Molecular determinants of site-specific inhibition of human DNA topoisomerase I by fagaronine and ethoxidine. Relation to DNA binding

Journal of Biological Chemistry

Volumn 275, Issue 5, 2000, Pages 3501-3509

  Fleury, Fabrice ^a   Sukhanova, Alyona ^a   Ianoul, Anatoli ^a   Devy, Jerome ^a   Kudelina, Irina ^a,b   Duval, Olivier ^a,c   Alix, Alain J P ^a   Jardillier, Jean Claude ^a   Nabiev, Igor ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^c UNIVERSITÉ D'ANGERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; FAGARONINE; NSC 157995; PHENANTHRENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; DNA BINDING; DNA CLEAVAGE; DNA SEQUENCE; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; INTERCALATION COMPLEX; NONHUMAN; PRIORITY JOURNAL;

ALKALOIDS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; PHENANTHRIDINES; SUBSTRATE SPECIFICITY;

EID: 0034603084     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.5.3501     Document Type: Article

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