Novel conformationally constrained analogues of diacylglycerol. Protein kinase C binding affinity of simplified compounds based on a 6-membered lactam moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 23, 1997, Pages 2997-3000

  Endo, Yasuyuki ^a   Hirano, Masaaki ^a   Driedger, Paul E ^b   Stabel, Silvia ^c   Shudo, Koichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Procyon Pharmaceuticals Inc   (United States)

^c Max Delbruck Laboratorium der Max Planck Gesellschaft   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMETHYL 3 ISOPROPYL 4 TETRADECYLPIPERAZIN 2 ONE; DIACYLGLYCEROL; INDOLACTAM V; PHORBOL DIBUTYRATE; PIPERAZINE DERIVATIVE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HL 60; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR PROMOTION;

EID: 0030661842     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10129-9     Document Type: Article

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