-
1
-
-
0342952508
-
Pyrimidine and purine antimetabolites
-
J. F. Holland, E. Frei, R. C. Bast, D. L. Merten, D. W. Kufe, and R. R. Weichselbaum (eds.), Baltimore: Wiliams & Wilkins
-
Pizzorno, G., Cheng, Y. C., and Handschumacher, R. E. Pyrimidine and purine antimetabolites. In: J. F. Holland, E. Frei, R. C. Bast, D. L. Merten, D. W. Kufe, and R. R. Weichselbaum (eds.), Cancer Medicine, Ed. 4, pp. 923-948. Baltimore: Wiliams & Wilkins, 1996.
-
(1996)
Cancer Medicine, Ed. 4
, pp. 923-948
-
-
Pizzorno, G.1
Cheng, Y.C.2
Handschumacher, R.E.3
-
2
-
-
0005595182
-
Biochemical modulation. Perspectives and objectives
-
K. R. Harrap and T. A. Connors (eds.) New York: Academic Press
-
Martin, D. S. Biochemical modulation. Perspectives and objectives. In: K. R. Harrap and T. A. Connors (eds.) New Avenues in Developmental Cancer Chemotherapy, pp. 113-162. New York: Academic Press, 1987.
-
(1987)
New Avenues in Developmental Cancer Chemotherapy
, pp. 113-162
-
-
Martin, D.S.1
-
3
-
-
0025815823
-
Clinical relevance of biochemical modulation of 5-fluorouracil
-
Peters, G. J., and van Groeningen, C. J. Clinical relevance of biochemical modulation of 5-fluorouracil. Ann. Oncol., 2: 469-480, 1991.
-
(1991)
Ann. Oncol.
, vol.2
, pp. 469-480
-
-
Peters, G.J.1
Van Groeningen, C.J.2
-
4
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Piedbois, P., Buyse, M., Rustum, Y., Machover, D., Erlichman, C., Carlson, R. W., Valone, F., Labianca, R., Doroshow, J. H., and Petrelli, N. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J. Clin. Oncol., 10: 896-903, 1992.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
Piedbois, P.1
Buyse, M.2
Rustum, Y.3
Machover, D.4
Erlichman, C.5
Carlson, R.W.6
Valone, F.7
Labianca, R.8
Doroshow, J.H.9
Petrelli, N.10
-
5
-
-
0028920324
-
Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil
-
Spector, T., Cao, S., Rustum, Y. M., Harrington, J. A., and Porter, D. J. T. Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. Cancer Res., 55: 1239-1241, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1239-1241
-
-
Spector, T.1
Cao, S.2
Rustum, Y.M.3
Harrington, J.A.4
Porter, D.J.T.5
-
6
-
-
0021268296
-
Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs
-
Okeda, R., Karakama, T., Kimura, S., Toizumi, S., Mitsushima, T., and Yokoyama, Y. Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs. Acta Neuropathol., 63: 334-343, 1984.
-
(1984)
Acta Neuropathol.
, vol.63
, pp. 334-343
-
-
Okeda, R.1
Karakama, T.2
Kimura, S.3
Toizumi, S.4
Mitsushima, T.5
Yokoyama, Y.6
-
7
-
-
0025010640
-
Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites monofluoroacetic acid and α-fluoro-β-alanine
-
Okeda, R., Shibutani, M., Matsuo, T., Kuroiwa, R., Shimokawa, R., and Tajima, T. Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites monofluoroacetic acid and α-fluoro-β-alanine. Acta Neuropathol., 81: 66-73, 1990.
-
(1990)
Acta Neuropathol.
, vol.81
, pp. 66-73
-
-
Okeda, R.1
Shibutani, M.2
Matsuo, T.3
Kuroiwa, R.4
Shimokawa, R.5
Tajima, T.6
-
8
-
-
0028106211
-
5-Ethynyluracil (776C85): Protection from 5-fluorouracil-induced neurotoxicity in dogs
-
Davis, S. T., Joyner, S. S., Baccanari, D. P., and Spector, T. 5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs. Biochem. Pharmacol., 48: 233-236, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 233-236
-
-
Davis, S.T.1
Joyner, S.S.2
Baccanari, D.P.3
Spector, T.4
-
9
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine and bile
-
Heggie, D., Sommadossi, J-P., Cross, D. S., Huster, W. J., and Diasio, R. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine and bile. Cancer Res., 47: 2203-2206, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 2203-2206
-
-
Heggie, D.1
Sommadossi, J.-P.2
Cross, D.S.3
Huster, W.J.4
Diasio, R.5
-
10
-
-
0019876538
-
Purification and properties of dihydropyrimidine dehydrogenase from rat liver
-
Shiotani, T., and Weber, G. Purification and properties of dihydropyrimidine dehydrogenase from rat liver. J. Biol. Chem., 256: 219-224, 1981.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 219-224
-
-
Shiotani, T.1
Weber, G.2
-
11
-
-
0022400840
-
Enzymes of uracil catabolism in normal and neoplastic human tissues
-
Naguib, F. N. M., elKouni, M. H., and Cha, S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res., 45: 5402-5412, 1985.
-
(1985)
Cancer Res.
, vol.45
, pp. 5402-5412
-
-
Naguib, F.N.M.1
ElKouni, M.H.2
Cha, S.3
-
12
-
-
0028097137
-
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to 5-fluorouracil
-
Beck, A., Etienne, M. C., Cheradame, S., Fischel, J. L., Formento, P., Renee, N., and Milano, G. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to 5-fluorouracil. Eur. J. Cancer, 30: 1517-1522, 1994.
-
(1994)
Eur. J. Cancer
, vol.30
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Cheradame, S.3
Fischel, J.L.4
Formento, P.5
Renee, N.6
Milano, G.7
-
13
-
-
0027426408
-
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
-
Lu, Z., Zhang, R., and Diasio, R. B. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res., 53: 5433-5438, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 5433-5438
-
-
Lu, Z.1
Zhang, R.2
Diasio, R.B.3
-
14
-
-
0026701936
-
Mechanism based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
-
Porter, D. J. T., Chestnut, W. G., Merrill, B. M., and Spector, T. Mechanism based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. J. Biol. Chem., 267: 5236-5242, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 5236-5242
-
-
Porter, D.J.T.1
Chestnut, W.G.2
Merrill, B.M.3
Spector, T.4
-
15
-
-
0027489763
-
5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
-
Baccanari, D. P., Davis, S. T., Knick, V. C., and Specter, T. 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Proc. Natl. Acad. Sci. USA, 90: 11064-11068, 1993.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11064-11068
-
-
Baccanari, D.P.1
Davis, S.T.2
Knick, V.C.3
Specter, T.4
-
16
-
-
0028281781
-
5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
-
Cao, S., Rustum, Y. M., and Spector, T. 5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res., 54: 1507-1510, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 1507-1510
-
-
Cao, S.1
Rustum, Y.M.2
Spector, T.3
-
17
-
-
10544243363
-
Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
-
Baker, S. D., Khor, S. P., Adjei, A. A., Doucette, M., Spector, T., Donehower, R. C., Grochow, L. B., Sartorius, S. E., Noe, D. A., Hohneker, J. A., and Rowinsky, E. K. Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J. Clin. Oncol., 14: 3085-3096, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 3085-3096
-
-
Baker, S.D.1
Khor, S.P.2
Adjei, A.A.3
Doucette, M.4
Spector, T.5
Donehower, R.C.6
Grochow, L.B.7
Sartorius, S.E.8
Noe, D.A.9
Hohneker, J.A.10
Rowinsky, E.K.11
-
18
-
-
0027135995
-
5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
-
Spector, T., Harrington, J. A., and Porter, D. J. 5-Ethynyluracil (776C85): inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem. Pharmacol., 46: 2243-2248, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 2243-2248
-
-
Spector, T.1
Harrington, J.A.2
Porter, D.J.3
-
19
-
-
0030608756
-
19F-NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine
-
19F-NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine. Magn. Res. Med., 38: 907-916, 1997.
-
(1997)
Magn. Res. Med.
, vol.38
, pp. 907-916
-
-
Holland, S.K.1
Bergman, A.M.2
Zhao, Y.-M.3
Adams, E.R.4
Pizzorno, G.5
-
20
-
-
0025819516
-
19F NMR spectroscopy
-
19F NMR spectroscopy. Magn. Reson. Med., 19: 113-123, 1991.
-
(1991)
Magn. Reson. Med.
, vol.19
, pp. 113-123
-
-
Koutcher, J.A.1
Sawyer, R.C.2
Kornblith, A.B.3
Stolfi, R.L.4
Martin, D.S.5
Devitt, M.L.6
Cowburn, D.7
Young, C.W.8
-
21
-
-
0018390860
-
Comparison of liquid-and gas-liquid chromatographic assays of 5-fluorouracil in plasma
-
Christophidis, N., Mihaly, G., Vadja, M., and Louis, W. Comparison of liquid-and gas-liquid chromatographic assays of 5-fluorouracil in plasma. Clin. Chem., 25: 83-87, 1979.
-
(1979)
Clin. Chem.
, vol.25
, pp. 83-87
-
-
Christophidis, N.1
Mihaly, G.2
Vadja, M.3
Louis, W.4
-
22
-
-
0001056713
-
776C85: Effect on renal elimination of 5-fluorouracil and uracil in cancer patients
-
Khor, S. P., Lucas, S., Hsieh, A. Y., Schilsky, R., Burris, H., Von Hoff, D. D., and Spector, T. 776C85: effect on renal elimination of 5-fluorouracil and uracil in cancer patients. Proc. Am. Assoc. Cancer Res., 37: 371, 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 371
-
-
Khor, S.P.1
Lucas, S.2
Hsieh, A.Y.3
Schilsky, R.4
Burris, H.5
Von Hoff, D.D.6
Spector, T.7
-
23
-
-
0025043987
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics. J. Clin. Oncol., 8: 1868-1873, 1990.
-
(1990)
J. Clin. Oncol.
, vol.8
, pp. 1868-1873
-
-
Presant, C.A.1
Wolf, W.2
Albright, M.J.3
Servis, K.L.4
Ring R. III5
Atkinson, D.6
Ong, R.L.7
Wiseman, C.8
King, M.9
Blayney, D.10
Kennedy, P.11
El-Tahtawy, A.12
Singh, M.13
Shani, J.14
-
24
-
-
0025096726
-
19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits
-
19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc. Natl. Acad. Sci. USA. 87: 492-496, 1990.
-
(1990)
Proc. Natl. Acad. Sci. USA.
, vol.87
, pp. 492-496
-
-
Wolf, W.1
Presant, C.A.2
Servis, K.L.3
El-Tahtawy, A.4
Albright, M.J.5
Barker, P.B.6
Ring R. III7
Atkinson, D.8
Ong, R.9
King, M.10
Singh, M.11
Ray, M.12
Wiseman, C.13
Blayney, D.14
Shani, J.15
-
25
-
-
0030845828
-
5-Ethynyluracil (EU): Effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model
-
Arellano, M., Malet-Martino, M., Martino, R., and Spector, T. 5-Ethynyluracil (EU): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model. Br. J. Cancer, 76: 1170-1180, 1997.
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1170-1180
-
-
Arellano, M.1
Malet-Martino, M.2
Martino, R.3
Spector, T.4
-
26
-
-
0344248958
-
5-Ethynyluracil (5-EU, 776C85): Effects on thymidylate synthase (TS) inhibition and incorporation of 5-FU into RNA in mice bearing MOPC-315 tumors
-
Davis, S. T., Baccanari, D. P., and Spector, T. 5-Ethynyluracil (5-EU, 776C85): effects on thymidylate synthase (TS) inhibition and incorporation of 5-FU into RNA in mice bearing MOPC-315 tumors. Proc. Am. Assoc. Cancer Res., 36: 292, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 292
-
-
Davis, S.T.1
Baccanari, D.P.2
Spector, T.3
-
27
-
-
0028856765
-
5-Ethynyluracil (776C85): Effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil
-
Cao, S., Baccanari, D. P., Joyner, S. S., Davis, S. T., Rustum, Y. M., and Spector, T. 5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil. Cancer Res., 55: 6227-6230, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 6227-6230
-
-
Cao, S.1
Baccanari, D.P.2
Joyner, S.S.3
Davis, S.T.4
Rustum, Y.M.5
Spector, T.6
-
28
-
-
0026526790
-
Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats potential relevance to toxicity pattern of 5-fluorouracil
-
Zhang, R., Soong, S-J., Liu, T., Barnes, S., and Diasio, R. B. Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats potential relevance to toxicity pattern of 5-fluorouracil. Drug Metab. Dispos., 20: 113-119, 1992.
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 113-119
-
-
Zhang, R.1
Soong, S.-J.2
Liu, T.3
Barnes, S.4
Diasio, R.B.5
-
29
-
-
0002325189
-
Cerebellar ataxia associated with fluorinated pyrimidine therapy
-
Moertel, C. G., Reitemeier, R. J., Bolton, C. F., and Shorter, R. G. Cerebellar ataxia associated with fluorinated pyrimidine therapy. Cancer Chemother. Rep., 41: 15-18, 1964.
-
(1964)
Cancer Chemother. Rep.
, vol.41
, pp. 15-18
-
-
Moertel, C.G.1
Reitemeier, R.J.2
Bolton, C.F.3
Shorter, R.G.4
-
30
-
-
0001500798
-
Acute cerebellar syndrome secondary to 5-FU therapy
-
Riehl, J. B., and Brown, W. J. Acute cerebellar syndrome secondary to 5-FU therapy. Neurology, 14: 961-967, 1964.
-
(1964)
Neurology
, vol.14
, pp. 961-967
-
-
Riehl, J.B.1
Brown, W.J.2
-
31
-
-
0031025605
-
High-dose 5-fluorouracil infusional therapy is associated with hyperammoneamia, lactic acidosis and encephalopathy
-
Yeh, K. H., and Cheng, A. L. High-dose 5-fluorouracil infusional therapy is associated with hyperammoneamia, lactic acidosis and encephalopathy. Br. J. Cancer, 75: 464-465, 1997.
-
(1997)
Br. J. Cancer
, vol.75
, pp. 464-465
-
-
Yeh, K.H.1
Cheng, A.L.2
-
32
-
-
0031745059
-
The discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis
-
Liu, M-P., Beigelman, L., Levy, E., Handschumacher, E. R., and Pizzorno, G. The discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. Am. J. Physiol., 274: G1018-G1023, 1998.
-
(1998)
Am. J. Physiol.
, vol.274
-
-
Liu, M.-P.1
Beigelman, L.2
Levy, E.3
Handschumacher, E.R.4
Pizzorno, G.5
|