Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice

Mechanisms of Ageing and Development

Volumn 114, Issue 2, 2000, Pages 101-121

  Lau, Lisa L ^a,b   Spain, Lisa M ^a  

^a WISTAR INSTITUTE   (United States)

^b HOLLAND LABORATORY   (United States)

Author keywords

Aging; Knock out; T cell receptors; Thymus; Transgenic

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

AGED; AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INVOLUTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THYMUS FUNCTION; TRANSGENIC MOUSE;

AGING; ALLELES; ANIMALS; ANTIGENS, CD4; BETA 2-MICROGLOBULIN; DOWN-REGULATION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SIZE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND; TRANSGENES;

EID: 0034642966     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00091-9     Document Type: Article

References (59)

1. Adkins B., Tidmarsh G.F., Weissman I.L. Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen. Immunogen. 27:1988;180-186.
2. Aspinall R. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158:1997;3037-3045.
3. Balomenos D., Balderas R.S., Mulvany K.P., Kaye J., Kono D.H., Theofilopoulos A.N. Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells. J. Immunol. 155:1995;3308-3312.
4. Bellamy D., Hinsull S.M., Phillips J.G. Factors controlling growth and age involution of the rat thymus. Age. Ageing. 5:1976;12-19.
5. Berg L.J., Fazekas de St. Groth B., Pullen A.M., Davis M.M. Phenotypic differences between alpha beta and beta T cell receptor transgenic mice undergoing negative selection. Nature. 340:1989;559-562.
6. Berg L.J., Pullen A.M., Fazekas de St. Groth B., Mathis D., Benoist C., Davis M.M. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 58:1989;1035-1046.
7. Bodey B., Bodey B. Jr., Siegel S.E., Kaiser H.E. Involution of the mammalian thymus, one of the leading regulators of aging. In Vivo. 11:1997;421-440.
8. Brabb T., Huseby E.S., Morgan T.M., Sant'Angelo D.B., Kirchner J., Farr A.G., Goverman J. Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions. Eur. J. Immunol. 27:1997;136-146.
9. Brown D.R., Moskowitz N.H., Killeen N., Reiner S.L. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186:1997;101-107.
10. Burkly L., Hession C., Ogata L., Reilly C., Marconi L.A., Olson D., Tizard R., Cate R., Lo D. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 373:1995;531-536.
11. Crisi G.M., Tsiagbe V.K., Russo C., Basch R.S., Thorbecke G.J. Evaluation of presence and functional activity of potentially self-reactive T cells in aged mice. Int. Immunol. 8:1996;387-395.
12. Desbarats J., Lapp W.S. Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions. J. Exp. Med. 178:1993;805-814.
13. Doucek D.C., McFarland R.D., Keiser P.H. et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:1998;690-695.
14. Dubiski S., Ponnappan U., Cinader B. Strain polymorphism in progression of aging: changes in CD4, CD8 bearing subpopulations. Immunol. Lett. 23:1989;1-7.
15. Eren R., Zharhary D., Abel L., Globerson A. Age-related changes in the capacity of bone marrow cells to differentiate in thymic organ cultures. Cell. Immunol. 112:1988;449-455.
16. Farr A.G., Anderson S.K. Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J. Immunol. 134:1985;2971-2977.
17. Farr A.G., Sidman C.L. Reduced expression of Ia antigens by thymic epithelial cells of aged mice. J. Immunol. 133:1984;98-103.
18. Fowell D.J., Magram J., Turck C.W., Killeen N., Locksley R.M. Impaired Th2 subset development in the absence of CD4. Immunity. 6:1997;559-569.
19. Fridkis-Hareli M., Abel L., Globerson A. Patterns of dual lymphocyte development in co-cultures of foetal thymus and lymphohaemopoietic cells from young and old mice. Immunology. 77:1992;185-188.
20. Fukushi N., Arase H., Wang B., Ogasawara K., Gotohda T., Good R.A., Onoe K. Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance. Proc. Natl. Acad. Sci. USA. 87:1990;6301-6305.
21. George A.J., Ritter M.A. Thymic involution with ageing: obsolescence or good housekeeping? Immunol. Today. 17:1996;267-272.
22. Godfrey D.I., Kennedy J., Mombaerts P., Tonegawa S., Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. J. Immunol. 152:1994;4783-4792.
23. Godfrey D.I., Zlotnik A. Control points in early T-cell development. Immunol. Today. 14:1993;547-553.
24. Gonzalez-Quintial R., Baccala R., Balderas R.S., Theofilopoulos A.N. V beta gene repertoire in the aging mouse: a developmental perspective. Int. Rev. Immunol. 12:1995;27-40.
25. Gonzalez-Quintial R., Theofilopoulos A.N. V beta gene repertoires in aging mice. J. Immunol. 149:1992;230-236.
26. Hartwig M. Immune control of mammalian aging: a T-cell model. Mech. Ageing Dev. 63:1992;207-213.
27. Hartwig M., Steinmann G. On a causal mechanism of chronic thymic involution in man. Mech. Ageing Dev. 75:1994;151-156.
28. Hirokawa K., Kubo S., Utsuyama M., Kurashima C., Sado T. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell. Immunol. 100:1986;443-451.
29. Hollander G.A., Widmer B., Burakoff S.J. Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease. J. Immunol. 152:1994;1609-1617.
30. Jackson A.U., Fornes A., Galecki A., Miller R.A., Burke D.T. Multiple-trait quantitative trait loci analysis using a large mouse sibship. Genetics. 151:1999;785-795.
31. Kuro-o M., Matsumura Y., Aizawa H. et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 390:1997;45-51.
32. Law Y.M., Yeung R.S., Mamalaki C., Kioussis D., Mak T.W., Flavell R.A. Human CD4 restores normal T cell development and function in mice deficient in murine CD4. J. Exp. Med. 179:1994;1233-1242.
33. Lin Q., Taniuchi I., Kitamura D., Wang J., Kearney J.F., Watanabe T., Cooper M.D. T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J. Immunol. 160:1998;4681-4687.
34. Linton P.J., Haynes L., Klinman N.R., Swain S.L. Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184:1996;1891-1900.
35. Locksley R.M., Reiner S.L., Hatam F., Littman D.R., Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science. 261:1993;1448-1451.
36. Mackall C.L., Granger L., Sheard M.A., Cepeda R., Gress R.E. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood. 82:1993;2585-2594.
37. Mackall C.L., Punt J.A., Morgan P., Farr A.G., Gress R.E. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28:1998;1886-1893.
38. Matechak E.O., Killeen N., Hedrick S.M., Fowlkes B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:1996;337-347.
39. McCarrick J.W.D., Parnes J.R., Seong R.H., Solter D., Knowles B.B. Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells. Trans. Res. 2:1993;183-190.
40. Miller R.A. Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice. Mech. Ageing Dev. 96:1997;181-196.
41. Miller R.A., Bookstein F., Van der Meulen J., Engle S., Kim J., Mullins L., Faulkner J. Candidate biomarkers of aging: age-sensitive indices of immune and muscle function covary in genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 52:1997;B39-B47.
42. Miller R.A., Burke D., Nadon N. Announcement: four-way cross mouse stocks: a new, genetically heterogeneous resource for aging research. J. Gerontol. A Biol. Sci. Med. Sci. 54:1999;B358-360.
43. Miller R.A., Chrisp C., Galecki A. CD4 memory T cell levels predict life span in genetically heterogeneous mice. FASEB J. 11:1997;775-783.
44. Nabarra B., Andrianarison I. Ultrastructural study of thymic microenvironment involution in aging mice. Exp. Gerontol. 31:1996;489-506.
45. Nabarra B., Casanova M., Paris D., Paly E., Toyoma K., Ceballos I., London J. Premature thymic involution, observed at the ultrastructural level, in two lineages of human-SOD-1 transgenic mice. Mech. Ageing Dev. 96:1997;59-73.
46. Rahemtulla A., Kundig T.M., Narendran A., Bachmann M.F., Julius M., Paige C.J., Ohashi P.S., Zinkernagel R.M., Mak T.W. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur. J. Immunol. 24:1994;2213-2218.
47. Sarukhan A., Garcia C., Lanoue A., von Boehmer H. Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity. 8:1998;563-570.
48. Seddik M., Seemayer T.A., Lapp W.S. T cell functional defect associated with thymid epithelial cell injury induced by a graft-versus-host reaction. Transplantation. 29:1980;61-66.
49. Seemayer T.A., Lapp W.S., Bolande R.P. Thymic involution in murine graft-versus-host reaction. Epithelial injury mimicking human thymic dysplasia. Am. J. Pathol. 88:1977;119-133.
50. Sharp A., Kukulansky T., Globerson A. In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors. Eur. J. Immunol. 20:1990;2541-2546.
51. Simpson J.G., Gray E.S., Beck J.S. Age involution in the normal human adult thymus. Clin. Exp. Immunol. 19:1975;261-265.
52. Smith G.S., Walford R.L., Mickey M.R. Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids. J. Natl. Cancer Inst. 50:1973;1195-1213.
53. Staerz U.D., Pasternack M.S., Klein J.R., Benedetto J.D., Bevan M.J. Monoclonal antibodies specific for a murine cytotoxic T-lymphocyte clone. Proc. Natl. Acad. Sci. USA. 81:1984;1799-1803.
54. Takeda T., Hosokawa M., Takeshita S. et al. A new murine model of accelerated senescence. Mech. Ageing Dev. 17:1981;183-194.
55. Thoman M.L. The pattern of T lymphocyte differentiation is altered during thymic involution. Mech. Ageing Dev. 82:1995;155-170.
56. Thoman M.L. Early steps in T cell development are affected by aging. Cell. Immunol. 178:1997;117-123.
57. Thoman M.T. Effects of the aged microenvironment on CD4+ T cell maturation. Mech. Age. Devel. 96:1997;75-88.
58. von Herrath M.G., Yokoyama M., Dockter J., Oldstone M.B., Whitton J.L. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J. Virol. 70:1996;1072-1079.
59. Zal T., Weiss S., Mellor A., Stockinger B. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA. 93:1996;9102-9107.