Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs

Gene

Volumn 230, Issue 2, 1999, Pages 233-239

  Ichinose, Hiroshi ^a   Ohye, Tamae ^a   Suzuki, Takahiro ^a   Sumi Ichinose, Chiho ^b   Nomura, Takahide ^b   Hagino, Yasumichi ^b   Nagatsu, Toshiharu ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cDNA; Dopamine; Exons; Introns; Orphan receptors; Parkinson's disease; Schizophrenia

Indexed keywords

CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; TRANSCRIPTION FACTOR;

ARTICLE; DNA FLANKING REGION; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE SEQUENCE; HUMAN; MOLECULAR CLONING; NERVE CELL DIFFERENTIATION; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ALTERNATIVE SPLICING; BASE SEQUENCE; BINDING SITES; BRAIN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EXONS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PARKINSON DISEASE; RESTRICTION MAPPING; SCHIZOPHRENIA; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION FACTORS;

EID: 0033574750     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(99)00065-7     Document Type: Article

References (16)

1. Aschauer H.N., Fischer G., Isenberg K.E., Meszaros K., Willinger U., Todd R.D., Beran H., Strobl R., Lang M., Fuchs K., et al. No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region. Eur. Arch. Psychiatry Clin. Neurosci. 243:1993;193-198.
2. Breathnach R., Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50:1981;349-383.
3. Castillo S.O., Xiao Q., Lyu M.S., Kozak C.A., Nikodem V.M. Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene. Genomics. 41:1997;250-257.
4. Goodman A.B. Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc. Natl. Acad. Sci. USA. 95:1998;7240-7244.
5. Hazel T.G., Nathans D., Lau L.F. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA. 85:1988;8444-8448.
6. Law S.W., Conneely O.M., DeMayo F.J., O'Malley B.W. Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol. 6:1992;2129-2135.
7. Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A. NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol. Endocrinol. 8:1994;1583-1591.
8. Milbrandt J. Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron. 1:1988;183-188.
9. Nagatsu T., Levitt M., Udenfriend S. Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J. Biol. Chem. 239:1964;2910-2917.
10. Ohkura N., Hijikuro M., Yamamoto A., Miki K. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem. Biophys. Res. Commun. 205:1994;1959-1965.
11. Pena de Ortiz S., Jamieson G.A. Jr. HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures. Mol. Brain Res. 38:1996;1-13.
12. Perlmann T., Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 9:1995;769-782.
13. Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., De Mayo F., Burbach J.P., Conneely O.M. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA. 95:1998;4013-4018.
14. Scearce L.M., Laz T.M., Hazel T.G., Lau L.F., Taub R. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J. Biol. Chem. 268:1993;8855-8861.
15. Zetterstrom R.H., Williams R., Perlmann T., Olson L. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol. Brain Res. 41:1996;111-120.
16. Zetterstrom R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:1997;248-250.