Connexin40, bundle-branch block, and propagation at the purkinje-myocyte junction

Circulation Research

Volumn 87, Issue 10, 2000, Pages 835-836

  Saffitz, Jeffrey E ^a,b   Schuessler, Richard B ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Connexin40; Knockout mice; Optical mapping

Indexed keywords

CONNEXIN 40; GENE PRODUCT; LIDOCAINE; GAP JUNCTION PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARRHYTHMOGENESIS; BRUGADA SYNDROME; EDITORIAL; ELECTROCARDIOGRAM; GENE MUTATION; HEART ARRHYTHMIA; HEART LEFT BUNDLE BRANCH BLOCK; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART RIGHT BUNDLE BRANCH BLOCK; HIS BUNDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL JUNCTION; CYTOLOGY; GENETICS; HEART BUNDLE BRANCH BLOCK; HEART CONTRACTION; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; HUMAN; METABOLISM; MOUSE MUTANT; NOTE; PURKINJE FIBER;

ANIMALS; BUNDLE-BRANCH BLOCK; CONNEXINS; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HUMANS; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIUM; PURKINJE FIBERS;

EID: 0034634089     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.10.835     Document Type: Editorial

References (12)

1. High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system
2. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
3. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
4. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation
5. Characteristics and prognosis of incomplete right bundle branch block: An epidemiologic study
6. Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V1 and V3 and sudden death
7. 6) expression delineates an extended conduction system in the embryonic and mature rodent heart
8. The gap junction communication channel
9. Interaction of transmembrane potentials in canine Purkinje fibers and at Purkinje fibermuscle junctions
10. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling
11. Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice
12. Interdependence of modulated dispersion and tissue structure in the mechanism of unidirectional block