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Volumn 18, Issue 23, 2000, Pages 3952-3963

Phase I and pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYLURACIL; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID;

EID: 0034551725     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2000.18.23.3952     Document Type: Article
Times cited : (22)

References (49)
  • 1
    • 0002548405 scopus 로고    scopus 로고
    • 5-Fluorinated pyrimidines
    • Chabner BA, Longo DL (eds): Cancer Chemotherapy and Biotherapy: Principles and Practice. Philadelphia, PA, Lippincott-Raven
    • (1996) , pp. 149-210
    • Grem, J.L.1
  • 2
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3
  • 5
    • 0031431131 scopus 로고    scopus 로고
    • 5-Fluorouracil (5-FU) continuous intravenous infusion compared with bolus administration: Final results of a randomised trial in metastatic colorectal cancer
    • (1997) Eur J Cancer , vol.33 , pp. 1789-1793
    • Rougier, P.1    Paillot, B.2    LaPlanche, A.3
  • 6
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 7
    • 0023917467 scopus 로고
    • A randomized phase I and phase II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers
    • (1988) J Clin Oncol , vol.6 , pp. 1053-1058
    • Ardalan, B.1    Singh, G.2    Silberman, H.3
  • 10
    • 0030964196 scopus 로고    scopus 로고
    • Weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of advanced gastric cancers: An effective and low-toxic regimen for patients with poor general condition
    • (1997) Oncology , vol.54 , pp. 275-280
    • Hsu, C.H.1    Yeh, K.H.2    Chen, L.T.3
  • 12
    • 0345403552 scopus 로고    scopus 로고
    • Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: Results of a randomized trial in patients with advanced colorectal cancer
    • (1998) J Clin Oncol , vol.16 , pp. 418-426
    • Kohne, C.H.1    Schoffski, P.2    Wilke, H.3
  • 16
    • 0031060493 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: Allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 233-238
    • Khor, S.P.1    Amyx, H.2    Davis, S.T.3
  • 17
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.D.1    Khor, S.P.2    Adjei, A.A.3
  • 19
  • 21
  • 25
    • 0032945491 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice
    • (1999) Clin Cancer Res , vol.5 , pp. 883-889
    • Ishikawa, Y.1    Kubota, T.2    Otani, Y.3
  • 33
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, A.1    Zhang, R.2    Diasio, R.B.3
  • 34
    • 0031912432 scopus 로고    scopus 로고
    • Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: Implication for 5-fluorouracil-based chemotherapy
    • (1998) Clin Cancer Res , vol.4 , pp. 325-329
    • Lu, Z.1    Zhang, R.2    Carpenter, J.T.3
  • 35
    • 0033975358 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of oral fluorouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil
    • (2000) J Clin Oncol , vol.18 , pp. 915-926
    • Baker, S.D.1    Diasio, R.B.2    O'Reilly, S.3
  • 37
    • 0000419698 scopus 로고    scopus 로고
    • A phase II open-label study to evaluate a 28-day regimen of oral 5-fluorouracil plus 776C85 for the treatment of patients with previously untreated metastatic colorectal cancer
    • abstr 1083
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Mani, S.1    Beck, T.2    Chevlen, E.3
  • 42
    • 0031934445 scopus 로고    scopus 로고
    • Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors
    • (1998) J Clin Oncol , vol.16 , pp. 1131-1141
    • Rafi, I.1    Boddy, A.V.2    Calvete, J.A.3
  • 45
    • 0003267529 scopus 로고    scopus 로고
    • Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition: Effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
    • (1996) Biochem Pharmacol , vol.51 , pp. 1293-1301
    • Aherne, G.W.1    Hardcastle, A.2    Raynaud, F.3
  • 49
    • 0028281781 scopus 로고
    • 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.