Moyzis R. Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proc. Natl. Acad. Sci. USA. 86:1989;7049-7052.
47. Millis A.J., Sottile J., Hoyle M., Mann D.M., Diemer V. Collagenase production by early and late passage cultures of human fibroblasts. Exp. Gerontol. 24:1989;559-757.
48. Mizuno M., Packer L. Suppression of the proto-oncogene c-fos expression by antioxidant dihydrolipoic acid. Methods Enzymol. 252:1995;108-186.
49. Olovnikov A.M. A theory of mariginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41:1973;181-190.
50. Rhome D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc. Natl. Acad. Sci USA. 78:1981;5009-5013.
51. Rudolph K.L., Chang S., Lee H.W., Blasco M., Gottlieb G.J., Greider C., DePinto R.A. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:1999;701-712.
52. Salehi M., Hodgkins M., Merry B., Goyns M.H. Age-related changes in gene expression identified in the rat brain by differential display. Experientia. 52:1996;888-891.
53. Salehi M., Barron M.J., Merry B.J., Goyns M.H. Fluorescence in-situ hybridization analysis of the fos/jun ratio in the ageing brain. Mech. Ageing Dev. 107:1999;61-71.
54. Salk D., Bryant E., Hoehn H., Johnston P., Martin G.M. Growth characteristics of Werner syndrome cells in vitro. Adv. Exp. Med. Biol. 190:1985;305-311.
55. Schnieder E.L., Mitsui Y. The relationship between in vitro cellular aging and in vivo human aging. Proc. Natl. Acad. Sci. USA. 73:1976;3584-3588.
56. Shay J.W., Wright W.E. Defining the molecular mechanisms of human cell immortalisation. Biochim. Biophys. Acta. 1071:1991;1-7.
57. Shibanuma M., Kuroki T., Nose K. Induction of DNA replication and expression of proto-oncogene cis-myc and cis-fos in quiescent BALB/3T3 cells by xanthine-oxidase. Oncogene. 3:1988;17-21.
58. Starling J.A., Maule J., Hastie N.D., Allshire R.C. Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res. 18:1990;6881-6888.
59. Timiras P.S. Degernerative changes in cells and cell death. Timiras P.S. Physiological Basis of Aging and Geriatrics. second ed:1994;47-59 CRC Press, Boca Raton, FL.
60. Weitzman J.B., Yaniv M. Rebuilding the road to cancer. Nature. 400:1999;401-402.
61. Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., Shay J.W. Telomerase activity in germline and embryonic tissues. Dev. Genet. 18:1996;173-179.
62. Yegorov Y.E., Akimov S.S., Hass R., Zelenin A.V., Pruovsky I.A. Endogenous β-galactosidase activity in continuously non-proliferating cells. Exp. Cell Res. 243:1998;207-211.