Crystal structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase: An SH2 domain mimicking its own substrate

Journal of Molecular Biology

Volumn 292, Issue 4, 1999, Pages 763-770

  Hoedemaeker, Flip J ^a   Siegal, Gregg ^a   Roe, S Mark ^b,c   Driscoll, Paul C ^b,c   Abrahams, Jan Pieter ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Inhibitor; Phosphotyrosine mimic; PI3K; SH2; Structure aided design

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBUNIT; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0033214182     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3111     Document Type: Article

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