Enhanced invasion of tax-expressing fibroblasts into the basement membrane is repressed by phosphorylated ascorbate with simultaneous decreases in intracellular oxidative stress and NF-κB activation

Antioxidants and Redox Signaling

Volumn 2, Issue 4, 2000, Pages 727-738

  Nagao, N ^a   Etoh, T ^a   Yamaoka, S ^b   Okamoto, T ^c   Miwa, N ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; TAX PROTEIN;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPHOSPHORYLATION; FIBROBLAST; GENE REPRESSION; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034536226     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2000.2.4-727     Document Type: Article

References (60)

1. Stromal cell oxidation: A mechanism by which tumors obtain vitamin C
2. A rapid in vitro assay for quantitating the invasive potential of tumor cells
3. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine
4. The phagokinetic tracks of 3T3 cells
5. Glutathione protects metastatic melanoma cells against oxidative stress in the murine hepatic microvasculature
6. Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine
7. Ras oncogene mediated induction of a 92 kDa metalloproteinase strong correlation with the malignant phenotype
8. Oxidative stress and nuclear factor-kappa B activation: A reassessment of the evidence in the light of recent discoveries
9. Molecular mechanism of tumorigenesis in mice transgenic for the human T-cell leukemia virus Tax gene
10. The host environment promotes the constitutive activation of nuclear factor-κB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
11. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
12. N-Acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: New target for antioxidant therapy?
13. Intracelullar oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1
14. Probes for live-cell function
15. Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter
16. Ascorbic acid in the prevention and treatment of cancer
17. Inhibition of NF-κB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1
18. Cellular and viral protein interactions regulating IκB alpha activity during human retrovirus infection
19. Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells
20. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet
21. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
22. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB
23. PKC-dependent modulation of IκB alpha-NF-κB pathway in low metastatic B16F1 murine melanoma cells and in highly metastatic BL6 cells
24. Is NF-κB the sensor of oxidative stress?
25. Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion
26. Human T-cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state
27. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways
28. Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein
29. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
30. Activation of nuclear factor-κB in human metastatic melanoma cells and the effect of oxidative stress
31. Expression of a provirus of human T-cell leukaemia virus type 1 by DNA transfection
32. Changes in paramagnetic species of blood plasma following a mega-vitamin C intake
33. Macrophage potentiation of invasive capacity of rat ascites hepatoma cells
34. Role of ascorbate in the activation of NF-κB by tumour necrosis factor-alpha in T-cells
35. 2)-induced NF-κB DNA binding activity and DNA damage in HepG2 cells
36. Effect of reactive oxygen intermediates on the in vitro invasive capacity of tumor cells and liver metastasis in mice
37. Multiple redox regulation in NF-κB transcription factor activation
38. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
39. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
40. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
41. Oxygen-derived free-radical scavengers prolong survival in gastric cancer
42. Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein
43. Glutathione homeostasis in response to exercise training and nutritional supplements
44. Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway
45. IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice: IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression
46. Matrix metalloproteinases-2 and -9 are expressed in human neuroblastoma: Contribution of stromal cells to their production and correlation with metastasis
47. Inhibition of NFκB activation by vitamin E derivatives
48. Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2
49. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro
50. Suppression of intracellular Cu-Zn SOD results in enhanced motility and metastasis of Meth A sarcoma cells
51. Persistent oxidative stress in cancer
52. HTLV-I Tax and cytokeratin: Tax-expressing cells show morphological changes in keratin-containing cytoskeletal networks
53. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
54. Ascorbic acid recycling in human neutrophils
55. HTLV-1-associated diseases
56. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages
57. The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein
58. Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein
59. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
60. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro