Synthesis and biological evaluation of fully synthetic bryostatin analogues

Tetrahedron Letters

Volumn 39, Issue 47, 1998, Pages 8625-8628

  Wender, Paul A ^b   De Brabander, Jef ^b   Harran, Patrick G ^b   Hinkle, Kevin W ^b   Lippa, Blaise ^b   Pettit, George R ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN; PROTEIN KINASE C;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CHEMOTHERAPY; CANCER INHIBITION; CLINICAL TRIAL; DRUG ISOLATION; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; PHASE 2 CLINICAL TRIAL;

EID: 0032547979     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01955-8     Document Type: Article

References (15)

1. [1] Pettit, G. R.; Herald, C. L.; Doubek, D. L.; Herald, D. L.; Arnold, E.; Clardy, J. J. Am. Chem. Soc. 1982, 104, 6846-6848.
2. [2] Pettit, G. R. J. Nat. Prod. 1996, 59, 812-821.
3. [3] Current information on the scope and status of bryostatin clinical trials can be found on the NCI web page at: http://cancernet.nci.nih.gov/prot/patsrch.shtml
4. [4] Kraft, A. S.; Smith, J. B.; Berkow, R. L. Proc. Natl. Acad. Sci. USA 1986, 83, 1334-1338.
5. [5] Berkow, R. L.; Kraft, A. S. Biochem. Biophys, Res. Commun. 1985, 131, 1109-1116.
6. [6] Ramsdell, J. S.; Pettit, G. R.; Tashjian Jr., A. H. J. Biol. Chem. 1986, 261, 7073-7080.
7. [7] Wender, P. A.; Cribbs, C. M.; Koehler, K. F.; Sharkey, N. A.; Herald, C. L.; Kamano, Y.; Pettit, G. R.; Blumberg, P. M. Proc. Natl. Acad. Sci. USA 1988, 85, 7197-7201.
8. [8] Kraft, A. S.; Woodley, S.; Pettit, G. R.; Gao, F.; Coll, J. C.; Wagner, F. Cancer Chemother. Pharmacol. 1996, 37, 271-278.
9. [9] Szallasi, Z.; Du, L.; Levine, R.; Lewin, N. E.; Nguyen, P. N.; Williams, M. D.; Pettit, G. R.; Blumberg, P. M. Cancer Res. 1996, 56, 2105-2111 and references cited therein.
10. [10] Wender, P. A.; De Brabander, J.; Harran, P. G.; Jimenez, J-M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Shiozaki, M.; Pettit, G. R. J. Am. Chem. Soc. 1998, 120, 4534-4535.
11. [11] Wender, P. A.; De Brabander, J.; Harran, P. G.; Jimenez, J-M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Siedenbiedel, C.; Pettit, G. R. Proc. Natl. Acad. Sci. USA 1998, 55, 6624-6631.
12. [12] Harada, T.; Shintani, T.; Oku, A. J. Am. Chem. Soc. 1995, 117, 12346-12347.
13. [13] Dess, D. B.; Martin, J. C. J. Am. Chem. Soc. 1991, 113, 7277-7287.
14. [14] Brown, H. C.; Jadhav, P. K. J. Am. Chem. Soc. 1983, 105, 2092-2093.
15. [15] Inanaga, J.; Hirata, K.; Saeki, H.; Katsuki, T.; Yamaguchi, M. Bull. Chem. Soc. Jpn. 1979, 52, 1989-1993.