Crystal structures of a marginally active thymidylate synthase mutant, Arg 126 → Glu

Protein Science

Volumn 6, Issue 12, 1997, Pages 2504-2511

  Strop, Pavel ^a   Changchien, Liming ^b   Maley, Frank ^b   Montfort, William R ^a  

^a University of Arizona   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

Enzyme mechanism; Inhibitor; Mutation; X ray crystallography

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; ARGININE; BACTERIAL ENZYME; CYSTEINE; DEOXYURIDINE PHOSPHATE; GLUTAMIC ACID; METHYLENETETRAHYDROFOLIC ACID; MUTANT PROTEIN; PHOSPHATE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0031452278     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560061203     Document Type: Article

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