Backbone dynamics of the C-terminal SH2 domain of the p85α subunit of phosphoinositide 3-kinase: Effect of phosphotyrosine-peptide binding and characterization of slow conformational exchange processes

Journal of Molecular Biology

Volumn 299, Issue 3, 2000, Pages 771-788

  Kristensen, Søren M ^a   Siegal, Gregg ^b   Sankar, Andrew ^c   Driscoll, Paul C ^c,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LEIDEN UNIVERSITY   (Netherlands)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

15N relaxation; Conformational exchange; Nuclear magnetic resonance; P85 ; Phosphotyrosine peptide binding

Indexed keywords

ALANINE; ASPARAGINE; CYSTEINE; GLUCOSE; NITROGEN 15; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE P60; PROTEIN P85; TYROSINE;

ARTICLE; BINDING KINETICS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

RNA VIRUSES;

EID: 0034625316     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3760     Document Type: Article

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