메뉴 건너뛰기




Volumn 10, Issue 2, 1998, Pages 220-225

B-cell receptor regulation of peripheral B cells

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 0031976640     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80252-5     Document Type: Article
Times cited : (49)

References (50)
  • 3
    • 0015292123 scopus 로고
    • Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissues and thoracic duct lymph of normal rats
    • Howard JC, Hunt SV, Gowans JL. Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissues and thoracic duct lymph of normal rats. J Exp Med. 135:1972;200-209.
    • (1972) J Exp Med , vol.135 , pp. 200-209
    • Howard, J.C.1    Hunt, S.V.2    Gowans, J.L.3
  • 4
    • 0017123781 scopus 로고
    • Comparative migration of T cells and B cells in the rat spleen and lymph nodes
    • Nieuwenhuis P, Ford WL. Comparative migration of T cells and B cells in the rat spleen and lymph nodes. Cell Immunol. 23:1976;254-267.
    • (1976) Cell Immunol , vol.23 , pp. 254-267
    • Nieuwenhuis, P.1    Ford, W.L.2
  • 5
    • 0027394062 scopus 로고
    • Only a small proportion of splenic B-cells in adults are short-lived virgin cells
    • Chan EYT, MacLennan ICM. Only a small proportion of splenic B-cells in adults are short-lived virgin cells. Eur J Immunol. 23:1993;357-363.
    • (1993) Eur J Immunol , vol.23 , pp. 357-363
    • Chan, E.Y.T.1    MacLennan, I.C.M.2
  • 6
    • 0027420437 scopus 로고
    • + B cells, the major B cell subset in the peripheral blood, express V genes with no or little somatic mutation throughout life
    • + B cells, the major B cell subset in the peripheral blood, express V genes with no or little somatic mutation throughout life. Eur J Immunol. 23:1993;3272-3277.
    • (1993) Eur J Immunol , vol.23 , pp. 3272-3277
    • Klein, U.1    Kuppers, R.2    Rajewsky, K.3
  • 8
    • 0031456145 scopus 로고    scopus 로고
    • Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool
    • of outstanding interest. This reports that the Syk tyrosine kinase is associated with signalling via the CD79 molecules, which are linked to the surface immunoglobulin of B cells. Immature B cells are formed in these mice and migrate to the T-cell-rich zone of the spleen but fail to mature to become recirculating cells. This finding is compatible with the hypothesis that signalling through the B-cell receptor for antigen is required for immature B cells to become recirculating cells.
    • of outstanding interest Turner M, Gulbranson-Judge A, Quinn ME, Walters AE, MacLennan ICM, Tybulewicz VLJ. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool. J Exp Med. 186:1997;2012-2013 This reports that the Syk tyrosine kinase is associated with signalling via the CD79 molecules, which are linked to the surface immunoglobulin of B cells. Immature B cells are formed in these mice and migrate to the T-cell-rich zone of the spleen but fail to mature to become recirculating cells. This finding is compatible with the hypothesis that signalling through the B-cell receptor for antigen is required for immature B cells to become recirculating cells.
    • (1997) J Exp Med , vol.186 , pp. 2012-2013
    • Turner, M.1    Gulbranson-Judge, A.2    Quinn, M.E.3    Walters, A.E.4    MacLennan, I.C.M.5    Tybulewicz, V.L.J.6
  • 9
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • of outstanding interest. Experiments are reported in which the variable region of the immunoglobulin of a proportion of peripheral B cells is deleted in vivo. These cells die within a few days, implying that periodic signalling through the B-cell receptor for antigen is required for continued survival of recirculating, and perhaps other, peripheral B cells.
    • of outstanding interest Lam KP, Kühn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 90:1997;1073-1083 Experiments are reported in which the variable region of the immunoglobulin of a proportion of peripheral B cells is deleted in vivo. These cells die within a few days, implying that periodic signalling through the B-cell receptor for antigen is required for continued survival of recirculating, and perhaps other, peripheral B cells.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kühn, R.2    Rajewsky, K.3
  • 10
    • 0023892588 scopus 로고
    • Memory B cells in T-cell dependent antibody responses colonize the splenic marginal zones
    • Liu YJ, Oldfield S, MacLennan ICM. Memory B cells in T-cell dependent antibody responses colonize the splenic marginal zones. Eur J Immunol. 18:1988;355-362.
    • (1988) Eur J Immunol , vol.18 , pp. 355-362
    • Liu, Y.J.1    Oldfield, S.2    MacLennan, I.C.M.3
  • 11
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob J, Kassir R, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med. 173:1991;1165-1175.
    • (1991) J Exp Med , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 12
    • 0028064578 scopus 로고
    • Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
    • Cyster JG, Hartley SB, Goodnow CC. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 371:1994;389-395.
    • (1994) Nature , vol.371 , pp. 389-395
    • Cyster, J.G.1    Hartley, S.B.2    Goodnow, C.C.3
  • 13
    • 0029550111 scopus 로고
    • Antigen-induced exclusion from follicles and anergy are separate and complementary process that influence peripheral B cell fate
    • Cyster JG, Goodnow CC. Antigen-induced exclusion from follicles and anergy are separate and complementary process that influence peripheral B cell fate. Immunity. 3:1995;691-701.
    • (1995) Immunity , vol.3 , pp. 691-701
    • Cyster, J.G.1    Goodnow, C.C.2
  • 14
    • 0016156775 scopus 로고
    • Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labelling
    • Osmond DG, Nossal GJV. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labelling. Cell Immunol. 13:1974;132-145.
    • (1974) Cell Immunol , vol.13 , pp. 132-145
    • Osmond, D.G.1    Nossal, G.J.V.2
  • 15
    • 0023265029 scopus 로고
    • Newly-produced virgin B cells migrate to secondary lymphoid organs, but their capacity to enter follicles is restricted
    • Lortan JE, Roobottom CA, Oldfield S, MacLennan ICM. Newly-produced virgin B cells migrate to secondary lymphoid organs, but their capacity to enter follicles is restricted. Eur J Immunol. 17:1987;1311-1316.
    • (1987) Eur J Immunol , vol.17 , pp. 1311-1316
    • Lortan, J.E.1    Roobottom, C.A.2    Oldfield, S.3    MacLennan, I.C.M.4
  • 16
    • 0027379716 scopus 로고
    • Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
    • Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 151:1993;4431-4444.
    • (1993) J Immunol , vol.151 , pp. 4431-4444
    • Allman, D.M.1    Ferguson, S.E.2    Lentz, V.M.3    Cancro, M.P.4
  • 17
    • 0021012444 scopus 로고
    • Pre-B cells in mouse bone marrow: Immunofluorescence stathmokinetic studies of proliferation of cytoplasmic μ-chain-bearing cells in normal mice
    • Opstelten D, Osmond DG. Pre-B cells in mouse bone marrow: Immunofluorescence stathmokinetic studies of proliferation of cytoplasmic μ-chain-bearing cells in normal mice. J Immunol. 131:1983;2635-2640.
    • (1983) J Immunol , vol.131 , pp. 2635-2640
    • Opstelten, D.1    Osmond, D.G.2
  • 19
    • 0022907589 scopus 로고
    • Differences in recruitment of virgin B cells into antibody responses to thymus-dependent and thymus-independent type-2 antigens
    • Lane PJL, Gray D, MacLennan ICM. Differences in recruitment of virgin B cells into antibody responses to thymus-dependent and thymus-independent type-2 antigens. Eur J Immunol. 16:1986;1569-1575.
    • (1986) Eur J Immunol , vol.16 , pp. 1569-1575
    • Lane, P.J.L.1    Gray, D.2    MacLennan, I.C.M.3
  • 20
    • 0023951443 scopus 로고
    • Population kinetics of rat peripheral B cells
    • Gray D. Population kinetics of rat peripheral B cells. J Exp Med. 167:1988;805-816.
    • (1988) J Exp Med , vol.167 , pp. 805-816
    • Gray, D.1
  • 21
    • 0024444922 scopus 로고
    • Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse
    • Förster I, Vieira P, Rajewsky K. Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int Immunol. 1:1989;321-331.
    • (1989) Int Immunol , vol.1 , pp. 321-331
    • Förster, I.1    Vieira, P.2    Rajewsky, K.3
  • 22
    • 0031003643 scopus 로고    scopus 로고
    • Influences on life-span of B cell subpopulations defined by different phenotypes
    • of special interest. A useful study of the life span of immature and mature B cells in normal and Bcl-2-transgenic mice.
    • of special interest Fulcher DA, Basten A. Influences on life-span of B cell subpopulations defined by different phenotypes. Eur J Immunol. 27:1997;1188-1199 A useful study of the life span of immature and mature B cells in normal and Bcl-2-transgenic mice.
    • (1997) Eur J Immunol , vol.27 , pp. 1188-1199
    • Fulcher, D.A.1    Basten, A.2
  • 23
    • 0025902285 scopus 로고
    • Mature murine B and T cells transferred into SCID mice can survive indefinitely and many maintain a virgin phenotype
    • Sprent J, Schaefer M, Hurd M, Surh CD, Ron Y. Mature murine B and T cells transferred into SCID mice can survive indefinitely and many maintain a virgin phenotype. J Exp Med. 17:1991;717-728.
    • (1991) J Exp Med , vol.17 , pp. 717-728
    • Sprent, J.1    Schaefer, M.2    Hurd, M.3    Surh, C.D.4    Ron, Y.5
  • 24
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kühn R, Rajewsky K, Müller W. Generation and analysis of interleukin-4 deficient mice. Science. 254:1991;707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kühn, R.1    Rajewsky, K.2    Müller, W.3
  • 25
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature. 381:1996;751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 27
    • 0028176654 scopus 로고
    • Heavy-chain-directed B cell maturation: Continuous clonal selection beginning at the pre-B cell stage
    • Schwartz RS, Stollar DB. Heavy-chain-directed B cell maturation: continuous clonal selection beginning at the pre-B cell stage. Immunol Today. 15:1994;27-32.
    • (1994) Immunol Today , vol.15 , pp. 27-32
    • Schwartz, R.S.1    Stollar, D.B.2
  • 28
    • 0024529870 scopus 로고
    • Clonal deletion of auto-reactive B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee DA, Bürki K. Clonal deletion of auto-reactive B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:1989;562-566.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Bürki, K.2
  • 29
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognising membrane-bound antigen
    • Hartley SB, Crosbie J, Brink RA, Kantor AB, Basten A, Goodnow CC. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognising membrane-bound antigen. Nature. 353:1991;765-769.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.A.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 31
    • 0030827382 scopus 로고    scopus 로고
    • Regulation of anti-double-stranded DNA B cells in non-autoimmune mice: Localization to the T-B interface of the splenic follicle
    • of special interest. This paper follows the fate of B cells expressing a transgenic B-cell receptor for antigen with specificity for double-stranded DNA in mice with a nonautoimmune background. In these mice the B cells expressing the transgene make a priming response to endogenous antigen and accumulate in the outer T-cell-rich zone of the spleen. In the presence of normal B cells they fail to mature to become recirculating cells.
    • of special interest Mandik-Nayak L, Bui A, Noorchashm H, Eaton A, Erikson J. Regulation of anti-double-stranded DNA B cells in non-autoimmune mice: localization to the T-B interface of the splenic follicle. J Exp Med. 186:1997;1257-1267 This paper follows the fate of B cells expressing a transgenic B-cell receptor for antigen with specificity for double-stranded DNA in mice with a nonautoimmune background. In these mice the B cells expressing the transgene make a priming response to endogenous antigen and accumulate in the outer T-cell-rich zone of the spleen. In the presence of normal B cells they fail to mature to become recirculating cells.
    • (1997) J Exp Med , vol.186 , pp. 1257-1267
    • Mandik-Nayak, L.1    Bui, A.2    Noorchashm, H.3    Eaton, A.4    Erikson, J.5
  • 32
  • 33
    • 0000387536 scopus 로고
    • B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn
    • Law DA, Chan VWF, Datta SK, DeFranco AL. B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr Biol. 3:1993;645-657.
    • (1993) Curr Biol , vol.3 , pp. 645-657
    • Law, D.A.1    Chan, V.W.F.2    Datta, S.K.3    Defranco, A.L.4
  • 35
    • 0028783322 scopus 로고
    • Syk tyrosine kinase required for mouse viability and B-cell development
    • Cheng AM, Rowley B, Pao W, Hayday A, Bolen JA, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 378:1995;303-306.
    • (1995) Nature , vol.378 , pp. 303-306
    • Cheng, A.M.1    Rowley, B.2    Pao, W.3    Hayday, A.4    Bolen, J.A.5    Pawson, T.6
  • 36
    • 0030840550 scopus 로고    scopus 로고
    • Role of Btk in B cell development and signalling
    • Desiderio S. Role of Btk in B cell development and signalling. Curr Opin Immunol. 9:1997;534-540.
    • (1997) Curr Opin Immunol , vol.9 , pp. 534-540
    • Desiderio, S.1
  • 37
    • 0023258935 scopus 로고
    • Development of lymphocytes-B in mice heterozygous for the X-linked immunodeficiency (xid) mutation
    • Forrester LM, Ansell JD, Micklem HS. Development of lymphocytes-B in mice heterozygous for the X-linked immunodeficiency (xid) mutation. J Exp Med. 165:1987;949-958.
    • (1987) J Exp Med , vol.165 , pp. 949-958
    • Forrester, L.M.1    Ansell, J.D.2    Micklem, H.S.3
  • 38
    • 0020656815 scopus 로고
    • The ontogeny and distribution of B cells in normal and mutant immune defective CBA/N mice: Two parameter analysis of IgM and IgD
    • Scher I, Titus JA, Finkelman FD. The ontogeny and distribution of B cells in normal and mutant immune defective CBA/N mice: two parameter analysis of IgM and IgD. J Immunol. 130:1983;619-625.
    • (1983) J Immunol , vol.130 , pp. 619-625
    • Scher, I.1    Titus, J.A.2    Finkelman, F.D.3
  • 39
    • 0021060430 scopus 로고
    • Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence
    • Hardy RR, Hayakawa K, Parkes DR, Herzenberg LA. Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence. Nature. 306:1983;270-272.
    • (1983) Nature , vol.306 , pp. 270-272
    • Hardy, R.R.1    Hayakawa, K.2    Parkes, D.R.3    Herzenberg, L.A.4
  • 40
    • 0024238004 scopus 로고
    • CBA/N mice have marginal zone B cells with normal surface immunoglobulin phenotype
    • Liu YJ, Lortan JE, Oldfield S, MacLennan ICM. CBA/N mice have marginal zone B cells with normal surface immunoglobulin phenotype. Adv Exp Med Biol. 237:1988;105-111.
    • (1988) Adv Exp Med Biol , vol.237 , pp. 105-111
    • Liu, Y.J.1    Lortan, J.E.2    Oldfield, S.3    MacLennan, I.C.M.4
  • 41
    • 0020036442 scopus 로고
    • Lack of mature B cells in nude mice with X-linked immune deficiency
    • Wortis HH, Burkly L, Hughes D, Roschelle S, Waneck G. Lack of mature B cells in nude mice with X-linked immune deficiency. J Exp Med. 155:1982;903-913.
    • (1982) J Exp Med , vol.155 , pp. 903-913
    • Wortis, H.H.1    Burkly, L.2    Hughes, D.3    Roschelle, S.4    Waneck, G.5
  • 42
    • 0031041694 scopus 로고    scopus 로고
    • Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40
    • of outstanding interest. This paper assesses the effect of combined CD40 and Btk defect on B cell development and immune responses. This mimics to a considerable extent the profound B cell defect seen when the CBA/N (xid) mice carry the nude mouse mutation and are therefore athymic.
    • of outstanding interest Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int Immunol. 9:1997;395-405 This paper assesses the effect of combined CD40 and Btk defect on B cell development and immune responses. This mimics to a considerable extent the profound B cell defect seen when the CBA/N (xid) mice carry the nude mouse mutation and are therefore athymic.
    • (1997) Int Immunol , vol.9 , pp. 395-405
    • Khan, W.N.1    Nilsson, A.2    Mizoguchi, E.3    Castigli, E.4    Forsell, J.5    Bhan, A.K.6    Geha, R.7    Sideras, P.8    Alt, F.W.9
  • 43
    • 0023686940 scopus 로고
    • B-cell memory to thymus independent type 1 and type 2 antigens: The role of polysaccharide in B-memory induction
    • Zhang J, Liu YJ, MacLennan ICM, Gray D, Lane PJL. B-cell memory to thymus independent type 1 and type 2 antigens: the role of polysaccharide in B-memory induction. Eur J Immunol. 18:1988;1417-1424.
    • (1988) Eur J Immunol , vol.18 , pp. 1417-1424
    • Zhang, J.1    Liu, Y.J.2    MacLennan, I.C.M.3    Gray, D.4    Lane, P.J.L.5
  • 44
    • 0030023652 scopus 로고    scopus 로고
    • Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
    • of outstanding interest. The effect of CD45 deficiency on B cell development is described. Marked abnormalities are identified in these mice in the selection and priming responses discussed in this review.
    • of outstanding interest Cyster JG, Healy JL, Kishihara K, Mak TW, Thomas ML, Goodnow CC. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature. 381:1996;325-328 The effect of CD45 deficiency on B cell development is described. Marked abnormalities are identified in these mice in the selection and priming responses discussed in this review.
    • (1996) Nature , vol.381 , pp. 325-328
    • Cyster, J.G.1    Healy, J.L.2    Kishihara, K.3    Mak, T.W.4    Thomas, M.L.5    Goodnow, C.C.6
  • 45
    • 0030014518 scopus 로고    scopus 로고
    • Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse
    • of special interest. This paper describes an interesting gene defect in mice that is associated with failure of immature B cells to become recirculating cells.
    • of special interest Lenz VM, Cancro MP, Nashold FE, Hayes CE. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J Immunol. 157:1996;598-606 This paper describes an interesting gene defect in mice that is associated with failure of immature B cells to become recirculating cells.
    • (1996) J Immunol , vol.157 , pp. 598-606
    • Lenz, V.M.1    Cancro, M.P.2    Nashold, F.E.3    Hayes, C.E.4
  • 46
    • 0031004822 scopus 로고    scopus 로고
    • Signalling thresholds and intraclonal competition in preimmune B-cell selection
    • of outstanding interest. An excellent review of the work from Cyster and colleagues on B cell tolerance and the molecular basis of peripheral B cell selection. It includes otherwise unpublished data on tyrosine kinase SHP1 deficiency.
    • of outstanding interest Cyster JG. Signalling thresholds and intraclonal competition in preimmune B-cell selection. Immunol Rev. 156:1997;87-101 An excellent review of the work from Cyster and colleagues on B cell tolerance and the molecular basis of peripheral B cell selection. It includes otherwise unpublished data on tyrosine kinase SHP1 deficiency.
    • (1997) Immunol Rev , vol.156 , pp. 87-101
    • Cyster, J.G.1
  • 47
    • 0343307005 scopus 로고    scopus 로고
    • Deletion of SHIP or SHP1 reveals two distinct pathways for inhibitory signaling
    • Ono M, Okada H, Bolland S, Yanagi SY, Kurosaki T, Ravetch JV. Deletion of SHIP or SHP1 reveals two distinct pathways for inhibitory signaling. Cell. 90:1997;293-301.
    • (1997) Cell , vol.90 , pp. 293-301
    • Ono, M.1    Okada, H.2    Bolland, S.3    Yanagi, S.Y.4    Kurosaki, T.5    Ravetch, J.V.6
  • 48
    • 0028961264 scopus 로고
    • Protein tyrosine phosphatase IC negatively regulates antigen receptor signaling in B lymphocytes and determines the thresholds for negative selection
    • Cyster JG, Goodnow CC. Protein tyrosine phosphatase IC negatively regulates antigen receptor signaling in B lymphocytes and determines the thresholds for negative selection. Immunity. 2:1995;13-24.
    • (1995) Immunity , vol.2 , pp. 13-24
    • Cyster, J.G.1    Goodnow, C.C.2
  • 49
    • 0030499431 scopus 로고    scopus 로고
    • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
    • Sato S, Miller A, Inaoki M, Bock CB, Jansen PJ, Tang MLK, Tedder TF. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity. 5:1996;551-562.
    • (1996) Immunity , vol.5 , pp. 551-562
    • Sato, S.1    Miller, A.2    Inaoki, M.3    Bock, C.B.4    Jansen, P.J.5    Tang, M.L.K.6    Tedder, T.F.7
  • 50
    • 0030848576 scopus 로고    scopus 로고
    • Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naïve and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy
    • of outstanding interest. This paper studies doses of antigen that can induce priming responses and anergic responses. Anergic B cells are shown, by administering appropriate doses of antigen, to be capable of migrating to the outer T-cell-rich zone of the spleen. Evidence is provided that suggests that certain doses of antigen may induce anergy without loss of capacity to make a selection response, even when normal immature B cells are present.
    • of outstanding interest Cook MC, Basten A, Fazekas de St Groth B. Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naïve and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy. J Exp Med. 186:1997;631-644 This paper studies doses of antigen that can induce priming responses and anergic responses. Anergic B cells are shown, by administering appropriate doses of antigen, to be capable of migrating to the outer T-cell-rich zone of the spleen. Evidence is provided that suggests that certain doses of antigen may induce anergy without loss of capacity to make a selection response, even when normal immature B cells are present.
    • (1997) J Exp Med , vol.186 , pp. 631-644
    • Cook, M.C.1    Basten, A.2    Fazekas De St Groth, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.