Investigation on process parameters involved in preparation of poly-DL-lactide-poly(ethylene glycol) microspheres containing Leptospira Interrogans antigens

International Journal of Pharmaceutics

Volumn 178, Issue 2, 1999, Pages 245-255

  Li, Xiaohong ^a   Deng, Xianmo ^a   Yuan, Minglong ^a   Xiong, Chengdong ^a   Huang, Zhitang ^b   Zhang, Yanhua ^c   Jia, Wenxiang ^c  

^a CHENGDU INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b INSTITUTE OF CHEMISTRY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Encapsulation efficiency; in vitro release; Outer membrane protein; Poly DL lactide poly(ethylene glycol); Preparative parameter

Indexed keywords

ANTIGEN; COPOLYMER; MACROGOL; MICROSPHERE; POLYGLACTIN;

ARTICLE; DRUG RELEASE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCANNING ELECTRON MICROSCOPY;

ANTIGENS, BACTERIAL; CELL MEMBRANE; DRUG INTERACTIONS; ETHYLENE GLYCOL; LEPTOSPIRA INTERROGANS; MICROSPHERES; PARTICLE SIZE; POLYMERS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TIN COMPOUNDS;

EID: 0032992355     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00379-2     Document Type: Article

References (20)

1. Alonso M.J., Cohen S., Park T.G., Gupta R.K., Siber G.R., Langer R. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharm. Res. 10:1993;945-953.
2. Bitz C., Doelker E. Influence of the preparation method on residual solvents in biodegradable microspheres. Int. J. Pharm. 131:1996;171-181.
3. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
4. Coombes A.G.A., Lavelle E.C., Jenkins P.G., Davis S.S. Single dose, polymeric, microparticle-based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen. Vaccine. 14:1996;1429-1438.
5. Deng, X.M., Li, X.H., Yuan, M.L., Xiong, C.D., Huang, Z.T., Jia, W.X., Zhang, Y.H., 1998. Optimization of preparative conditions for poly-DL-lactide-poly(ethylene glycol) microspheres with entrapped Vibrio Cholera antigens. J. Control. Rel. (in press).
6. Deng X.M., Xiong C.D., Cheng L.M. Synthesis and characterization of block copolymer from lactide and polyethylene glycol. J. Polym. Sci., Polym. Lett. 28:1990;411-416.
7. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues. 1. Orally administered biodegradable microspheres target the paper's patches. J. Control. Rel. 11:1990;205-214.
8. Eldridge J.H., Staaas J.K., Meulbroek J.A., McGhee J.R., Tice T.R., Gilley R.M. Biodegradable microspheres as a vaccine delivery system. Mol. Immunol. 28:1991;287-294.
9. Jeffery H., Davis S.S., O'Hagan D.T. The entrapment of a model protein using a water-in-oil-in-water emulsion solvent evaporation technique. Pharm. Res. 10:1993;362-368.
10. Jeffrey L., Cleland L.B., Phillip W.B., Ann D., Tim G., Amy L., Joann V., Terri W., Michael F.P. Development of a single-shot subunit vaccine for HIV-1. 2. Defining optimal autoboost characteristics to maximize the humoral immune response. J. Pharm. Sci. 85:1996;1346-1349.
11. Kenley R.A., Lee M.O., Mahoney T.R., Sanders L.M. Poly(lactide-co-glycolide) decomposition kinetics in vivo and in vitro. Macromolecules. 20:1987;2398-2403.
12. Li, X.H., Yuan, M.L., Xiong, C.D., Deng, X.M., Huang, Z.T., 1998. Preparation of poly-DL-lactide-poly(ethylene glycol) microspheres encapsulating human serum albumin. Acta Polym. Sin. (in press).
13. Li X.W., Xiao J., Deng X.M., Li X.Y., Wang H.L., Jia W.X., Zhang W.B., Men L., Yang Y., Zheng Z.X. Preparation of biodegradable polymer microspheres encapsulating protein with micro size. J. Appl. Polym. Sci. 66:1997;583-590.
14. Ogawa Y., Yamamoto M., Okada H., Yashiki T., Shimamoto T. A new technique to efficiently entrap leuprolide acetate into microencapsules of polylactide acid or copoly(lactide/glycolide) acid. Chem. Pharm. Bull. 36:1988;1095-1103.
15. O'Hagan D.T., Rahman D., McGee J.P., Jeffery H., Davis M.C., Williams P., Davis S.S. Biodegradable microparticles as antigen delivery system. Immunology. 73:1991;239-242.
16. Rafati H., Lavelle E.C., Coombes A.G.A., Stolnik S., Holland J., Davis S.S. The immune response to a model antigen associated with PLG microparticles prepared using different surfaces. Vaccine. 15:1997;1888-1897.
17. Tabata Y., Ikada Y. Macrophage phagcocytosis of biodegradable microspheres composed of L-lactide acid/glycolic acid homo- and copolymers. J. Biomed. Mater. Res. 22:1988;837-858.
18. Uchida T., Goto S. Particle size studies for subcutaneous delivery of poly(lactide-co-glycolide) microspheres containing ovalbum as vaccine formation. J. Pharm. Pharmacol. 47:1994;556-560.
19. Wang D.G., Zheng H., Hu Y.J., Qiu S.M. Study on biocompatibility of degradable PELA copolymer. Beijing Shengwu Yixue Gongcheng (in chinese). 14:1995;173-177.
20. Yan C.H., Rill W.L., Malli R., Hewetson J., Naseem H., Tammariello R., Kende M. Intranasal stimultion of long-lasting immunity against aerosol ricin challenge with ricin toxoid vaccine encapsulated in polymeric microspheres. Vaccine. 14:1996;1031-1038.