Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones

Molecular Diversity

Volumn 5, Issue 3, 2000, Pages 131-143

  Carbonell, Teresa ^a   Masip, Isabel ^b   Sánchez Baeza, Francisco ^b   Delgado, Mònica ^b   Araya, Eyleen ^b   Llorens, Oriol ^c   Corcho, Francesc ^c   Pérez, Juan J ^c   Pérez Payá, Enrique ^a   Messeguer, Angel ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

2,5 piperazinedione; Acetylcholinesterase; Combinatorial library; Inhibition; Molecular modeling; Multiple parallel synthesis; Selectivity; Solid phase

Indexed keywords

2,5 PIPERAZINEDIONE DERIVATIVE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; N (3,4 DIMETHOXYPHENETHYL) N' [3 (DIETHYLAMINO)PROPYL] 2,5 PIPERAZINEDIONE; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC ACTIVITY; COGNITION; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; ENZYME INHIBITION; HUMAN; IC 50; INHIBITION KINETICS; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NEUROMODULATION; PRIORITY JOURNAL; SIDE EFFECT; SIMULATION; SOLID PHASE EXTRACTION;

BINDING, COMPETITIVE; CHOLINESTERASE INHIBITORS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INHIBITORS; ERYTHROCYTES; GENE LIBRARY; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDE BIOSYNTHESIS; PEPTIDE LIBRARY; PIPERAZINES; TIME FACTORS;

EID: 0034583618     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016230600162     Document Type: Article

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